Neforex
Generic Name
Fexofenadine Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| neforex 30 mg tablet | ৳ 3.00 | ৳ 30.00 |
Description
Overview of the medicine
Neforex 30 mg Tablet contains Fexofenadine Hydrochloride, a non-sedating antihistamine used to relieve symptoms of seasonal allergic rhinitis and chronic idiopathic urticaria. It helps to alleviate sneezing, runny nose, itchy eyes, watery eyes, and hives.
Uses & Indications
Dosage
Adults
For seasonal allergic rhinitis: 60 mg twice daily or 120-180 mg once daily. For chronic idiopathic urticaria: 180 mg once daily.
Elderly
No specific dosage adjustment is generally needed unless renal impairment is present.
Renal_impairment
For adults with impaired renal function (creatinine clearance ≤ 80 mL/min), the recommended initial dose is 60 mg once daily. For children with renal impairment, 30 mg once daily.
Children_6_11_years
For seasonal allergic rhinitis: 30 mg twice daily.
How to Take
Take orally, with or without food. Do not take with fruit juice (e.g., grapefruit, orange, apple) as it may reduce the absorption and effectiveness of fexofenadine.
Mechanism of Action
Fexofenadine selectively antagonizes peripheral H1-histamine receptors, thereby inhibiting the effects of histamine and reducing allergic symptoms. It does not readily cross the blood-brain barrier, resulting in minimal central nervous system effects like sedation.
Pharmacokinetics
Onset
Antihistaminic effect observed within 1 hour, maximum effect within 2-3 hours.
Excretion
Approximately 80% is excreted unchanged in feces and 11% in urine.
Half life
Elimination half-life is approximately 11-15 hours.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations reached in approximately 1-3 hours.
Metabolism
Minimally metabolized; approximately 5% of the total dose is metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to fexofenadine hydrochloride or any of its excipients.
Drug Interactions
Erythromycin and Ketoconazole
These drugs may increase plasma concentrations of fexofenadine, but this is generally not associated with increased adverse effects.
Antacids (aluminum and magnesium-containing)
Concurrent administration may decrease the absorption of fexofenadine. Separate administration by at least 2 hours.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, dizziness, and dry mouth. Management is symptomatic and supportive. Hemodialysis does not effectively remove fexofenadine from blood.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Fexofenadine is excreted in breast milk; use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to fexofenadine hydrochloride or any of its excipients.
Drug Interactions
Erythromycin and Ketoconazole
These drugs may increase plasma concentrations of fexofenadine, but this is generally not associated with increased adverse effects.
Antacids (aluminum and magnesium-containing)
Concurrent administration may decrease the absorption of fexofenadine. Separate administration by at least 2 hours.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, dizziness, and dry mouth. Management is symptomatic and supportive. Hemodialysis does not effectively remove fexofenadine from blood.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Fexofenadine is excreted in breast milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the date of manufacture, specific expiry date mentioned on packaging.
Availability
Available in pharmacies and hospitals nationwide
Approval Status
Approved by DGDA
Patent Status
Patent expired, generic available
WHO Essential Medicine
YesClinical Trials
Fexofenadine has undergone extensive clinical trials demonstrating its efficacy and safety for the treatment of seasonal allergic rhinitis and chronic idiopathic urticaria across various patient populations, including children and adults.
Lab Monitoring
- Routine laboratory monitoring is generally not required during fexofenadine therapy.
Doctor Notes
- Advise patients to avoid concurrent administration with fruit juices and aluminum/magnesium-containing antacids to prevent reduced bioavailability.
- Consider dose adjustment in patients with impaired renal function.
- Neforex 30mg is primarily indicated for children aged 6-11 years for allergic rhinitis symptoms.
Patient Guidelines
- Do not take with fruit juices.
- Inform your doctor about all other medications you are taking.
- Do not exceed the recommended dose.
- If symptoms persist or worsen, consult your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
Fexofenadine is generally non-drowsy. However, individuals should assess their response to the medication before driving or operating machinery, as rare cases of dizziness or fatigue have been reported.
Lifestyle Advice
- Avoid known allergens to reduce the frequency and severity of allergic reactions.
- Maintain good hydration.
- Consider using an air purifier at home.
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