Nefoxen
Generic Name
Fexofenadine Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nefoxen 180 mg tablet | ৳ 9.00 | ৳ 90.00 |
Description
Overview of the medicine
Fexofenadine is a second-generation antihistamine used to relieve allergy symptoms such as sneezing, runny nose, itchy nose/palate/throat, and itchy/watery eyes, as well as symptoms of chronic idiopathic urticaria like itching and hives.
Uses & Indications
Dosage
Adults
For Seasonal Allergic Rhinitis: 180 mg once daily or 60 mg twice daily. For Chronic Idiopathic Urticaria: 180 mg once daily.
Elderly
No specific dose adjustment generally required, but consider renal function.
Renal_impairment
Initial dose 60 mg once daily for moderate to severe renal impairment. Consult a doctor.
How to Take
Take orally with water, preferably before a meal. Do not take with fruit juice (e.g., grapefruit, orange, apple) as it may reduce absorption.
Mechanism of Action
Fexofenadine selectively inhibits peripheral H1-receptors, preventing histamine from binding and causing allergic reactions. It does not readily cross the blood-brain barrier, resulting in minimal sedative effects.
Pharmacokinetics
Onset
Within 1 hour.
Excretion
Primarily excreted unchanged in the feces (approx. 80%) and urine (approx. 10%).
Half life
Approximately 11-15 hours.
Absorption
Rapidly absorbed after oral administration; peak plasma concentrations reached in 1-3 hours.
Metabolism
Minimally metabolized in the liver (approx. 5% by CYP450 system).
Side Effects
Contraindications
- Hypersensitivity to fexofenadine hydrochloride or any of its excipients.
Drug Interactions
Erythromycin or Ketoconazole
May increase plasma concentrations of fexofenadine. Use with caution.
Antacids containing aluminum or magnesium
May decrease fexofenadine absorption; separate administration by 2 hours.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include dizziness, drowsiness, and dry mouth. Management is symptomatic and supportive; hemodialysis does not effectively remove fexofenadine from the blood.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Not recommended during breastfeeding as it is excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to fexofenadine hydrochloride or any of its excipients.
Drug Interactions
Erythromycin or Ketoconazole
May increase plasma concentrations of fexofenadine. Use with caution.
Antacids containing aluminum or magnesium
May decrease fexofenadine absorption; separate administration by 2 hours.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include dizziness, drowsiness, and dry mouth. Management is symptomatic and supportive; hemodialysis does not effectively remove fexofenadine from the blood.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Not recommended during breastfeeding as it is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture when stored under recommended conditions.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Fexofenadine has been extensively studied in numerous clinical trials demonstrating its efficacy and safety in treating seasonal allergic rhinitis and chronic idiopathic urticaria, showing comparable efficacy to other antihistamines with a favorable safety profile.
Lab Monitoring
- No routine lab monitoring required for fexofenadine.
Doctor Notes
- Emphasize to patients the importance of avoiding fruit juices around the time of administration to prevent reduced efficacy.
- Reassure patients about its non-sedating nature compared to older antihistamines, which may improve adherence.
- Advise patients to seek medical attention if symptoms persist or worsen despite treatment.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid taking this medicine with fruit juices.
- Inform your doctor or pharmacist about all other medications, including herbal supplements, you are currently taking.
- If symptoms do not improve or worsen, consult your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Although fexofenadine is generally non-sedating, some individuals may experience drowsiness or dizziness. Caution is advised when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Identify and avoid known allergens to reduce the frequency and severity of symptoms.
- Maintain good hydration and a healthy lifestyle.
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