Natazol
Generic Name
Fluticasone Propionate 0.05% Nasal Drop
Manufacturer
Reputable Pharmaceutical Co. Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| natazol 005 nasal drop | ৳ 45.00 | N/A |
Description
Overview of the medicine
Natazol 0.05% Nasal Drop is a corticosteroid medication used to treat symptoms of allergic rhinitis, such as sneezing, runny nose, itchy nose, and nasal congestion, by reducing inflammation in the nasal passages.
Uses & Indications
Dosage
Adults
Adults and adolescents 12 years and older: Initially, 2 sprays into each nostril once daily. May be reduced to 1 spray per nostril once daily for maintenance, or increased to 2 sprays twice daily if needed.
Elderly
No specific dose adjustment is required for elderly patients.
Renal_impairment
No dosage adjustment is required for patients with renal impairment.
How to Take
For nasal use only. Shake gently before use. Clear your nasal passages, then tilt your head slightly forward. Insert the nozzle into one nostril and press the pump while sniffing gently. Repeat for the other nostril. Avoid spraying into the eyes or directly onto the nasal septum.
Mechanism of Action
Fluticasone Propionate is a synthetic corticosteroid with potent anti-inflammatory effects. It works by reducing the inflammation in the nasal passages, thereby alleviating symptoms of allergic rhinitis.
Pharmacokinetics
Onset
Onset of action typically occurs within 12 hours, with full effect achieved after several days (3-4 days) of regular use.
Excretion
Excreted primarily in the feces, with a small portion excreted in urine.
Half life
Systemic half-life is approximately 3-5 hours.
Absorption
Minimal systemic absorption after nasal administration (bioavailability <2%). Peak plasma concentrations are generally low or undetectable.
Metabolism
Primarily metabolized in the liver via CYP3A4 into inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to fluticasone propionate or any component of the formulation
- Untreated localized infection involving the nasal mucosa (e.g., fungal, bacterial, or viral)
Drug Interactions
Ritonavir
Concurrent use may significantly increase fluticasone propionate systemic exposure, leading to potential corticosteroid systemic effects. Avoid co-administration unless the benefit outweighs the increased risk.
Ketoconazole
May increase systemic exposure to fluticasone propionate, but generally not clinically significant with typical nasal doses.
Storage
Store below 30°C in a dry place. Do not freeze. Keep out of reach of children. Keep the cap tightly closed when not in use.
Overdose
Acute overdose is unlikely due to the low systemic absorption. Chronic overdose may lead to signs of hypercorticism. Treatment is symptomatic and supportive, usually involving gradual reduction of the nasal spray.
Pregnancy & Lactation
Use in pregnancy only if the potential benefit outweighs the potential risk to the fetus. Small amounts may be excreted in breast milk; caution is advised during breastfeeding, and a physician should be consulted.
Side Effects
Contraindications
- Hypersensitivity to fluticasone propionate or any component of the formulation
- Untreated localized infection involving the nasal mucosa (e.g., fungal, bacterial, or viral)
Drug Interactions
Ritonavir
Concurrent use may significantly increase fluticasone propionate systemic exposure, leading to potential corticosteroid systemic effects. Avoid co-administration unless the benefit outweighs the increased risk.
Ketoconazole
May increase systemic exposure to fluticasone propionate, but generally not clinically significant with typical nasal doses.
Storage
Store below 30°C in a dry place. Do not freeze. Keep out of reach of children. Keep the cap tightly closed when not in use.
Overdose
Acute overdose is unlikely due to the low systemic absorption. Chronic overdose may lead to signs of hypercorticism. Treatment is symptomatic and supportive, usually involving gradual reduction of the nasal spray.
Pregnancy & Lactation
Use in pregnancy only if the potential benefit outweighs the potential risk to the fetus. Small amounts may be excreted in breast milk; caution is advised during breastfeeding, and a physician should be consulted.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date. Once opened, use within 3 months and discard any remaining solution.
Availability
Pharmacies nationwide
Approval Status
Approved by Regulatory Authorities
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have established the efficacy and safety of fluticasone propionate nasal spray for the treatment of seasonal and perennial allergic rhinitis, as well as for nasal polyps.
Lab Monitoring
- No routine lab monitoring is generally required for nasal fluticasone propionate.
- Growth monitoring in pediatric patients during long-term use.
- Intraocular pressure monitoring during long-term use (especially if risk factors for glaucoma exist).
Doctor Notes
- Counsel patients on proper nasal spray technique to ensure optimal drug delivery and minimize local irritation.
- Advise patients that full therapeutic effects may take several days, and consistent use is key.
- Monitor for signs of local infection, nasal septal integrity, and systemic corticosteroid effects (rarely) with prolonged use.
Patient Guidelines
- Use regularly as prescribed for best results, do not stop abruptly.
- Avoid contact with eyes; rinse thoroughly with water if contact occurs.
- Do not exceed the recommended dose.
- Seek medical advice if symptoms do not improve after 7 days or worsen.
- Proper nasal spray technique is crucial for efficacy.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
Natazol 0.05% Nasal Drop is not expected to affect the ability to drive or operate machinery, as it typically causes no systemic sedative effects.
Lifestyle Advice
- Identify and avoid known allergens in your environment.
- Keep windows closed during high pollen seasons.
- Consider using air purifiers at home.
- Regular nasal saline rinses can help clear irritants and maintain nasal hygiene.
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