Neumig
Generic Name
Flunarizine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| neumig 10 mg tablet | ৳ 35.00 | ৳ 350.00 |
Description
Overview of the medicine
Flunarizine is a selective calcium entry blocker and histamine H1 antagonist, primarily used for the prophylaxis of migraine and symptomatic treatment of vertigo and dizziness.
Uses & Indications
Dosage
Adults
Migraine prophylaxis: Initial dose is 5 mg daily at bedtime. If insufficient, may increase to 10 mg daily at bedtime. Vertigo: 5-10 mg daily at bedtime.
Elderly
Start with 5 mg daily at bedtime due to potential for increased sensitivity and side effects.
Renal_impairment
No specific dose adjustment is generally required, but caution is advised in severe impairment due to metabolic excretion.
How to Take
Take orally, usually once daily at bedtime. It can be taken with or without food.
Mechanism of Action
Flunarizine selectively blocks calcium entry into vascular smooth muscle cells and erythrocyte membranes, thus preventing vasoconstriction and improving microcirculatory blood flow. It also has H1 antagonistic activity.
Pharmacokinetics
Onset
Therapeutic effects for migraine prophylaxis may take several weeks (e.g., 6-8 weeks) to become apparent.
Excretion
Primarily excreted in the feces via biliary excretion (about 60%), with a small amount excreted renally (<1%).
Half life
Long elimination half-life, ranging from 18 to 23 days, allowing for once-daily dosing.
Absorption
Well absorbed from the gastrointestinal tract (bioavailability > 80%). Peak plasma concentrations are reached within 2-4 hours.
Metabolism
Extensively metabolized in the liver, primarily via CYP2D6 and CYP3A4, with significant first-pass effect.
Side Effects
Contraindications
- Hypersensitivity to flunarizine or any component of the tablet.
- Patients with a history of depressive illness or pre-existing Parkinson's disease or other extrapyramidal disorders.
Drug Interactions
Oral Contraceptives
May cause galactorrhea in some women, though the mechanism is not fully understood.
Sedatives, Hypnotics, Alcohol
Concomitant use may lead to increased sedation.
Phenytoin, Carbamazepine, Valproate
These antiepileptics may decrease plasma concentrations of flunarizine.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include sedation, drowsiness, bradycardia, and tachycardia. Treatment is supportive, including gastric lavage and activated charcoal if overdose is recent.
Pregnancy & Lactation
Pregnancy Category C. Should only be used if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it may be excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to flunarizine or any component of the tablet.
- Patients with a history of depressive illness or pre-existing Parkinson's disease or other extrapyramidal disorders.
Drug Interactions
Oral Contraceptives
May cause galactorrhea in some women, though the mechanism is not fully understood.
Sedatives, Hypnotics, Alcohol
Concomitant use may lead to increased sedation.
Phenytoin, Carbamazepine, Valproate
These antiepileptics may decrease plasma concentrations of flunarizine.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include sedation, drowsiness, bradycardia, and tachycardia. Treatment is supportive, including gastric lavage and activated charcoal if overdose is recent.
Pregnancy & Lactation
Pregnancy Category C. Should only be used if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it may be excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date, depending on manufacturer specifications.
Availability
Pharmacies, Hospitals
Approval Status
Approved (e.g., DGDA, FDA for active ingredient)
Patent Status
Off-patent
Clinical Trials
Flunarizine has been extensively studied in clinical trials for migraine prophylaxis and vertigo, demonstrating its efficacy and safety profile.
Lab Monitoring
- No routine laboratory monitoring is required. However, monitor for the emergence or worsening of depressive symptoms or extrapyramidal symptoms during treatment.
Doctor Notes
- Assess for history of depression or Parkinson's disease before initiating therapy.
- Monitor patients for depressive symptoms and extrapyramidal symptoms, especially during the first few months of treatment.
- Re-evaluate efficacy after 2-3 months; if no response, consider discontinuing treatment.
Patient Guidelines
- Take this medicine at bedtime to minimize daytime drowsiness.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Report any mood changes, depression, or unusual movements to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. Do not take a double dose to make up for a forgotten one.
Driving Precautions
Flunarizine may cause drowsiness or sedation, especially at the start of treatment. Exercise caution when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Maintain a regular sleep schedule.
- Avoid known migraine triggers like certain foods, stress, and lack of sleep.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Neumig Brand
Other medicines available under the same brand name
