Neopem
Generic Name
Neopenem
Manufacturer
Meditopix Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| neopem 150 mg tablet | ৳ 75.00 | ৳ 300.00 |
Description
Overview of the medicine
Neopem is a broad-spectrum carbapenem antibiotic used to treat various bacterial infections. It is effective against a wide range of gram-positive and gram-negative bacteria.
Uses & Indications
Dosage
Adults
150 mg orally every 12 hours for 7-14 days, depending on infection severity and type.
Elderly
No specific dose adjustment for elderly patients with normal renal function. Monitor renal function.
Renal_impairment
Dose adjustment required. For CrCl 30-49 mL/min: 75 mg every 12 hours. For CrCl <30 mL/min: 75 mg every 24 hours.
How to Take
Take Neopem-150-mg-tablet orally with a full glass of water, with or without food. It is important to complete the full course of treatment as prescribed by your doctor.
Mechanism of Action
Neopenem inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis and death. It is highly stable to hydrolysis by most beta-lactamases, including extended-spectrum beta-lactamases (ESBLs).
Pharmacokinetics
Onset
Rapid, typically within 1 hour.
Excretion
Primarily renal, with approximately 70% excreted unchanged in urine within 12 hours.
Half life
Approximately 1.5 to 2 hours.
Absorption
Well absorbed orally; peak plasma concentrations achieved within 1-2 hours.
Metabolism
Minimally metabolized; primarily hydrolyzed in the kidney by dehydropeptidase-I, leading to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Neopenem or any other carbapenem antibiotics.
- Severe hypersensitivity reactions to any other beta-lactam antibiotics (e.g., penicillins, cephalosporins).
- Known history of severe renal impairment without dose adjustment.
Drug Interactions
Probenecid
Increases plasma concentrations and half-life of Neopenem, prolonging its effect. Concomitant use should be monitored.
Valproic acid
May decrease valproic acid plasma concentrations, increasing the risk of seizures. Co-administration is generally not recommended.
Storage
Store below 30°C in a dry place. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, supportive care and symptomatic treatment should be initiated. Hemodialysis may be useful for removing Neopenem from the system in severe cases.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed and the potential benefits outweigh the potential risks to the fetus. Small amounts may be excreted in breast milk; consult your doctor before breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to Neopenem or any other carbapenem antibiotics.
- Severe hypersensitivity reactions to any other beta-lactam antibiotics (e.g., penicillins, cephalosporins).
- Known history of severe renal impairment without dose adjustment.
Drug Interactions
Probenecid
Increases plasma concentrations and half-life of Neopenem, prolonging its effect. Concomitant use should be monitored.
Valproic acid
May decrease valproic acid plasma concentrations, increasing the risk of seizures. Co-administration is generally not recommended.
Storage
Store below 30°C in a dry place. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, supportive care and symptomatic treatment should be initiated. Hemodialysis may be useful for removing Neopenem from the system in severe cases.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed and the potential benefits outweigh the potential risks to the fetus. Small amounts may be excreted in breast milk; consult your doctor before breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved (Hypothetical)
Patent Status
Patent pending
Clinical Trials
Currently undergoing Phase III clinical trials for broader indications.
Lab Monitoring
- Renal function tests (e.g., creatinine, BUN) periodically, especially in patients with pre-existing renal impairment.
- Liver function tests (e.g., ALT, AST) if treatment is prolonged or in patients with liver disease.
- Complete blood count (CBC) during prolonged therapy.
Doctor Notes
- Monitor renal function closely, especially in elderly and renally impaired patients.
- Counsel patients on potential central nervous system side effects like seizures, especially if there's a history of epilepsy.
- Emphasize completion of the full antibiotic course.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking the medicine early, even if you feel better.
- Inform your doctor about any unusual side effects or allergic reactions.
- Stay hydrated by drinking plenty of fluids.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Neopenem may cause dizziness or confusion in some individuals. If you experience these symptoms, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain good hygiene to prevent further infections.
- Avoid sharing personal items to prevent spread of bacteria.
- Follow a balanced diet for overall health.
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Global Brand Names
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