Natazol
Generic Name
Naphazoline Hydrochloride
Manufacturer
Local Pharma Inc.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| natazol 0025 nasal drop | ৳ 40.00 | N/A |
Description
Overview of the medicine
Natazol 0.025% Nasal Drop contains Naphazoline Hydrochloride, a decongestant that helps to relieve nasal congestion and stuffiness by constricting blood vessels in the nose. It is commonly used for temporary relief of symptoms associated with colds, allergies, and sinusitis.
Uses & Indications
Dosage
Adults
1 to 2 drops in each nostril, not more often than every 4 to 6 hours, for a maximum of 3 to 5 days.
Elderly
Use with caution. Start with the lowest effective dose and frequency. Consult a doctor.
Renal_impairment
No specific dosage adjustment provided, use with caution due to potential for systemic absorption with prolonged use or overuse.
How to Take
Before use, gently blow your nose. Tilt your head back slightly and apply 1-2 drops into each nostril. Keep your head tilted for a few seconds. Avoid touching the dropper tip to your nose to prevent contamination. Do not use for more than 3-5 consecutive days to avoid rebound congestion.
Mechanism of Action
Naphazoline is an alpha-adrenergic agonist, primarily acting on alpha-1 receptors in the nasal mucosa. This causes vasoconstriction of the arterioles, leading to reduced blood flow, decreased swelling of the nasal membranes, and improved nasal airflow.
Pharmacokinetics
Onset
Within minutes after administration.
Excretion
Metabolites and unchanged drug, if absorbed, are primarily excreted via the kidneys.
Half life
Systemic half-life not well-established due to minimal absorption; duration of local action is 4-6 hours.
Absorption
Minimal systemic absorption from nasal mucosa when used as directed. Some absorption may occur, especially with overuse or in children.
Metabolism
Any systemically absorbed drug is likely metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to Naphazoline or any component of the formulation.
- Narrow-angle glaucoma.
- Patients receiving Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of stopping MAOIs.
Drug Interactions
Tricyclic Antidepressants
May potentiate the pressor effects of Naphazoline.
Monoamine Oxidase Inhibitors (MAOIs)
Concurrent use may lead to a hypertensive crisis. Avoid using Naphazoline if you are taking or have taken MAOIs within the last 14 days.
Storage
Store below 30°C in a dry place, away from direct sunlight. Do not freeze.
Overdose
Symptoms of overdose may include severe drowsiness, sweating, slow heartbeat, coma, and hypothermia, particularly in children. Systemic absorption can lead to central nervous system depression or excitation, and cardiovascular effects. Management is supportive, focusing on symptomatic treatment.
Pregnancy & Lactation
Use with caution during pregnancy and lactation. Consult your doctor before use. While systemic absorption is minimal, data on safety are limited.
Side Effects
Contraindications
- Hypersensitivity to Naphazoline or any component of the formulation.
- Narrow-angle glaucoma.
- Patients receiving Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of stopping MAOIs.
Drug Interactions
Tricyclic Antidepressants
May potentiate the pressor effects of Naphazoline.
Monoamine Oxidase Inhibitors (MAOIs)
Concurrent use may lead to a hypertensive crisis. Avoid using Naphazoline if you are taking or have taken MAOIs within the last 14 days.
Storage
Store below 30°C in a dry place, away from direct sunlight. Do not freeze.
Overdose
Symptoms of overdose may include severe drowsiness, sweating, slow heartbeat, coma, and hypothermia, particularly in children. Systemic absorption can lead to central nervous system depression or excitation, and cardiovascular effects. Management is supportive, focusing on symptomatic treatment.
Pregnancy & Lactation
Use with caution during pregnancy and lactation. Consult your doctor before use. While systemic absorption is minimal, data on safety are limited.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 to 3 years (unopened). Once opened, use within 28 days or as directed.
Availability
Pharmacies, drugstores
Approval Status
Approved for OTC use
Patent Status
Expired
Clinical Trials
As a long-established compound, extensive clinical trials for its initial approval were conducted decades ago. Newer trials primarily focus on bioequivalence for generic formulations.
Lab Monitoring
- No specific lab monitoring is routinely required for Natazol 0.025% Nasal Drop.
Doctor Notes
- Emphasize to patients the importance of short-term use (max 3-5 days) to avoid rhinitis medicamentosa.
- Caution patients with hypertension, cardiovascular disease, hyperthyroidism, or diabetes due to potential for systemic effects with overuse.
- Recommend alternative non-pharmacological methods for congestion relief if appropriate.
Patient Guidelines
- Do not use for more than 3-5 consecutive days to avoid rebound congestion (rhinitis medicamentosa).
- Consult a doctor if symptoms do not improve within 7 days or worsen.
- Avoid sharing nasal drops to prevent the spread of infection.
- Keep out of reach of children.
Missed Dose Advice
If you miss a dose, use it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Natazol 0.025% Nasal Drop is unlikely to affect your ability to drive or operate machinery. However, if systemic effects like dizziness or lightheadedness occur, caution is advised.
Lifestyle Advice
- Maintain good hydration to help thin nasal secretions.
- Avoid known allergens if allergies are the cause of congestion.
- Humidifiers can help moisten nasal passages.
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