Nevola
Generic Name
Nevoline Hydrochloride
Manufacturer
MediPharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nevola 100 mg tablet | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Nevola 100 mg Tablet is an antidepressant medication used to treat major depressive disorder, anxiety disorders, and panic disorder by affecting certain chemicals in the brain.
Uses & Indications
Dosage
Adults
Initial dose 50 mg once daily, may be increased to 100 mg daily after several weeks. Maximum recommended dose is 200 mg daily.
Elderly
Lower starting doses (e.g., 25 mg) may be considered, with gradual titration based on response and tolerability.
Renal_impairment
No dosage adjustment required for mild to moderate renal impairment. Caution advised in severe impairment.
How to Take
Nevola tablets should be taken orally, once daily, with or without food. It is recommended to take it at the same time each day.
Mechanism of Action
Nevola (Nevoline Hydrochloride) acts by selectively inhibiting the reuptake of serotonin by neurons in the central nervous system. This increases the concentration of serotonin in the synaptic cleft, thereby enhancing serotonergic neurotransmission.
Pharmacokinetics
Onset
Therapeutic effects may take 2-4 weeks to become apparent, with full effect potentially taking longer.
Excretion
Mainly excreted via urine and feces as metabolites.
Half life
Approximately 24-30 hours, allowing for once-daily dosing.
Absorption
Well absorbed orally, peak plasma concentrations typically reached within 4-8 hours. Food may slightly delay absorption but does not significantly alter bioavailability.
Metabolism
Extensively metabolized in the liver, primarily by CYP enzymes, to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Nevoline Hydrochloride or any excipients
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs)
Drug Interactions
MAOIs
Concurrent use is contraindicated due to risk of serotonin syndrome.
NSAIDs
Increased risk of bleeding, especially gastrointestinal.
Warfarin
May enhance the anticoagulant effect of warfarin, requiring careful monitoring of INR.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, nausea, vomiting, tachycardia, tremor, agitation, and dizziness. Management is supportive and symptomatic, focusing on maintaining airway, breathing, and circulation. Activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Small amounts may be excreted in breast milk; caution advised during lactation.
Side Effects
Contraindications
- Hypersensitivity to Nevoline Hydrochloride or any excipients
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs)
Drug Interactions
MAOIs
Concurrent use is contraindicated due to risk of serotonin syndrome.
NSAIDs
Increased risk of bleeding, especially gastrointestinal.
Warfarin
May enhance the anticoagulant effect of warfarin, requiring careful monitoring of INR.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, nausea, vomiting, tachycardia, tremor, agitation, and dizziness. Management is supportive and symptomatic, focusing on maintaining airway, breathing, and circulation. Activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Small amounts may be excreted in breast milk; caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Available in pharmacies and hospitals nationwide
Approval Status
Approved by DGDA
Patent Status
Patented
Clinical Trials
Extensive clinical trials have demonstrated Nevola's efficacy and safety in the treatment of major depressive disorder and anxiety disorders across various populations.
Lab Monitoring
- Liver function tests (periodically)
- Renal function tests (for severe impairment)
Doctor Notes
- Initiate therapy with a low dose and titrate gradually to minimize side effects.
- Educate patients on the delayed onset of action and the importance of continued adherence.
- Monitor for signs of worsening depression, suicidality, and emergent neuropsychiatric symptoms.
Patient Guidelines
- Do not stop taking Nevola abruptly, as this can lead to withdrawal symptoms.
- It may take several weeks for the full therapeutic effects to be observed.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not take a double dose to make up for a missed one.
Driving Precautions
Nevola may cause dizziness or drowsiness. Patients should be cautioned about operating hazardous machinery, including automobiles, until they are reasonably certain that Nevola therapy does not adversely affect their ability to engage in such activities.
Lifestyle Advice
- Avoid alcohol consumption while taking this medication.
- Maintain a healthy diet and regular exercise routine.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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