Take orally with a glass of water, preferably with or after food, to minimize gastrointestinal upset. Do not crush, chew, or break the tablet; swallow it whole.

Diclofenac works by inhibiting the cyclooxygenase (COX) enzymes, COX-1 and COX-2, which are responsible for the synthesis of prostaglandins. Prostaglandins are mediators of pain, inflammation, and fever.

• •Hypersensitivity to diclofenac or other NSAIDs
• •Active gastrointestinal bleeding or peptic ulcer
• •Severe renal or hepatic failure
• •Severe heart failure
• •Third trimester of pregnancy
• •Coronary artery bypass graft (CABG) surgery

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Symptoms may include lethargy, drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. In rare cases, hypertension, acute renal failure, respiratory depression, and coma may occur. Management is primarily symptomatic and supportive; there is no specific antidote.

Avoid in the third trimester of pregnancy due to risk of premature closure of the ductus arteriosus. Use with caution during early pregnancy and lactation only if clearly needed and benefits outweigh risks. Consult a doctor.