Neso
Generic Name
neso-500-mg-tablet
Manufacturer
Hypothetical Pharma Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| neso 500 mg tablet | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Neso-500 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) containing Naproxen. It is used for the relief of mild to moderate pain, inflammation, and fever associated with various conditions such as arthritis, menstrual cramps, muscle aches, and dental pain.
Uses & Indications
Dosage
Adults
For mild to moderate pain, initial dose 500 mg followed by 250 mg every 6-8 hours as needed, not exceeding 1250 mg on the first day and 1000 mg/day thereafter. For chronic conditions (e.g., arthritis), 250 mg to 500 mg twice daily. Maximum daily dose is generally 1000 mg.
Elderly
Use with caution; lower doses may be necessary due to increased risk of adverse effects. Consider 250 mg twice daily initially.
Renal_impairment
Not recommended in severe renal impairment (creatinine clearance < 30 mL/min). For moderate impairment, dose reduction may be necessary, and close monitoring of renal function is advised.
How to Take
Take orally with a full glass of water, preferably with food or milk to minimize gastrointestinal upset. Do not crush, chew, or break the tablet.
Mechanism of Action
Neso-500 mg (Naproxen) works by inhibiting the activity of cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2. These enzymes are responsible for the synthesis of prostaglandins, which are mediators of pain, inflammation, and fever. By reducing prostaglandin production, Naproxen effectively reduces these symptoms.
Pharmacokinetics
Onset
Pain relief typically begins within 1 hour, with maximal effect seen at 2-4 hours.
Excretion
About 95% is excreted in the urine, mainly as unchanged naproxen, 6-O-desmethylnaproxen, and their conjugates. A small amount is excreted in feces.
Half life
Approximately 12-17 hours.
Absorption
Well absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 2-4 hours after oral administration.
Metabolism
Primarily metabolized in the liver by the cytochrome P450 system (CYP2C9) to 6-O-desmethylnaproxen, and then extensively conjugated to glucuronide derivatives.
Side Effects
Contraindications
- Known hypersensitivity to Naproxen or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Severe heart failure
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Diuretics
Reduced diuretic and antihypertensive effects, increased risk of renal impairment.
Methotrexate
Increased plasma methotrexate levels, enhancing toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
ACE inhibitors/ARBs
Reduced antihypertensive effect and increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, heartburn, nausea, vomiting, epigastric pain, and rarely gastrointestinal bleeding. Management involves supportive and symptomatic treatment, including gastric lavage or activated charcoal if ingestion is recent. Close monitoring of vital signs and renal function is crucial.
Pregnancy & Lactation
Not recommended during pregnancy, especially during the third trimester, due to potential risks to the fetus (e.g., premature closure of the ductus arteriosus). Avoid during lactation as Naproxen is excreted in breast milk and may cause adverse effects in infants.
Side Effects
Contraindications
- Known hypersensitivity to Naproxen or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Severe heart failure
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Diuretics
Reduced diuretic and antihypertensive effects, increased risk of renal impairment.
Methotrexate
Increased plasma methotrexate levels, enhancing toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
ACE inhibitors/ARBs
Reduced antihypertensive effect and increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, heartburn, nausea, vomiting, epigastric pain, and rarely gastrointestinal bleeding. Management involves supportive and symptomatic treatment, including gastric lavage or activated charcoal if ingestion is recent. Close monitoring of vital signs and renal function is crucial.
Pregnancy & Lactation
Not recommended during pregnancy, especially during the third trimester, due to potential risks to the fetus (e.g., premature closure of the ductus arteriosus). Avoid during lactation as Naproxen is excreted in breast milk and may cause adverse effects in infants.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Available in pharmacies nationwide
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
As an established drug, Naproxen has undergone extensive clinical trials demonstrating its efficacy and safety profile in various indications. Ongoing post-market surveillance continues to monitor its use.
Lab Monitoring
- Complete Blood Count (CBC): Periodically for long-term therapy to monitor for anemia and other blood dyscrasias.
- Renal Function Tests (serum creatinine, BUN): Regularly, especially in elderly or patients with pre-existing renal impairment.
- Liver Function Tests (ALT, AST): Periodically for long-term therapy or in patients with liver conditions.
- Blood pressure: Regularly, as NSAIDs can cause new onset or worsening hypertension.
Doctor Notes
- Monitor for GI toxicity, including ulcers and bleeding, especially in elderly patients or those with a history of GI issues.
- Assess cardiovascular risk factors before prescribing and monitor blood pressure during treatment.
- Regularly assess renal function, particularly in patients with pre-existing impairment or those on diuretics/ACE inhibitors.
- Use the lowest effective dose for the shortest duration necessary.
Patient Guidelines
- Take Neso-500 mg with food or milk to reduce stomach upset.
- Do not exceed the recommended dose or duration of treatment.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
- Report any signs of stomach bleeding (e.g., black or bloody stools, severe stomach pain) or allergic reactions immediately.
- Avoid alcohol consumption while taking this medicine.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
May cause dizziness, drowsiness, or visual disturbances. Patients should be cautioned about operating hazardous machinery or driving if they experience these effects.
Lifestyle Advice
- Maintain adequate hydration, especially if you are elderly or have kidney problems.
- Limit alcohol intake as it can increase the risk of stomach irritation and bleeding.
- If taking for chronic conditions, regular exercise and physical therapy can complement treatment.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Neso Brand
Other medicines available under the same brand name
