Nerviton
Generic Name
Methylcobalamin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nerviton 500 mcg injection | ৳ 30.20 | N/A |
Description
Overview of the medicine
Nerviton 500 mcg Injection contains Methylcobalamin, a form of Vitamin B12, crucial for nerve function, red blood cell formation, and DNA synthesis. It is used to treat Vitamin B12 deficiency and associated neurological complications.
Uses & Indications
Dosage
Adults
Usually 500 mcg to 1500 mcg intramuscularly once daily or three times a week, depending on the severity of deficiency and indication. Dosage should be individualized.
Elderly
No specific dose adjustment required, but caution advised due to potential age-related decline in renal function.
Renal_impairment
No specific dose adjustment generally needed, as excretion is primarily renal but B12 is well-tolerated. However, caution for severe impairment.
How to Take
Administer intramuscularly (IM). Should be administered by a healthcare professional.
Mechanism of Action
Methylcobalamin acts as a coenzyme in two crucial metabolic pathways: the conversion of homocysteine to methionine (via methionine synthase) and the isomerization of methylmalonyl-CoA to succinyl-CoA (via methylmalonyl-CoA mutase). These pathways are vital for myelin sheath synthesis, neurological function, and DNA replication.
Pharmacokinetics
Onset
Clinical effects, especially alleviation of neurological symptoms, may take days to weeks to become apparent.
Excretion
Primarily excreted in the urine, mainly as inactive metabolites, after tissue saturation.
Half life
Plasma half-life is variable, ranging from a few hours to several days, with tissue retention being significant.
Absorption
Readily absorbed from the injection site. Peak plasma concentrations are typically reached within 1-2 hours after intramuscular administration.
Metabolism
Methylcobalamin is readily converted to other active forms of cobalamin within the body. Excess is stored in the liver.
Side Effects
Contraindications
- Hypersensitivity to Methylcobalamin or any component of the formulation
- Leber's disease (due to risk of optic nerve atrophy)
Drug Interactions
Metformin
Long-term use may lead to reduced Vitamin B12 levels.
Colchicine
May impair absorption of Vitamin B12.
Chloramphenicol
May reduce the hematological response to Vitamin B12.
Proton pump inhibitors (PPIs) & H2-receptor antagonists
May reduce gastric acid, potentially impairing B12 absorption if administered orally, but less relevant for injection.
Storage
Store in a cool, dry place, below 30°C. Protect from light. Do not freeze.
Overdose
Methylcobalamin has a very low toxicity profile. Overdose is unlikely to cause serious adverse effects. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Methylcobalamin is generally considered safe during pregnancy and lactation at recommended doses, as Vitamin B12 is essential. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to Methylcobalamin or any component of the formulation
- Leber's disease (due to risk of optic nerve atrophy)
Drug Interactions
Metformin
Long-term use may lead to reduced Vitamin B12 levels.
Colchicine
May impair absorption of Vitamin B12.
Chloramphenicol
May reduce the hematological response to Vitamin B12.
Proton pump inhibitors (PPIs) & H2-receptor antagonists
May reduce gastric acid, potentially impairing B12 absorption if administered orally, but less relevant for injection.
Storage
Store in a cool, dry place, below 30°C. Protect from light. Do not freeze.
Overdose
Methylcobalamin has a very low toxicity profile. Overdose is unlikely to cause serious adverse effects. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Methylcobalamin is generally considered safe during pregnancy and lactation at recommended doses, as Vitamin B12 is essential. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from manufacturing date.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by regulatory authorities in many countries
Patent Status
Expired for generic Methylcobalamin
WHO Essential Medicine
YesClinical Trials
Methylcobalamin has been extensively studied for its efficacy in treating various neuropathies and B12 deficiencies. Ongoing research continues to explore its role in neurological disorders.
Lab Monitoring
- Serum Vitamin B12 levels (before and during treatment)
- Complete Blood Count (CBC) with differential (especially for anemia)
- Folic acid levels (to rule out coexisting deficiency)
Doctor Notes
- Confirm B12 deficiency with laboratory tests before initiating treatment.
- Rule out Leber's disease before prescribing, especially in patients with a family history.
- Monitor patient response and B12 levels periodically.
Patient Guidelines
- Follow your doctor's instructions for dosage and administration.
- Do not stop the injection without consulting your doctor.
- Report any unusual side effects to your healthcare provider.
- Keep out of reach of children.
Missed Dose Advice
If a dose is missed, administer it as soon as possible. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Methylcobalamin injection is not known to impair the ability to drive or operate machinery. However, if you experience dizziness, avoid such activities.
Lifestyle Advice
- Maintain a balanced diet rich in Vitamin B12 (meat, fish, dairy, eggs) if possible.
- Avoid excessive alcohol consumption as it can interfere with nutrient absorption.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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