Nexcital
Generic Name
Escitalopram
Manufacturer
Local Pharmaceutical Company
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nexcital 10 mg tablet | ৳ 13.00 | ৳ 130.00 |
Description
Overview of the medicine
Nexcital 10 mg Tablet contains Escitalopram, a selective serotonin reuptake inhibitor (SSRI) used to treat major depressive disorder (MDD) and generalized anxiety disorder (GAD). It helps to restore the balance of a natural substance (serotonin) in the brain.
Uses & Indications
Dosage
Adults
Initial dose is 10 mg once daily. May be increased to 20 mg once daily after a minimum of one week, depending on patient response. Max dose 20 mg/day.
Elderly
A starting dose of 5 mg once daily is recommended. Maximum recommended dose is 10 mg once daily.
Renal_impairment
No dosage adjustment is generally needed for mild to moderate renal impairment. Caution is advised in severe impairment due to limited data.
How to Take
Nexcital 10 mg Tablet should be taken orally, once daily, with or without food. It is recommended to take the tablet at the same time each day.
Mechanism of Action
Escitalopram selectively inhibits the reuptake of serotonin (5-HT) into the presynaptic neuron, thereby increasing the concentration of 5-HT in the synaptic cleft. This leads to enhanced serotonergic neurotransmission in the central nervous system.
Pharmacokinetics
Onset
Clinical effects may take 2-4 weeks to become apparent, though some patients may experience benefits earlier.
Excretion
Approximately 8% of the dose is excreted as unchanged escitalopram in urine. Metabolites are excreted via both urine and feces.
Half life
Approximately 27-32 hours, allowing for once-daily dosing.
Absorption
Well absorbed orally, with absolute bioavailability of about 80%. Peak plasma concentrations are reached in approximately 5 hours.
Metabolism
Extensively metabolized in the liver to active and inactive metabolites via CYP3A4, CYP2C19, and CYP2D6 enzymes. The primary active metabolite is S-desmethylcitalopram (S-DCT).
Side Effects
Contraindications
- •Hypersensitivity to escitalopram or citalopram or any component of the formulation.
- •Concomitant use with Monoamine Oxidase Inhibitors (MAOIs), including linezolid and intravenous methylene blue.
- •Concomitant use with pimozide.
- •Patients with congenital long QT syndrome or known prolonged QT interval.
Drug Interactions
MAOIs
Concurrent use with MAOIs can lead to serious, sometimes fatal, reactions including Serotonin Syndrome.
NSAIDs
May increase the risk of gastrointestinal bleeding.
Alcohol
Not recommended due to potential for enhanced CNS depressive effects.
Pimozide
Concomitant use is contraindicated due to increased QT prolongation.
Warfarin and other anticoagulants
Increased risk of bleeding due to potential interference with platelet aggregation.
Serotonergic drugs (e.g., other SSRIs, SNRIs, triptans, tramadol, tryptophan)
Increased risk of Serotonin Syndrome.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include dizziness, tremor, agitation, somnolence, nausea, vomiting, tachycardia, QTc prolongation, and, rarely, seizures or serotonin syndrome. Management is primarily supportive, maintaining a patent airway, and monitoring cardiac and vital signs. Activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Escitalopram is excreted in human breast milk; therefore, caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture when stored under recommended conditions.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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