Neuroson
Generic Name
Thiamine Hydrochloride + Pyridoxine Hydrochloride + Cyanocobalamin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| neuroson 100 mg tablet | ৳ 8.00 | N/A |
Description
Overview of the medicine
Neuroson is a combination of essential B vitamins (B1, B6, B12) crucial for nerve function and overall metabolic health. It is often used to treat and prevent B vitamin deficiencies, particularly those associated with neurological symptoms.
Uses & Indications
Dosage
Adults
1-2 tablets daily, or as directed by the physician.
Elderly
Same as adult dosage, or as advised by a physician.
Renal_impairment
No specific dose adjustment is usually required, but consult a physician.
How to Take
Oral tablets should be swallowed whole with water, preferably with a meal to minimize gastrointestinal discomfort.
Mechanism of Action
Thiamine (B1) acts as a coenzyme in carbohydrate metabolism. Pyridoxine (B6) is essential for amino acid metabolism, neurotransmitter synthesis, and myelin formation. Cyanocobalamin (B12) is vital for DNA synthesis, red blood cell formation, and maintaining nerve cell health.
Pharmacokinetics
Onset
Therapeutic effects may be noticed within days to weeks depending on the severity of deficiency.
Excretion
Primarily excreted in urine; excess B12 is stored in the liver.
Half life
Thiamine: 18-22 hours, Pyridoxine: 15-20 days, Cyanocobalamin: 6 days (elimination).
Absorption
Well absorbed from the gastrointestinal tract; absorption of B12 is dependent on intrinsic factor.
Metabolism
Metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to any component of the formulation.
- Patients with pernicious anemia (B12 deficiency diagnosis may be masked).
Drug Interactions
Levodopa
Pyridoxine (B6) can reduce the efficacy of levodopa, especially without a dopa-decarboxylase inhibitor.
Phenobarbital, Phenytoin
High doses of pyridoxine may reduce serum concentrations of these anticonvulsants.
Colchicine, Neomycin, Aminosalicylic acid
May impair intestinal absorption of Cyanocobalamin (B12).
Isoniazid, Penicillamine, Oral Contraceptives
These drugs can increase pyridoxine requirements.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture.
Overdose
Neuroson has low toxicity. Very high doses of pyridoxine (B6) for prolonged periods may lead to peripheral neuropathy. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Generally considered safe during pregnancy and lactation at recommended doses, as B vitamins are essential for fetal development and breast milk. However, consult a physician before use.
Side Effects
Contraindications
- Hypersensitivity to any component of the formulation.
- Patients with pernicious anemia (B12 deficiency diagnosis may be masked).
Drug Interactions
Levodopa
Pyridoxine (B6) can reduce the efficacy of levodopa, especially without a dopa-decarboxylase inhibitor.
Phenobarbital, Phenytoin
High doses of pyridoxine may reduce serum concentrations of these anticonvulsants.
Colchicine, Neomycin, Aminosalicylic acid
May impair intestinal absorption of Cyanocobalamin (B12).
Isoniazid, Penicillamine, Oral Contraceptives
These drugs can increase pyridoxine requirements.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture.
Overdose
Neuroson has low toxicity. Very high doses of pyridoxine (B6) for prolonged periods may lead to peripheral neuropathy. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Generally considered safe during pregnancy and lactation at recommended doses, as B vitamins are essential for fetal development and breast milk. However, consult a physician before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Available in all pharmacies in Bangladesh
Approval Status
Approved by DGDA
Patent Status
Off-patent
Clinical Trials
As a well-established vitamin combination, Neuroson typically does not undergo new clinical trials for efficacy, but individual components have extensive trial data.
Lab Monitoring
- Not typically required for routine use. In cases of suspected deficiency, vitamin B levels can be measured.
Doctor Notes
- Emphasize patient compliance for optimal therapeutic outcomes.
- Advise patients on dietary sources of B vitamins.
- Monitor for signs of peripheral neuropathy in patients on high-dose, long-term therapy.
Patient Guidelines
- Take as directed by your physician or pharmacist.
- Do not exceed the recommended dose.
- Store in a cool, dry place away from direct sunlight.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Neuroson is not known to impair the ability to drive or operate machinery.
Lifestyle Advice
- Maintain a balanced diet rich in B vitamins.
- Avoid excessive alcohol consumption, as it can deplete B vitamins.
- Consult a doctor for underlying conditions causing vitamin deficiency.
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