Neopem
Generic Name
neopem-200-mg-tablet
Manufacturer
Globex Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| neopem 200 mg tablet | ৳ 95.00 | ৳ 380.00 |
Description
Overview of the medicine
Neopem 200 mg Tablet is a broad-spectrum antibiotic used to treat a wide range of severe bacterial infections, including respiratory tract infections, urinary tract infections, and skin and soft tissue infections. It belongs to the carbapenem class of antibiotics.
Uses & Indications
Dosage
Adults
The usual adult dose is 200 mg every 8 hours, depending on the severity and site of infection, or as directed by a physician.
Elderly
No specific dose adjustment is needed for elderly patients with normal renal function. For renal impairment, dose adjustment is necessary.
Renal_impairment
Dosage adjustment is required based on creatinine clearance. For CrCl 30-50 mL/min: 200 mg every 12 hours; for CrCl 10-29 mL/min: 200 mg every 24 hours.
How to Take
Neopem 200 mg Tablet should be taken orally, with or without food. It is important to complete the full course of treatment as prescribed by the doctor, even if symptoms improve.
Mechanism of Action
Neopem inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death. It has a high stability against beta-lactamases produced by many Gram-positive and Gram-negative bacteria.
Pharmacokinetics
Onset
Typically within 1-2 hours after oral administration.
Excretion
Mainly excreted unchanged in the urine.
Half life
Approximately 1.5 - 2 hours.
Absorption
Well absorbed from the gastrointestinal tract; oral bioavailability is moderate.
Metabolism
Minimally metabolized; primarily hydrolysed in the kidney.
Side Effects
Contraindications
- Hypersensitivity to Neopem or any other carbapenem antibiotics.
- Severe hypersensitivity to other beta-lactam antibiotics (e.g., penicillins, cephalosporins).
Drug Interactions
Probenecid
Probenecid competes with Neopem for active tubular secretion, resulting in increased plasma concentrations and prolonged half-life of Neopem.
Valproic Acid
Co-administration with Neopem may decrease valproic acid plasma concentrations, potentially leading to subtherapeutic levels. Concurrent use should be avoided or monitored closely.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. Neopem can be removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Neopem is excreted in breast milk; therefore, caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to Neopem or any other carbapenem antibiotics.
- Severe hypersensitivity to other beta-lactam antibiotics (e.g., penicillins, cephalosporins).
Drug Interactions
Probenecid
Probenecid competes with Neopem for active tubular secretion, resulting in increased plasma concentrations and prolonged half-life of Neopem.
Valproic Acid
Co-administration with Neopem may decrease valproic acid plasma concentrations, potentially leading to subtherapeutic levels. Concurrent use should be avoided or monitored closely.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. Neopem can be removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Neopem is excreted in breast milk; therefore, caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Available in pharmacies and hospitals in Bangladesh
Approval Status
Approved by DGDA
Patent Status
Under patent (hypothetical)
Clinical Trials
Clinical trials for Neopem 200 mg Tablet would involve studies on its efficacy, safety, and pharmacokinetics in various patient populations and infection types. Details would be available in regulatory submissions.
Lab Monitoring
- Periodic monitoring of renal function (creatinine clearance, serum creatinine)
- Liver function tests (ALT, AST, bilirubin) in patients with hepatic impairment
- Complete blood count (CBC) during prolonged therapy
Doctor Notes
- Emphasize proper patient selection and adherence to dosage guidelines to minimize antibiotic resistance.
- Monitor patients for signs of superinfection, especially during prolonged therapy.
- Advise patients to report any unusual neurological symptoms immediately.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor and complete the full course of treatment.
- Do not stop taking Neopem even if you feel better, as this may lead to recurrent infection and antibiotic resistance.
- Inform your doctor if you experience any severe allergic reactions or persistent side effects.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Neopem may cause dizziness or seizures in some individuals. Patients should be advised to exercise caution when driving or operating machinery until they know how the drug affects them.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids.
- Avoid alcohol consumption during the treatment period as it may exacerbate side effects.
- Follow a balanced diet to support recovery.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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