Take orally with food or milk to enhance absorption and reduce gastrointestinal upset. Shake the suspension well before each use. Use a calibrated measuring device for accurate dosing.

Nitrofurantoin is reduced by bacterial flavoproteins to reactive intermediates that inactivate or damage bacterial ribosomal proteins and other macromolecules (DNA, RNA, cell wall synthesis), leading to inhibition of vital biochemical processes of the bacteria.

• •Known hypersensitivity to nitrofurantoin or any component of the formulation.
• •Anuria, oliguria, or significant impairment of renal function (creatinine clearance <60 mL/min or elevated serum creatinine).
• •History of cholestatic jaundice/hepatic dysfunction associated with nitrofurantoin.
• •Pregnant patients at term (38-42 weeks gestation), during labor and delivery, or when the onset of labor is imminent due to the possibility of hemolytic anemia in the neonate.
• •Infants less than one month of age.
• •Patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency.

Store at controlled room temperature (20-25°C or 68-77°F), away from moisture and light. Do not freeze. Keep out of reach of children.

In case of overdose, supportive care is recommended. Induction of emesis or gastric lavage may be appropriate. Maintain fluid and electrolyte balance. Dialysis is of no value in nitrofurantoin overdose.

Pregnancy Category B. Generally considered safe in early pregnancy but should be avoided at term (38-42 weeks gestation) due to the risk of hemolytic anemia in the neonate. Excreted in breast milk; use with caution in breastfeeding mothers, especially if the infant is <1 month old or has G6PD deficiency.