neofix
Generic Name
Cefixime
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| neofix 200 mg capsule | ৳ 35.00 | N/A |
Description
Overview of the medicine
Neofix 200 mg Capsule contains Cefixime, a broad-spectrum third-generation cephalosporin antibiotic used to treat various bacterial infections.
Uses & Indications
Dosage
Adults
Adults: 200 mg once daily or 100 mg twice daily. Dosage may be increased to 400 mg once daily or 200 mg twice daily for severe infections. For uncomplicated gonorrhea, a single oral dose of 400 mg.
Elderly
Elderly patients: Dosage similar to adults, but renal function should be assessed and dose adjusted if necessary, especially in those with severe renal impairment.
Renal_impairment
For creatinine clearance 21-60 mL/min: 300 mg daily. For creatinine clearance < 20 mL/min: 200 mg daily.
How to Take
Neofix 200 mg capsule should be taken orally, with or without food. It is important to complete the full course of treatment as prescribed by the doctor.
Mechanism of Action
Cefixime acts by inhibiting bacterial cell wall synthesis, leading to bactericidal action. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which prevents the final transpeptidation step of peptidoglycan synthesis.
Pharmacokinetics
Onset
Peak plasma concentrations reached within 2-6 hours after oral administration.
Excretion
Excreted primarily by renal elimination (about 50% of an absorbed dose is excreted unchanged in urine within 24 hours).
Half life
Plasma elimination half-life is typically 3-4 hours.
Absorption
Approximately 40-50% orally absorbed. Food does not significantly alter absorption.
Metabolism
Not extensively metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to Cefixime or any other cephalosporin antibiotics.
- History of severe hypersensitivity reactions to penicillin or other beta-lactam antibiotics.
Drug Interactions
Warfarin
May increase prothrombin time with or without bleeding. Close monitoring of INR is recommended.
Carbamazepine
Elevated carbamazepine levels have been reported when co-administered with cefixime.
Oral Contraceptives
May reduce the efficacy of oral contraceptives; additional contraceptive methods may be needed.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Supportive treatment is recommended.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. However, adequate and well-controlled studies in pregnant women are lacking. Use during pregnancy only if clearly needed. Cefixime is excreted in small amounts in human breast milk; use with caution in breastfeeding mothers.
Side Effects
Contraindications
- Hypersensitivity to Cefixime or any other cephalosporin antibiotics.
- History of severe hypersensitivity reactions to penicillin or other beta-lactam antibiotics.
Drug Interactions
Warfarin
May increase prothrombin time with or without bleeding. Close monitoring of INR is recommended.
Carbamazepine
Elevated carbamazepine levels have been reported when co-administered with cefixime.
Oral Contraceptives
May reduce the efficacy of oral contraceptives; additional contraceptive methods may be needed.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Supportive treatment is recommended.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. However, adequate and well-controlled studies in pregnant women are lacking. Use during pregnancy only if clearly needed. Cefixime is excreted in small amounts in human breast milk; use with caution in breastfeeding mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture, check package for exact expiry date.
Availability
Available in pharmacies and hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Cefixime has undergone numerous clinical trials demonstrating its efficacy and safety for various bacterial infections since its approval. Ongoing post-marketing surveillance and studies continue.
Lab Monitoring
- Periodic assessment of renal function is advisable during prolonged therapy, especially in patients with pre-existing renal impairment.
- Blood counts (CBC) may be monitored in patients receiving prolonged treatment.
Doctor Notes
- Emphasize patient adherence to the full prescribed course to minimize resistance.
- Be alert for signs of superinfection, especially C. difficile diarrhea.
- Adjust dosage for renal impairment, especially in elderly patients.
Patient Guidelines
- Take the medicine for the entire duration prescribed by your doctor, even if your symptoms improve.
- Do not skip doses or stop treatment early, as this may lead to antibiotic resistance.
- Do not share this medicine with others, even if they have similar symptoms.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
This medicine may cause dizziness or lightheadedness in some individuals. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Maintain good personal hygiene to prevent infections.
- Stay hydrated by drinking plenty of fluids, especially if experiencing diarrhea.
- Eat a balanced diet to support your immune system.
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