Nerviplex
Generic Name
Thiamine Hydrochloride + Pyridoxine Hydrochloride + Cyanocobalamin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nerviplex 100 mg injection | ৳ 25.17 | N/A |
Description
Overview of the medicine
Nerviplex-100 mg Injection is a combination of B vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) essential for the proper functioning of the nervous system and metabolism. It is primarily used to treat and prevent conditions related to nerve damage and B-vitamin deficiencies.
Uses & Indications
Dosage
Adults
Typically 1-2 ampoules daily or on alternate days, administered deep intramuscularly, or as directed by a physician.
Elderly
No specific dosage adjustment is usually required; use with caution and under medical supervision.
Renal_impairment
No specific dosage adjustment recommended, but physician consultation is advised for severe impairment.
How to Take
Administered by deep intramuscular (IM) injection, usually into the gluteal muscle. It should be given by a healthcare professional.
Mechanism of Action
Thiamine (B1) acts as a coenzyme in carbohydrate metabolism and is crucial for nerve impulse transmission. Pyridoxine (B6) is a coenzyme in amino acid metabolism, red blood cell formation, and neurotransmitter synthesis. Cyanocobalamin (B12) is vital for DNA synthesis, myelin sheath formation around nerves, and red blood cell production.
Pharmacokinetics
Onset
Metabolic effects are observed relatively quickly, with symptomatic relief depending on the condition being treated.
Excretion
Excreted mainly via the kidneys in urine, with excess amounts being rapidly eliminated.
Half life
Variable for individual B vitamins, generally short as they are water-soluble and not stored extensively.
Absorption
Rapidly absorbed following intramuscular injection.
Metabolism
Primarily metabolized in the liver.
Side Effects
Contraindications
- •Hypersensitivity to any of the active ingredients or excipients.
- •Leber's disease (due to Cyanocobalamin, as it may cause optic nerve atrophy).
- •Undiagnosed megaloblastic anemia (B12 can mask folate deficiency).
Drug Interactions
Levodopa
Pyridoxine (B6) can reduce the efficacy of Levodopa, particularly in the absence of a peripheral dopa decarboxylase inhibitor.
Folic Acid
Large doses of folic acid can obscure the diagnosis of vitamin B12 deficiency.
Certain antibiotics (e.g., Chloramphenicol)
May interfere with the hematological response to vitamin B12.
Storage
Store below 25-30°C in a dry place, protected from light. Do not freeze.
Overdose
Overdose is rare with water-soluble vitamins as excess amounts are usually excreted. However, very high and chronic doses of Pyridoxine (B6) can lead to sensory neuropathy. Management involves discontinuing the drug and supportive care.
Pregnancy & Lactation
Consult a physician before use during pregnancy and lactation. Generally considered safe at recommended doses, but always weigh potential benefits against risks.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture, refer to product packaging for exact expiry.
Availability
Available in pharmacies, hospitals and clinics
Approval Status
Approved and widely used
Patent Status
Off-patent (for generic combination)
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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