Nevola
Generic Name
nevola-50-mg-tablet
Manufacturer
Fictional Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nevola 50 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Nevola 50 mg Tablet is a medication used to treat hypertension (high blood pressure) by selectively dilating peripheral blood vessels, which helps to lower blood pressure and reduce the workload on the heart.
Uses & Indications
Dosage
Adults
Initial dose: 50 mg once daily. May be increased to 100 mg once daily if needed, based on clinical response and tolerability.
Elderly
Initial dose: 25 mg once daily, titrate carefully upwards.
Renal_impairment
Initial dose: 25 mg once daily. Max 50 mg once daily for severe impairment (CrCl <30 mL/min).
How to Take
To be taken orally, preferably at the same time each day, with or without food. Swallow the tablet whole with water.
Mechanism of Action
Nevola acts as a selective peripheral vasodilator, directly relaxing the smooth muscles in the walls of blood vessels, particularly arterioles, leading to reduced peripheral vascular resistance and a subsequent decrease in blood pressure.
Pharmacokinetics
Onset
Onset of action within 1-2 hours.
Excretion
Primarily excreted via urine (60%) and feces (40%) as metabolites.
Half life
Elimination half-life of approximately 10-14 hours.
Absorption
Well absorbed orally, with bioavailability around 80-90%.
Metabolism
Extensively metabolized in the liver by cytochrome P450 enzymes (mainly CYP3A4).
Side Effects
Contraindications
- Hypersensitivity to Nevola or any excipients
- Cardiogenic shock
- Unstable angina
- Severe hepatic impairment
Drug Interactions
Diuretics
May potentiate hypotensive effect.
Other Antihypertensives
Additive hypotensive effects.
CYP3A4 Inhibitors (e.g., Ketoconazole)
May increase Nevola plasma levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include severe hypotension, bradycardia, dizziness, and collapse. Management involves supportive care, fluid resuscitation, and vasopressors if needed.
Pregnancy & Lactation
Use in pregnancy only if potential benefit outweighs risk to the fetus (Category C). Not recommended during breastfeeding due to potential excretion into breast milk.
Side Effects
Contraindications
- Hypersensitivity to Nevola or any excipients
- Cardiogenic shock
- Unstable angina
- Severe hepatic impairment
Drug Interactions
Diuretics
May potentiate hypotensive effect.
Other Antihypertensives
Additive hypotensive effects.
CYP3A4 Inhibitors (e.g., Ketoconazole)
May increase Nevola plasma levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include severe hypotension, bradycardia, dizziness, and collapse. Management involves supportive care, fluid resuscitation, and vasopressors if needed.
Pregnancy & Lactation
Use in pregnancy only if potential benefit outweighs risk to the fetus (Category C). Not recommended during breastfeeding due to potential excretion into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Extensive clinical trials (Phase I, II, III) demonstrated significant efficacy in reducing blood pressure in hypertensive patients and a favorable safety profile. Post-marketing surveillance data is ongoing.
Lab Monitoring
- Regular blood pressure monitoring
- Renal function tests (e.g., Creatinine, eGFR)
- Liver function tests (e.g., ALT, AST) annually
Doctor Notes
- Monitor patients for orthostatic hypotension, especially during initial titration.
- Advise patients on lifestyle modifications to enhance therapeutic outcomes.
Patient Guidelines
- Take as directed by your doctor
- Do not stop suddenly without consulting your doctor
- Report any unusual side effects promptly
Missed Dose Advice
If a dose is missed, take it as soon as remembered unless it is almost time for the next dose. Do not double the dose to catch up.
Driving Precautions
May cause dizziness or lightheadedness, especially at the start of treatment or when increasing dose. Avoid driving or operating machinery until you know how Nevola affects you.
Lifestyle Advice
- Maintain a healthy diet low in sodium
- Engage in regular physical activity
- Avoid smoking and limit alcohol intake
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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