Naspro
Generic Name
Naproxen
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| naspro 500 mg tablet | ৳ 9.03 | ৳ 90.30 |
Description
Overview of the medicine
Naspro (Naproxen) is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, inflammation, and fever. It is commonly prescribed for conditions like arthritis, muscle aches, dental pain, and menstrual cramps.
Uses & Indications
Dosage
Adults
For mild to moderate pain, dysmenorrhea, or acute tendinitis/bursitis: Initially 500 mg, then 250 mg every 6-8 hours as needed. Maximum initial daily dose is 1250 mg; subsequent daily dose not to exceed 1000 mg.
Elderly
Use the lowest effective dose for the shortest duration. Increased risk of adverse effects.
Renal_impairment
Use with caution; dose reduction may be necessary. Not recommended in severe renal impairment (creatinine clearance < 30 mL/min).
How to Take
Take Naspro 500 mg tablet orally, preferably with food or milk to reduce gastrointestinal upset. Swallow the tablet whole with a glass of water; do not crush, chew, or break it.
Mechanism of Action
Naproxen works by reversibly inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, which are involved in the synthesis of prostaglandins. Prostaglandins are mediators of pain, inflammation, and fever, so by reducing their production, Naproxen alleviates these symptoms.
Pharmacokinetics
Onset
Pain relief starts within 1 hour; peak plasma concentrations reached in 2-4 hours.
Excretion
Primarily eliminated via the urine (95%) as naproxen and its metabolites; a small amount is excreted in feces.
Half life
Approximately 12-17 hours, allowing for twice-daily dosing.
Absorption
Rapidly and completely absorbed from the gastrointestinal tract. Food may delay the rate of absorption but not the extent.
Metabolism
Extensively metabolized in the liver, primarily to 6-O-desmethylnaproxen, and then conjugated.
Side Effects
Contraindications
- Hypersensitivity to naproxen, aspirin, or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer disease
- Severe heart failure (NYHA Class III-IV)
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- History of aspirin-induced asthma, urticaria, or allergic-type reactions
Drug Interactions
Lithium
Increased plasma lithium levels, leading to potential toxicity.
Diuretics
Reduced diuretic and antihypertensive effects.
Methotrexate
Increased plasma methotrexate levels, leading to potential toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration and bleeding.
Cyclosporine, Tacrolimus
Increased risk of nephrotoxicity.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Selective Serotonin Reuptake Inhibitors (SSRIs)
Increased risk of gastrointestinal bleeding.
Antiplatelet agents (e.g., Aspirin, Clopidogrel)
Increased risk of bleeding.
ACE Inhibitors / Angiotensin Receptor Blockers (ARBs)
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store below 25°C in a cool, dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, heartburn, nausea, vomiting, epigastric pain, GI bleeding, and rarely, acute renal failure, hypertension, and respiratory depression. Management involves symptomatic and supportive care. Gastric lavage or activated charcoal may be considered within an hour of ingestion. Hemodialysis is not effective.
Pregnancy & Lactation
Pregnancy Category C in early pregnancy, D in third trimester. Avoid during the third trimester due to potential fetal harm (e.g., premature closure of ductus arteriosus). Use with caution in the first two trimesters only if potential benefits outweigh risks. Naproxen is excreted in breast milk; therefore, it is generally not recommended during lactation.
Side Effects
Contraindications
- Hypersensitivity to naproxen, aspirin, or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer disease
- Severe heart failure (NYHA Class III-IV)
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- History of aspirin-induced asthma, urticaria, or allergic-type reactions
Drug Interactions
Lithium
Increased plasma lithium levels, leading to potential toxicity.
Diuretics
Reduced diuretic and antihypertensive effects.
Methotrexate
Increased plasma methotrexate levels, leading to potential toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration and bleeding.
Cyclosporine, Tacrolimus
Increased risk of nephrotoxicity.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Selective Serotonin Reuptake Inhibitors (SSRIs)
Increased risk of gastrointestinal bleeding.
Antiplatelet agents (e.g., Aspirin, Clopidogrel)
Increased risk of bleeding.
ACE Inhibitors / Angiotensin Receptor Blockers (ARBs)
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store below 25°C in a cool, dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, heartburn, nausea, vomiting, epigastric pain, GI bleeding, and rarely, acute renal failure, hypertension, and respiratory depression. Management involves symptomatic and supportive care. Gastric lavage or activated charcoal may be considered within an hour of ingestion. Hemodialysis is not effective.
Pregnancy & Lactation
Pregnancy Category C in early pregnancy, D in third trimester. Avoid during the third trimester due to potential fetal harm (e.g., premature closure of ductus arteriosus). Use with caution in the first two trimesters only if potential benefits outweigh risks. Naproxen is excreted in breast milk; therefore, it is generally not recommended during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Available in pharmacies
Approval Status
Approved in Bangladesh
Patent Status
Generic available
Clinical Trials
Numerous clinical trials have established Naproxen's efficacy and safety in various pain and inflammatory conditions. Ongoing research focuses on its long-term cardiovascular and gastrointestinal safety profiles compared to other NSAIDs.
Lab Monitoring
- Complete Blood Count (CBC) periodically, especially with long-term therapy
- Renal function tests (serum creatinine, BUN) periodically
- Liver function tests (ALT, AST) periodically
- Blood pressure monitoring
Doctor Notes
- Assess patient's cardiovascular and gastrointestinal risk factors before prescribing Naproxen.
- Consider co-prescribing a proton pump inhibitor (PPI) for patients at high GI risk.
- Monitor blood pressure, renal function, and liver enzymes periodically during long-term therapy.
- Advise patients on symptoms of GI bleeding and cardiovascular events.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Take with food or milk to minimize stomach upset.
- Do not take more than the recommended dose or for longer than recommended.
- Report any signs of stomach bleeding (e.g., black, tarry stools, vomiting blood) to your doctor immediately.
- Avoid alcohol while taking this medicine.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness or drowsiness. Avoid driving or operating heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain a healthy diet and stay hydrated.
- Avoid smoking, as it increases the risk of GI bleeding with NSAIDs.
- Limit alcohol consumption.
- Regular exercise, if appropriate for your condition.
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Global Brand Names
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