Nesotem
Generic Name
Acyclovir
Manufacturer
Hypothetical Pharma Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
Variant | Unit Price | Strip Price |
---|---|---|
nesotem 375 mg tablet | ৳ 12.00 | ৳ 48.00 |
Description
Overview of the medicine
Nesotem 375 mg Tablet contains Acyclovir, an antiviral drug used to treat infections caused by herpes simplex virus (HSV), varicella-zoster virus (VZV), and other related viruses. It helps manage symptoms and reduces the frequency and severity of outbreaks.
Uses & Indications
Dosage
Adults
For specific viral infections (e.g., severe initial genital herpes or mild zoster): 375 mg (one tablet) three times daily for 7-10 days, or as directed by physician. Dosing may vary significantly based on indication and patient's condition.
Elderly
Dose reduction may be necessary due to age-related decline in renal function. Consult a physician for appropriate dosing.
Renal_impairment
Significant dosage adjustment required based on creatinine clearance. For severe impairment (CrCl <10 mL/min), dose reduction is essential. Always consult a physician.
How to Take
Nesotem 375 mg Tablet may be taken with or without food. Swallow the tablet whole with water. Do not crush or chew.
Mechanism of Action
Acyclovir is a synthetic purine nucleoside analogue. It is converted to its active triphosphate form by viral thymidine kinase, which is much more efficient in herpes virus-infected cells. Acyclovir triphosphate then inhibits viral DNA synthesis by competing with deoxyguanosine triphosphate for viral DNA polymerase, incorporating into viral DNA, and causing chain termination.
Pharmacokinetics
Onset
Varies by condition; typically within 24-48 hours for symptom improvement.
Excretion
Primarily excreted unchanged by the kidneys via glomerular filtration and tubular secretion.
Half life
Approximately 2.5-3.3 hours in adults with normal renal function.
Absorption
Bioavailability is low (10-30%) and decreases with increasing dose. Food does not significantly affect absorption.
Metabolism
Partially metabolized by aldehyde oxidase to an inactive metabolite (9-carboxymethoxymethylguanine).
Side Effects
Contraindications
- Hypersensitivity to acyclovir, valacyclovir, or any component of the formulation.
- Severe renal impairment without appropriate dose adjustment.
Drug Interactions
Probenecid
Increases acyclovir plasma concentration and prolongs its half-life by reducing renal tubular secretion.
Nephrotoxic drugs
Concomitant administration with other nephrotoxic drugs may increase the risk of renal dysfunction. Close monitoring is advised.
Mycophenolate Mofetil
Increased plasma concentrations of both mycophenolate mofetil and acyclovir.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, diarrhea, headache, confusion, and renal dysfunction. Management is primarily supportive; hemodialysis may be considered in severe cases, especially in patients with pre-existing renal impairment.
Pregnancy & Lactation
Acyclovir should be used during pregnancy only if the potential benefits outweigh the potential risks to the fetus. It is excreted into breast milk; caution should be exercised when administered to a nursing mother. Consult your doctor.
Side Effects
Contraindications
- Hypersensitivity to acyclovir, valacyclovir, or any component of the formulation.
- Severe renal impairment without appropriate dose adjustment.
Drug Interactions
Probenecid
Increases acyclovir plasma concentration and prolongs its half-life by reducing renal tubular secretion.
Nephrotoxic drugs
Concomitant administration with other nephrotoxic drugs may increase the risk of renal dysfunction. Close monitoring is advised.
Mycophenolate Mofetil
Increased plasma concentrations of both mycophenolate mofetil and acyclovir.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, diarrhea, headache, confusion, and renal dysfunction. Management is primarily supportive; hemodialysis may be considered in severe cases, especially in patients with pre-existing renal impairment.
Pregnancy & Lactation
Acyclovir should be used during pregnancy only if the potential benefits outweigh the potential risks to the fetus. It is excreted into breast milk; caution should be exercised when administered to a nursing mother. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Pharmacies, hospitals
Approval Status
Approved by major regulatory bodies
Patent Status
Expired for generic Acyclovir
WHO Essential Medicine
YesClinical Trials
Acyclovir has undergone extensive clinical trials demonstrating its efficacy and safety in various herpes virus infections, leading to its widespread approval and use globally.
Lab Monitoring
- Renal function (BUN, creatinine) in patients with impaired renal function or those receiving high doses.
- Liver function tests (LFTs) periodically, especially in patients with pre-existing hepatic impairment.
Doctor Notes
- Emphasize the importance of adequate hydration to prevent renal complications, especially in elderly or renally impaired patients.
- Counsel patients that acyclovir therapy is suppressive, not curative, for herpes infections and does not prevent transmission entirely.
- Monitor renal function, especially with concomitant use of other nephrotoxic agents.
Patient Guidelines
- Complete the full prescribed course of treatment even if symptoms improve to prevent recurrence and resistance.
- Stay well hydrated, especially during high-dose therapy, to help prevent kidney problems.
- Nesotem does not cure herpes; it helps manage symptoms and reduce the frequency and severity of outbreaks.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double dose to make up for a missed one.
Driving Precautions
Nesotem 375 mg Tablet may cause dizziness or drowsiness in some individuals. Use caution when driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Avoid sharing personal items like towels, lip balm, or eating utensils during outbreaks to prevent viral transmission.
- Practice safe sex, including using condoms, to reduce the risk of genital herpes transmission to partners.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Nesotem Brand
Other medicines available under the same brand name