Neofix
Generic Name
Cefixime
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| neofix 100 mg suspension | ৳ 180.00 | N/A |
Description
Overview of the medicine
Neofix 100 mg Suspension contains Cefixime, a third-generation cephalosporin antibiotic used to treat a wide range of bacterial infections. It is effective against various Gram-positive and Gram-negative bacteria.
Uses & Indications
Dosage
Adults
This 100 mg/5 ml suspension is primarily formulated for pediatric use. For adult Cefixime, typical dose is 200-400 mg daily (as single or two divided doses), usually in tablet/capsule form. For children (6 months to 12 years): 8 mg/kg/day, given as a single daily dose or in two divided doses. For Neofix 100 mg/5ml Suspension: 6 months-1 year: 3.75 ml once daily; 1-4 years: 5 ml once daily; 5-8 years: 10 ml once daily; 9-12 years: 15 ml once daily. Or as directed by physician.
Elderly
No specific dosage adjustment is required for elderly patients based on age alone, but renal function should be assessed and dose adjusted accordingly. Consult physician.
Renal_impairment
For creatinine clearance 21-60 mL/min, 75% of the standard daily dose. For creatinine clearance < 20 mL/min, 50% of the standard daily dose. Consult physician.
How to Take
Administer orally. Shake the bottle well before each use. Can be taken with or without food.
Mechanism of Action
Cefixime is a bactericidal antibiotic that acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which prevents the cross-linking of peptidoglycan chains, leading to cell lysis and bacterial death.
Pharmacokinetics
Onset
Peak plasma concentrations usually reached within 2-6 hours.
Excretion
Primarily excreted by the kidneys (50-60% as unchanged drug) and also via biliary excretion.
Half life
Approximately 3-4 hours.
Absorption
Approximately 40-50% orally absorbed. Food may delay absorption but does not significantly affect the extent.
Metabolism
Minimal hepatic metabolism.
Side Effects
Contraindications
- Hypersensitivity to Cefixime, other cephalosporins, or penicillins.
- Patients with a history of severe allergic reactions to any beta-lactam antibiotic.
Drug Interactions
Warfarin
May increase prothrombin time (PT) and INR, increasing risk of bleeding. Close monitoring required.
Carbamazepine
Increased carbamazepine levels reported with concomitant use. Monitor carbamazepine levels.
Oral Contraceptives
May decrease the efficacy of oral contraceptives. Advise patients to use an alternative or additional method of contraception.
Storage
Store dry powder below 30°C, protected from light and moisture. Keep reconstituted suspension in a refrigerator (2-8°C) and discard after 7 days.
Overdose
In case of overdose, gastric lavage may be indicated. There is no specific antidote. Treatment should be symptomatic and supportive. Hemodialysis or peritoneal dialysis does not remove significant quantities of cefixime.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. However, use during pregnancy should only be if clearly needed. Excreted in small amounts in breast milk; use with caution during lactation. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to Cefixime, other cephalosporins, or penicillins.
- Patients with a history of severe allergic reactions to any beta-lactam antibiotic.
Drug Interactions
Warfarin
May increase prothrombin time (PT) and INR, increasing risk of bleeding. Close monitoring required.
Carbamazepine
Increased carbamazepine levels reported with concomitant use. Monitor carbamazepine levels.
Oral Contraceptives
May decrease the efficacy of oral contraceptives. Advise patients to use an alternative or additional method of contraception.
Storage
Store dry powder below 30°C, protected from light and moisture. Keep reconstituted suspension in a refrigerator (2-8°C) and discard after 7 days.
Overdose
In case of overdose, gastric lavage may be indicated. There is no specific antidote. Treatment should be symptomatic and supportive. Hemodialysis or peritoneal dialysis does not remove significant quantities of cefixime.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. However, use during pregnancy should only be if clearly needed. Excreted in small amounts in breast milk; use with caution during lactation. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years for dry powder. Reconstituted suspension is stable for 7 days when stored in a refrigerator (2-8°C).
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available (patent expired)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of Cefixime for various bacterial infections. Ongoing post-marketing surveillance continues to monitor its long-term effects and safety profile.
Lab Monitoring
- Renal function tests (e.g., serum creatinine, BUN) in patients with pre-existing renal impairment or during prolonged therapy.
- Complete blood count (CBC) in patients on prolonged therapy.
Doctor Notes
- Assess patient history for hypersensitivity reactions to cephalosporins or penicillins.
- Consider renal function for dose adjustment, especially in pediatric and elderly patients.
- Counsel patients on completing the full course to prevent resistance.
Patient Guidelines
- Complete the full course of treatment as prescribed by your doctor, even if your symptoms improve.
- Do not stop taking the medicine early, as this may lead to recurrent infection and antibiotic resistance.
- Shake the suspension well before each use.
- Measure the dose accurately using the provided measuring device.
- Store the medicine as directed.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Driving Precautions
Cefixime generally does not impair the ability to drive or operate machinery. However, if you experience dizziness, avoid these activities until you feel well.
Lifestyle Advice
- Maintain good hygiene to prevent further infections.
- Drink plenty of fluids unless otherwise advised by your doctor.
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