Neumig
Generic Name
Flunarizine
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| neumig 5 mg tablet | ৳ 20.00 | ৳ 200.00 |
Description
Overview of the medicine
Neumig 5 mg Tablet contains Flunarizine, a selective calcium channel blocker, primarily used for the prophylaxis of migraine and symptomatic treatment of vertigo and dizziness of vestibular origin.
Uses & Indications
Dosage
Adults
For migraine prophylaxis: Initially 5 mg once daily at bedtime. If no improvement after 2 months, treatment should be stopped. For vertigo: 5-10 mg once daily at bedtime, depending on response.
Elderly
5 mg once daily at bedtime. If no improvement after 1 month, treatment should be stopped. Special caution is advised due to increased risk of extrapyramidal symptoms.
Renal_impairment
No specific dose adjustment is usually required, but caution is advised in severe renal impairment.
How to Take
Take orally, preferably at bedtime, with or without food. Do not chew or crush the tablet.
Mechanism of Action
Flunarizine selectively blocks calcium entry into cells, reducing excessive influx of calcium. It stabilizes cell membranes, prevents vasoconstriction and hypoxia-induced damage, particularly in cerebral vessels. It also exhibits antihistaminic and antidopaminergic properties.
Pharmacokinetics
Onset
Anti-migraine effect is gradual, usually observed after several weeks of continuous treatment. Vertigo relief can be earlier.
Excretion
Primarily excreted via feces, with minor renal excretion.
Half life
Long, with a terminal elimination half-life of approximately 18-23 days.
Absorption
Well absorbed from the gastrointestinal tract after oral administration.
Metabolism
Extensively metabolized in the liver, primarily via CYP2D6.
Side Effects
Contraindications
- History of depressive illness or active depression
- History of Parkinson's disease or other extrapyramidal disorders
- Known hypersensitivity to flunarizine or any excipients
- Acute porphyria
Drug Interactions
Oral Contraceptives
Cases of galactorrhea have been reported when flunarizine was co-administered with oral contraceptives.
Sedatives/Hypnotics/Alcohol
May enhance the sedative effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include sedation, bradycardia, and tachycardia. Treatment is supportive and symptomatic; gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Avoid during lactation as flunarizine may be excreted in breast milk.
Side Effects
Contraindications
- History of depressive illness or active depression
- History of Parkinson's disease or other extrapyramidal disorders
- Known hypersensitivity to flunarizine or any excipients
- Acute porphyria
Drug Interactions
Oral Contraceptives
Cases of galactorrhea have been reported when flunarizine was co-administered with oral contraceptives.
Sedatives/Hypnotics/Alcohol
May enhance the sedative effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include sedation, bradycardia, and tachycardia. Treatment is supportive and symptomatic; gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Avoid during lactation as flunarizine may be excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, refer to product packaging for exact date.
Availability
Available in pharmacies
Approval Status
Approved in Bangladesh
Patent Status
Off-patent
Clinical Trials
Flunarizine has undergone numerous clinical trials demonstrating its efficacy in migraine prophylaxis and vertigo treatment. Studies focus on dose-response, long-term safety, and comparison with other prophylactic agents.
Lab Monitoring
- No routine lab monitoring is generally required. However, monitor for signs of depression or extrapyramidal symptoms.
Doctor Notes
- Counsel patients on potential central nervous system side effects including drowsiness and depression.
- Monitor for the emergence or worsening of extrapyramidal symptoms, particularly in elderly patients.
- Discuss the potential for weight gain and advise on lifestyle modifications.
- Re-evaluate treatment periodically; if no improvement after 2 months (for migraine) or 1 month (for elderly), discontinue.
Patient Guidelines
- Take the medicine regularly as prescribed, preferably at bedtime.
- Do not stop treatment abruptly without consulting your doctor.
- Be aware of potential side effects like drowsiness and weight gain.
- Report any mood changes or movement problems to your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Neumig may cause drowsiness, especially at the start of treatment. Avoid driving or operating heavy machinery until you know how the medicine affects you.
Lifestyle Advice
- Avoid alcohol while taking this medicine.
- Maintain a healthy diet and exercise to manage potential weight gain.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Neumig Brand
Other medicines available under the same brand name
