Medicine Information

Neurolin-CR

Name: Neurolin-CR
Brand: Neurolin-CR
Rating: 4.5 (117 reviews)

Tablet (Controlled Release)165 mgAnticonvulsants, Analgesics (Neuropathic Pain)ATC: N03AX16

Generic Name

Pregabalin Controlled Release

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
neurolin cr 165 mg tablet	৳ 35.00	৳ 210.00

Description

Overview of the medicine

Neurolin-CR 165 mg Tablet is a controlled-release formulation of Pregabalin, primarily used for the management of neuropathic pain, fibromyalgia, and as an adjunctive therapy for partial onset seizures.

Uses & Indications

Neuropathic pain (diabetic peripheral neuropathy, post-herpetic neuralgia)

Fibromyalgia

Adjunctive therapy for partial onset seizures in adults

Dosage

Adults

For neuropathic pain, typically initiated with 165 mg once daily. Dosage may be increased based on response and tolerability, up to a maximum of 330 mg once daily. For fibromyalgia, start with 165 mg once daily, may increase to 330 mg once daily.

Elderly

Dose adjustments may be necessary due to age-related decline in renal function. Start with a lower dose and titrate cautiously.

Renal_impairment

Significant dose adjustment is required based on creatinine clearance. For CrCl 30-60 mL/min, 82.5 mg once daily. For CrCl <30 mL/min, 50 mg every other day.

How to Take

Take orally with or without food. Swallow the tablet whole; do not crush, chew, or split it.

Mechanism of Action

Pregabalin binds with high affinity to the alpha2-delta (α2-δ) subunit of voltage-gated calcium channels in the central nervous system. This binding modulates the release of several excitatory neurotransmitters, thereby exerting its analgesic, anxiolytic, and anticonvulsant effects.

Pharmacokinetics

Onset

Analgesic effects for neuropathic pain may be observed within one week of initiation.

Excretion

Primarily excreted unchanged in the urine (approximately 98% of the dose).

Half life

Approximately 6.3 hours. The controlled-release formulation extends the duration of action.

Absorption

Rapidly absorbed after oral administration, with controlled-release formulations designed for sustained absorption. Bioavailability is ≥90% and is not affected by food.

Metabolism

Negligible metabolism in humans; less than 0.1% of the dose is metabolized.

Side Effects

Contraindications

Hypersensitivity to pregabalin or any component of the formulation.

Drug Interactions

CNS Depressants (e.g., opioids, benzodiazepines, alcohol)

May enhance the central nervous system (CNS) depressant effects, including sedation and somnolence.

Thiazolidinedione Antidiabetics (e.g., rosiglitazone, pioglitazone)

May increase the risk of edema and weight gain, especially in patients with pre-existing cardiac conditions.

Storage

Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include somnolence, confusion, agitation, and in rare cases, coma. Treatment is supportive and symptomatic; hemodialysis may be considered in severe cases as pregabalin is hemodialyzable.

Pregnancy & Lactation

Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Pregabalin is excreted in human milk; caution is advised when administered to a nursing woman.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per pack30 tablets per pack

Shelf Life

24-36 months from manufacturing date.

Availability

Available in pharmacies and hospitals

Approval Status

Approved by regulatory authorities (e.g., DGDA)

Patent Status

Patent expired, generic versions available

Clinical Trials

Extensive clinical trials have demonstrated the efficacy and safety of pregabalin in treating neuropathic pain, fibromyalgia, and as an adjunctive treatment for partial onset seizures.

Lab Monitoring

Routine laboratory monitoring is generally not required. Renal function should be monitored in patients with pre-existing renal impairment.

Doctor Notes

Initiate therapy with a low dose and titrate slowly to minimize adverse effects.
Monitor patients for signs of CNS depression, suicidal ideation, and abuse potential.
Counsel patients on the importance of not abruptly discontinuing the medication to avoid withdrawal symptoms.
Adjust dose in patients with renal impairment.

Patient Guidelines

Take the medicine exactly as prescribed by your doctor.
Do not stop taking the medicine suddenly without consulting your doctor, as this may lead to withdrawal symptoms.
Avoid alcohol consumption while on this medication, as it can increase side effects.
Report any unusual mood or behavior changes, including suicidal thoughts, to your doctor immediately.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

This medicine may cause dizziness, somnolence, or blurred vision. Do not drive or operate machinery until you know how Neurolin-CR affects you and are sure it does not impair your ability.

Lifestyle Advice

Avoid activities requiring mental alertness, such as driving or operating heavy machinery, until you know how this medicine affects you. Manage weight if you experience weight gain.
Maintain good hydration.