Neurolin-CR
Generic Name
Gabapentin Extended-Release 825 mg Tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| neurolin cr 825 mg tablet | ৳ 25.00 | ৳ 250.00 |
Description
Overview of the medicine
Neurolin-CR 825 mg Tablet contains Gabapentin Extended-Release and is primarily used for the management of postherpetic neuralgia and sometimes as an adjunctive therapy for partial seizures. The controlled-release formulation allows for once-daily dosing.
Uses & Indications
Dosage
Adults
For Postherpetic Neuralgia: Initial dose typically 300 mg once daily on Day 1, then titrated gradually. For Neurolin-CR 825 mg, it may be a maintenance dose, usually taken once daily with the evening meal. Do not exceed 3600 mg/day.
Elderly
Dosage should be adjusted based on renal function due to potential age-related decline in kidney function.
Renal_impairment
Dose must be reduced in patients with impaired renal function (creatinine clearance <60 mL/min). Specific dosing adjustments are required based on creatinine clearance.
How to Take
Take Neurolin-CR 825 mg Tablet orally, preferably with the evening meal, as directed by your physician. Do not crush, chew, or break the tablet; swallow it whole.
Mechanism of Action
The exact mechanism of gabapentin is not fully understood. It is believed to bind with high affinity to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, which may modulate the release of excitatory neurotransmitters involved in neuropathic pain and seizure activity.
Pharmacokinetics
Onset
Therapeutic effects may be observed within a few days to weeks of initiating therapy.
Excretion
Eliminated unchanged primarily by renal excretion.
Half life
Approximately 5-7 hours in individuals with normal renal function, but the extended-release formulation prolongs the duration of action.
Absorption
Oral absorption is dose-dependent and saturable; not proportional to the dose administered. Peak plasma concentrations are reached in approximately 6-8 hours with the extended-release formulation. Food increases absorption.
Metabolism
Gabapentin is not significantly metabolized in humans.
Side Effects
Contraindications
- •Known hypersensitivity to gabapentin or any components of the formulation.
Drug Interactions
Ethanol
May increase CNS depressant effects of gabapentin.
Antacids
Antacids containing aluminum or magnesium may reduce gabapentin bioavailability. Take gabapentin at least 2 hours after antacid administration.
Opioids (e.g., Morphine)
May increase gabapentin levels and enhance CNS depressant effects. Monitor for increased sedation and respiratory depression.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include dizziness, double vision, slurred speech, drowsiness, lethargy, and mild diarrhea. Supportive care and symptomatic treatment are recommended. Gabapentin can be removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category C. Gabapentin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in human milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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