Nerviton
Generic Name
Mecobalamin (Methylcobalamin)
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nerviton 500 mcg tablet | ৳ 4.03 | ৳ 40.30 |
Description
Overview of the medicine
Mecobalamin is a vitamin B12 analogue used to treat various types of peripheral neuropathies and megaloblastic anemia. It aids in nerve tissue regeneration and maintaining healthy nerve cells.
Uses & Indications
Dosage
Adults
500 mcg to 1500 mcg daily, usually 500 mcg three times a day or 1500 mcg once daily.
Elderly
No specific dosage adjustment usually required, use with caution.
Renal_impairment
No specific dosage adjustment needed for mild to moderate impairment.
How to Take
Orally, with or without food.
Mechanism of Action
Mecobalamin is an active form of vitamin B12. It functions as a coenzyme in transmethylation reactions, particularly in the synthesis of methionine from homocysteine and the conversion of methylmalonyl-CoA to succinyl-CoA. It is essential for nerve cell growth, myelin sheath formation, and proper red blood cell maturation.
Pharmacokinetics
Onset
Varies depending on condition, but symptomatic relief can begin within weeks.
Excretion
Primarily excreted in urine, some via bile.
Half life
Approximately 6 hours.
Absorption
Well absorbed orally, peak plasma concentration reached in 3-4 hours.
Metabolism
Partially metabolized in the liver to other cobalamin forms.
Side Effects
Contraindications
- Hypersensitivity to mecobalamin or any component of the formulation
- Leber's disease (due to risk of optic nerve atrophy)
Drug Interactions
Colchicine
May reduce the absorption of mecobalamin.
Aminosalicylic acid
May reduce the absorption of mecobalamin.
Proton Pump Inhibitors (e.g., Omeprazole)
Prolonged use may reduce B12 absorption.
H2-receptor antagonists (e.g., Ranitidine)
May reduce B12 absorption.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Mecobalamin is water-soluble and generally considered safe even at high doses. No specific antidote. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Generally considered safe, but consult a doctor. Vitamin B12 is essential during pregnancy and lactation.
Side Effects
Contraindications
- Hypersensitivity to mecobalamin or any component of the formulation
- Leber's disease (due to risk of optic nerve atrophy)
Drug Interactions
Colchicine
May reduce the absorption of mecobalamin.
Aminosalicylic acid
May reduce the absorption of mecobalamin.
Proton Pump Inhibitors (e.g., Omeprazole)
Prolonged use may reduce B12 absorption.
H2-receptor antagonists (e.g., Ranitidine)
May reduce B12 absorption.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Mecobalamin is water-soluble and generally considered safe even at high doses. No specific antidote. Symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Generally considered safe, but consult a doctor. Vitamin B12 is essential during pregnancy and lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies nationwide
Approval Status
Approved
Patent Status
Generic
Clinical Trials
Ongoing research for wider applications in neurological disorders.
Lab Monitoring
- Serum B12 levels (for deficiency)
- CBC (for anemia)
- Methylmalonic acid and Homocysteine levels (to confirm B12 deficiency)
Doctor Notes
- Advise patients on dietary sources of B12.
- Monitor patients with Leber's disease cautiously.
- Educate patients on drug interactions, especially with PPIs and H2 blockers.
Patient Guidelines
- Take as directed by your doctor.
- Do not stop taking the medicine without consulting your doctor.
- Inform your doctor if you experience any unusual symptoms.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
No known effects on the ability to drive or operate machinery.
Lifestyle Advice
- Maintain a balanced diet rich in B12 sources (meat, fish, dairy, eggs).
- Avoid excessive alcohol consumption as it can impair B12 absorption.
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