Nesotem
Generic Name
Nesotem
Manufacturer
MediCorp Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nesotem 500 mg tablet | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Nesotem 500 mg tablet is a broad-spectrum antibiotic used to treat various bacterial infections.
Uses & Indications
Dosage
Adults
500 mg once daily for 7-10 days, depending on the type and severity of infection.
Elderly
No dose adjustment is typically needed for elderly patients with normal renal function.
Renal_impairment
Dose reduction advised for patients with creatinine clearance (CrCl) < 30 mL/min.
How to Take
Nesotem can be taken with or without food. Swallow the tablet whole with water; do not crush or chew.
Mechanism of Action
Nesotem works by inhibiting bacterial DNA synthesis or cell wall formation, leading to bacterial cell death.
Pharmacokinetics
Onset
Therapeutic effects typically begin within 30-60 minutes after administration.
Excretion
Primarily excreted by the kidneys, with a significant portion excreted unchanged in urine.
Half life
The elimination half-life is approximately 6-8 hours, allowing for once or twice daily dosing.
Absorption
Rapidly absorbed from the gastrointestinal tract, achieving peak plasma concentrations within 1-2 hours.
Metabolism
Undergoes minor hepatic metabolism, with most of the drug excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to Nesotem or any components of the formulation
- History of tendinitis or tendon rupture associated with fluoroquinolone use
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin, requiring close monitoring of INR and prothrombin time.
Theophylline
Potential for increased plasma levels of theophylline, leading to toxicity. Monitor theophylline levels.
Antacids (containing aluminum, magnesium, calcium)
May significantly decrease the absorption of Nesotem. Administer Nesotem at least 2 hours before or 6 hours after antacids.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. Gastric lavage and activated charcoal may be considered. Hemodialysis is not effective in removing Nesotem.
Pregnancy & Lactation
Category C. Consult a doctor before use. Nesotem should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk; caution is advised during breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to Nesotem or any components of the formulation
- History of tendinitis or tendon rupture associated with fluoroquinolone use
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin, requiring close monitoring of INR and prothrombin time.
Theophylline
Potential for increased plasma levels of theophylline, leading to toxicity. Monitor theophylline levels.
Antacids (containing aluminum, magnesium, calcium)
May significantly decrease the absorption of Nesotem. Administer Nesotem at least 2 hours before or 6 hours after antacids.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. Gastric lavage and activated charcoal may be considered. Hemodialysis is not effective in removing Nesotem.
Pregnancy & Lactation
Category C. Consult a doctor before use. Nesotem should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk; caution is advised during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by regulatory authorities
Patent Status
Patent Expired
WHO Essential Medicine
YesClinical Trials
Nesotem has undergone extensive Phase I, II, and III clinical trials demonstrating its efficacy and safety profile in various bacterial infections.
Lab Monitoring
- Complete blood count (CBC) during prolonged therapy
- Renal function (creatinine, BUN) for patients with pre-existing impairment
- Liver function tests (ALT, AST) if signs of hepatic dysfunction occur
Doctor Notes
- Emphasize the importance of patient compliance to complete the entire course to prevent resistance.
- Monitor patients for signs of C. difficile infection if diarrhea occurs during or after treatment.
- Advise patients about potential photosensitivity and to use sun protection.
Patient Guidelines
- Complete the full course of medication as prescribed, even if symptoms improve.
- Do not share this medication with others, even if they have similar symptoms.
- Report any severe side effects, especially tendon pain or swelling, immediately to your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Driving Precautions
Nesotem may cause dizziness or lightheadedness. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Stay well-hydrated by drinking plenty of fluids.
- Avoid excessive sun exposure as Nesotem may increase photosensitivity.
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Global Brand Names
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