Napsod
Generic Name
Naproxen
Manufacturer
Eskayef Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| napsod 550 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Napsod 550 mg Tablet contains Naproxen, a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, inflammation, and fever. It is effective for conditions such as arthritis, menstrual cramps, muscle aches, and various inflammatory disorders.
Uses & Indications
Dosage
Adults
For mild to moderate pain, initial dose 550 mg, then 275 mg every 6-8 hours as needed, or 550 mg twice daily. Maximum daily dose is 1375 mg. For chronic conditions, 550-1100 mg daily in two divided doses.
Elderly
Lower doses may be required due to increased risk of adverse effects, especially gastrointestinal bleeding and renal impairment. Initiate at the lowest effective dose.
Renal_impairment
Use with caution; a dose reduction may be necessary. Not recommended in severe renal impairment (creatinine clearance < 30 mL/min).
How to Take
Take orally with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water.
Mechanism of Action
Naproxen inhibits prostaglandin synthesis by non-selectively inhibiting cyclooxygenase (COX-1 and COX-2) enzymes. Prostaglandins are mediators of inflammation, pain, and fever. By reducing prostaglandin levels, Naproxen effectively reduces these symptoms.
Pharmacokinetics
Onset
Pain relief usually starts within 1 hour, anti-inflammatory effects may take longer (days to weeks).
Excretion
Mainly excreted in the urine (approximately 95%) as unchanged drug, 6-O-desmethylnaproxen, and their conjugates. A small amount is excreted in feces.
Half life
Approximately 12-17 hours, allowing for twice-daily dosing.
Absorption
Rapidly and completely absorbed from the gastrointestinal tract. Peak plasma concentrations are achieved within 2-4 hours after oral administration.
Metabolism
Extensively metabolized in the liver to 6-O-desmethylnaproxen, primarily via CYP2C9 and CYP1A2, and then conjugated with glucuronic acid.
Side Effects
Contraindications
- Known hypersensitivity to Naproxen or other NSAIDs
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe heart failure
- Severe renal impairment
- Severe hepatic impairment
- Third trimester of pregnancy
- Coronary Artery Bypass Graft (CABG) surgery (peri-operative pain)
Drug Interactions
Digoxin
Increased plasma digoxin levels.
Lithium
Increased plasma lithium levels, leading to toxicity.
SSRIs/SNRIs
Increased risk of gastrointestinal bleeding.
Cyclosporine
Increased risk of nephrotoxicity.
Methotrexate
Increased plasma methotrexate levels, leading to toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
ACE Inhibitors / ARBs
Reduced antihypertensive effect, increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Diuretics (e.g., Furosemide, Thiazides)
Reduced diuretic and antihypertensive effects, increased risk of renal impairment.
Antiplatelet agents (e.g., Aspirin, Clopidogrel)
Increased risk of bleeding.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, heartburn, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Rare cases of acute renal failure, hypertension, respiratory depression, and coma. Management involves symptomatic and supportive care. Gastric lavage or activated charcoal may be considered if ingestion is recent.
Pregnancy & Lactation
Pregnancy Category C (first and second trimesters); Category D (third trimester). Use during pregnancy should be avoided unless the potential benefits outweigh the risks. Contraindicated in the third trimester due to potential premature closure of the ductus arteriosus. Not recommended during breastfeeding as Naproxen is excreted in breast milk.
Side Effects
Contraindications
- Known hypersensitivity to Naproxen or other NSAIDs
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe heart failure
- Severe renal impairment
- Severe hepatic impairment
- Third trimester of pregnancy
- Coronary Artery Bypass Graft (CABG) surgery (peri-operative pain)
Drug Interactions
Digoxin
Increased plasma digoxin levels.
Lithium
Increased plasma lithium levels, leading to toxicity.
SSRIs/SNRIs
Increased risk of gastrointestinal bleeding.
Cyclosporine
Increased risk of nephrotoxicity.
Methotrexate
Increased plasma methotrexate levels, leading to toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
ACE Inhibitors / ARBs
Reduced antihypertensive effect, increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Diuretics (e.g., Furosemide, Thiazides)
Reduced diuretic and antihypertensive effects, increased risk of renal impairment.
Antiplatelet agents (e.g., Aspirin, Clopidogrel)
Increased risk of bleeding.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, heartburn, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Rare cases of acute renal failure, hypertension, respiratory depression, and coma. Management involves symptomatic and supportive care. Gastric lavage or activated charcoal may be considered if ingestion is recent.
Pregnancy & Lactation
Pregnancy Category C (first and second trimesters); Category D (third trimester). Use during pregnancy should be avoided unless the potential benefits outweigh the risks. Contraindicated in the third trimester due to potential premature closure of the ductus arteriosus. Not recommended during breastfeeding as Naproxen is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years from manufacturing date.
Availability
Pharmacies nationwide in Bangladesh
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established Naproxen's efficacy and safety in various pain and inflammatory conditions, including rheumatoid arthritis, osteoarthritis, and acute pain. Ongoing research focuses on optimizing NSAID use and minimizing side effects.
Lab Monitoring
- Complete Blood Count (CBC) (periodically for long-term therapy)
- Liver function tests (LFTs) (periodically for long-term therapy)
- Renal function tests (e.g., Creatinine, BUN) (periodically, especially in patients with pre-existing renal impairment or risk factors)
- Fecal occult blood test (if GI symptoms develop)
Doctor Notes
- Emphasize the black box warnings regarding cardiovascular and gastrointestinal risks.
- Consider prescribing a proton pump inhibitor (PPI) concomitantly for patients at high risk of GI complications.
- Regularly monitor renal function, blood pressure, and CBC in patients on long-term therapy.
- Educate patients about signs of GI bleeding and cardiovascular events.
Patient Guidelines
- Do not exceed the recommended dose.
- Take with food or milk to reduce stomach upset.
- Avoid alcohol while taking this medicine.
- Report any signs of stomach bleeding (black stools, vomiting blood) immediately.
- Inform your doctor about all other medications you are taking, especially blood thinners or other NSAIDs.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
May cause dizziness or drowsiness. If affected, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain a healthy diet to support overall health.
- Stay hydrated.
- Regular exercise, if appropriate for your condition.
- Avoid smoking and excessive alcohol consumption, as these can increase GI risks.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Napsod Brand
Other medicines available under the same brand name
