Nefoxen
Generic Name
Nefoxen
Manufacturer
MediCorp Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nefoxen 120 mg tablet | ৳ 7.00 | ৳ 70.00 |
Description
Overview of the medicine
Nefoxen 120 mg tablet is a non-steroidal anti-inflammatory drug (NSAID) used for the relief of pain, inflammation, and fever.
Uses & Indications
Dosage
Adults
The usual adult dose is 120 mg once or twice daily, as directed by a physician. Do not exceed 240 mg in 24 hours.
Elderly
Lower initial doses may be required, and patients should be carefully monitored for renal and gastrointestinal adverse effects. Dose adjustments based on renal function are recommended.
Renal_impairment
Use with caution. Dose reduction may be necessary in patients with mild to moderate renal impairment. Avoid use in severe renal impairment.
How to Take
Nefoxen 120 mg tablets should be taken orally, preferably with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water, do not chew or crush.
Mechanism of Action
Nefoxen works by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, leading to reduced synthesis of prostaglandins, which are mediators of pain, inflammation, and fever.
Pharmacokinetics
Onset
Analgesic effects typically begin within 30-60 minutes.
Excretion
Mainly excreted in the urine (approximately 60-70% as metabolites), with some excretion in the faeces.
Half life
The elimination half-life is approximately 6-8 hours.
Absorption
Rapidly absorbed from the gastrointestinal (GI) tract following oral administration. Peak plasma concentrations are typically reached within 1-2 hours.
Metabolism
Primarily metabolized in the liver via cytochrome P450 (CYP) enzymes, forming inactive metabolites.
Side Effects
Contraindications
- Known hypersensitivity to Nefoxen, aspirin, or other NSAIDs
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Heart failure (NYHA Class II-IV)
- Third trimester of pregnancy
- Peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery
Drug Interactions
Lithium
Nefoxen can increase lithium plasma levels, leading to toxicity. Monitor lithium levels closely.
Methotrexate
Increased methotrexate toxicity. Administer with caution.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Cyclosporine, Tacrolimus
Increased risk of nephrotoxicity.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding. Close monitoring of INR is recommended.
Diuretics (e.g., Furosemide, Thiazides)
Reduced diuretic and antihypertensive effects, potential for renal impairment.
Antiplatelet agents (e.g., Aspirin, Clopidogrel)
Increased risk of gastrointestinal bleeding.
ACE inhibitors and Angiotensin II Receptor Blockers (ARBs)
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of Nefoxen overdose may include drowsiness, lethargy, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. In rare cases, hypertension, acute renal failure, respiratory depression, and coma may occur. Management involves supportive and symptomatic treatment. Gastric lavage and activated charcoal may be considered if ingested within a short time frame. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C (first and second trimesters); avoid in third trimester (Category D) due to potential for premature closure of the fetal ductus arteriosus and other adverse effects on the fetus. Excreted in breast milk; use with caution during lactation, only if potential benefit justifies the potential risk to the infant.
Side Effects
Contraindications
- Known hypersensitivity to Nefoxen, aspirin, or other NSAIDs
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Heart failure (NYHA Class II-IV)
- Third trimester of pregnancy
- Peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery
Drug Interactions
Lithium
Nefoxen can increase lithium plasma levels, leading to toxicity. Monitor lithium levels closely.
Methotrexate
Increased methotrexate toxicity. Administer with caution.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Cyclosporine, Tacrolimus
Increased risk of nephrotoxicity.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding. Close monitoring of INR is recommended.
Diuretics (e.g., Furosemide, Thiazides)
Reduced diuretic and antihypertensive effects, potential for renal impairment.
Antiplatelet agents (e.g., Aspirin, Clopidogrel)
Increased risk of gastrointestinal bleeding.
ACE inhibitors and Angiotensin II Receptor Blockers (ARBs)
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of Nefoxen overdose may include drowsiness, lethargy, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. In rare cases, hypertension, acute renal failure, respiratory depression, and coma may occur. Management involves supportive and symptomatic treatment. Gastric lavage and activated charcoal may be considered if ingested within a short time frame. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C (first and second trimesters); avoid in third trimester (Category D) due to potential for premature closure of the fetal ductus arteriosus and other adverse effects on the fetus. Excreted in breast milk; use with caution during lactation, only if potential benefit justifies the potential risk to the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture when stored under recommended conditions.
Availability
Pharmacies, Hospitals
Approval Status
Approved by health authorities
Patent Status
Patent pending
Clinical Trials
Clinical trials for Nefoxen have demonstrated its efficacy and safety profile in various pain and inflammatory conditions. Ongoing trials may explore extended indications or long-term safety data.
Lab Monitoring
- Complete Blood Count (CBC) for signs of anemia or bleeding (especially with long-term use).
- Renal function tests (serum creatinine, blood urea nitrogen - BUN) to monitor kidney health.
- Liver function tests (ALT, AST) to monitor liver health.
- Blood pressure monitoring.
Doctor Notes
- Prescribe the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
- Monitor patients for signs of gastrointestinal bleeding or cardiovascular adverse events, particularly in elderly patients or those with pre-existing conditions.
- Assess renal and hepatic function periodically, especially during long-term therapy.
Patient Guidelines
- Take Nefoxen exactly as prescribed by your doctor.
- Do not exceed the recommended dose or duration of treatment.
- Report any unusual or severe side effects, especially stomach pain, black stools, or unusual bleeding.
- Avoid concurrent use with other NSAIDs or aspirin without consulting your doctor.
Missed Dose Advice
If you miss a dose of Nefoxen, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Nefoxen may cause dizziness, drowsiness, or visual disturbances in some individuals. If you experience these effects, avoid driving or operating heavy machinery.
Lifestyle Advice
- Avoid or limit alcohol consumption to reduce the risk of gastrointestinal bleeding.
- Maintain adequate hydration by drinking plenty of fluids.
- Inform your healthcare provider about all medications, supplements, and herbal products you are taking.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Nefoxen Brand
Other medicines available under the same brand name
