Neso
Generic Name
Naproxen
Manufacturer
Reputable Pharmaceutical Company
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| neso 375 mg tablet | ৳ 13.00 | ৳ 130.00 |
Description
Overview of the medicine
Neso 375 mg Tablet contains Naproxen, a non-steroidal anti-inflammatory drug (NSAID), used for pain relief, reducing inflammation, and fever.
Uses & Indications
Dosage
Adults
For Rheumatoid Arthritis, Osteoarthritis, Ankylosing Spondylitis: 250 mg to 500 mg twice daily. For acute gout: 750 mg orally, followed by 250 mg every 8 hours until the attack subsides. For mild to moderate pain, dysmenorrhea: 500 mg initially, then 250 mg every 6-8 hours as needed. Maximum dose: 1250 mg/day.
Elderly
Lower doses may be required due to increased risk of adverse effects. Consider 250 mg twice daily, and adjust based on renal function and tolerability.
Renal_impairment
Use with caution; a lower total daily dose should be considered and patients monitored closely.
How to Take
Take orally with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water.
Mechanism of Action
Naproxen inhibits cyclooxygenase (COX-1 and COX-2) enzymes, which are responsible for the synthesis of prostaglandins. Prostaglandins mediate inflammation, pain, and fever. By inhibiting their synthesis, Naproxen reduces these symptoms.
Pharmacokinetics
Onset
Pain relief usually starts within 1 hour.
Excretion
Primarily excreted in the urine (about 95%), mainly as metabolites and conjugates.
Half life
Approximately 12-17 hours.
Absorption
Well absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 2-4 hours.
Metabolism
Extensively metabolized in the liver by demethylation and glucuronidation.
Side Effects
Contraindications
- Hypersensitivity to Naproxen or other NSAIDs
- Asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe heart failure
- Severe renal impairment
- Severe hepatic impairment
- Third trimester of pregnancy
- Coronary Artery Bypass Graft (CABG) surgery
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
ACE Inhibitors/ARBs
Reduced antihypertensive effect and increased risk of renal impairment.
Other NSAIDs or Aspirin
Increased risk of gastrointestinal adverse effects.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effects.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, heartburn, indigestion, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves symptomatic and supportive care. Gastric lavage and activated charcoal may be considered if ingestion is recent.
Pregnancy & Lactation
Avoid during the third trimester of pregnancy due to risk of premature closure of the fetal ductus arteriosus. Use only if clearly needed during the first and second trimesters, with caution. Small amounts of Naproxen pass into breast milk; consult a doctor before use during lactation.
Side Effects
Contraindications
- Hypersensitivity to Naproxen or other NSAIDs
- Asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe heart failure
- Severe renal impairment
- Severe hepatic impairment
- Third trimester of pregnancy
- Coronary Artery Bypass Graft (CABG) surgery
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
ACE Inhibitors/ARBs
Reduced antihypertensive effect and increased risk of renal impairment.
Other NSAIDs or Aspirin
Increased risk of gastrointestinal adverse effects.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effects.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, heartburn, indigestion, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves symptomatic and supportive care. Gastric lavage and activated charcoal may be considered if ingestion is recent.
Pregnancy & Lactation
Avoid during the third trimester of pregnancy due to risk of premature closure of the fetal ductus arteriosus. Use only if clearly needed during the first and second trimesters, with caution. Small amounts of Naproxen pass into breast milk; consult a doctor before use during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Naproxen has undergone extensive clinical trials supporting its efficacy and safety for various indications. Ongoing post-market surveillance continues to monitor its long-term effects.
Lab Monitoring
- Complete Blood Count (CBC) for prolonged use
- Liver Function Tests (LFTs)
- Renal Function Tests (RFTs) (BUN, creatinine)
- Blood pressure monitoring
Doctor Notes
- Advise patients to take the lowest effective dose for the shortest duration consistent with individual patient goals.
- Counsel patients on GI and CV risks, especially in high-risk populations.
- Periodically assess the need for continued therapy, particularly in chronic conditions.
Patient Guidelines
- Take with food or milk to prevent stomach upset.
- Do not exceed the recommended dose.
- Avoid alcohol while taking this medicine.
- Report any signs of stomach bleeding (e.g., black, tarry stools) immediately.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
May cause dizziness or drowsiness. If affected, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain a healthy diet to support overall well-being.
- Engage in moderate exercise regularly as advised by your physician for inflammatory conditions.
- Avoid smoking, as it may worsen gastrointestinal risks.
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