Neforex
Generic Name
Omeprazole
Manufacturer
Popular Pharmaceuticals Ltd. (Example)
Country
Bangladesh (Example)
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| neforex 20 mg injection | ৳ 80.00 | N/A |
Description
Overview of the medicine
Neforex 20 mg Injection contains Omeprazole, a proton pump inhibitor used to reduce stomach acid production. It is used for the short-term treatment of certain conditions where oral medication is not possible, such as severe reflux esophagitis, Zollinger-Ellison syndrome, and prevention of stress ulcers.
Uses & Indications
Dosage
Adults
Typically 20 mg or 40 mg once daily via intravenous infusion over 20-30 minutes. For Zollinger-Ellison syndrome, initial dose is 60 mg once daily. Doses up to 120 mg/day may be given.
Elderly
No specific dose adjustment is usually required, but caution is advised due to potential age-related decrease in renal or hepatic function.
Renal_impairment
No dose adjustment necessary for patients with impaired renal function.
How to Take
Administered as an intravenous infusion over 20-30 minutes. Not to be given as a rapid bolus injection.
Mechanism of Action
Omeprazole works by irreversibly binding to and inhibiting the H+/K+-ATPase (proton pump) in the parietal cells of the stomach, thereby blocking the final step in gastric acid secretion. This leads to a dose-dependent inhibition of both basal and stimulated acid secretion.
Pharmacokinetics
Onset
Within 30 minutes for IV, peak effect within 2 hours.
Excretion
Approximately 80% excreted in urine as metabolites, and the remainder in feces.
Half life
Approximately 0.5-1 hour.
Absorption
Rapidly absorbed from the GI tract after oral administration; bioavailability is about 30-40% due to first-pass metabolism. For IV, bioavailability is 100%.
Metabolism
Extensively metabolized in the liver, primarily by CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to omeprazole or any components of the formulation, or to other substituted benzimidazoles (e.g., esomeprazole, lansoprazole).
- Concomitant use with nelfinavir.
Drug Interactions
Warfarin
Increased INR and prothrombin time may occur. Monitor closely.
Clopidogrel
Omeprazole may reduce the antiplatelet effect of clopidogrel. Concomitant use should be avoided unless absolutely necessary.
Nelfinavir, Atazanavir
Omeprazole decreases the plasma levels of these antiretrovirals, reducing their efficacy. Concomitant use is contraindicated for nelfinavir.
Diazepam, Phenytoin, Citalopram
Increased plasma concentrations of these drugs due to inhibition of CYP2C19 metabolism.
Storage
Store below 25°C in a dry place, protected from light. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and include nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs potential risk to the fetus. Small amounts excreted in breast milk; use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to omeprazole or any components of the formulation, or to other substituted benzimidazoles (e.g., esomeprazole, lansoprazole).
- Concomitant use with nelfinavir.
Drug Interactions
Warfarin
Increased INR and prothrombin time may occur. Monitor closely.
Clopidogrel
Omeprazole may reduce the antiplatelet effect of clopidogrel. Concomitant use should be avoided unless absolutely necessary.
Nelfinavir, Atazanavir
Omeprazole decreases the plasma levels of these antiretrovirals, reducing their efficacy. Concomitant use is contraindicated for nelfinavir.
Diazepam, Phenytoin, Citalopram
Increased plasma concentrations of these drugs due to inhibition of CYP2C19 metabolism.
Storage
Store below 25°C in a dry place, protected from light. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and include nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs potential risk to the fetus. Small amounts excreted in breast milk; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months for unopened vials. Reconstituted solution should be used within 12 hours (25°C) or 24 hours (2-8°C).
Availability
Hospitals, Clinics, Pharmacies
Approval Status
Approved by health authorities in various countries
Patent Status
Generic available (original patent expired)
WHO Essential Medicine
YesClinical Trials
Extensively studied for efficacy and safety in various acid-related disorders, demonstrating superior acid suppression compared to H2-receptor antagonists.
Lab Monitoring
- Liver function tests (in patients with severe hepatic impairment)
- INR/Prothrombin time (in patients on warfarin)
- Magnesium levels (for long-term use)
Doctor Notes
- Confirm diagnosis of acid-related disorder before initiating PPI therapy.
- Consider drug interactions, especially with clopidogrel and antiretrovirals.
- Monitor for potential long-term adverse effects if used for extended periods.
Patient Guidelines
- This medication is typically administered by a healthcare professional.
- Report any unusual symptoms or severe injection site reactions immediately.
- Inform your doctor about all medications you are taking, including over-the-counter drugs and supplements.
Missed Dose Advice
Since this is an injection typically given in a clinical setting, a healthcare professional will manage missed doses. If self-administering (unlikely for IV), contact your doctor for advice.
Driving Precautions
May cause dizziness or visual disturbances. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Avoid trigger foods and beverages that worsen acid reflux (e.g., spicy foods, caffeine, alcohol).
- Maintain a healthy weight.
- Avoid lying down immediately after meals.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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