Nilcid
Generic Name
Esomeprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nilcid 480 mg suspension | ৳ 100.30 | N/A |
Description
Overview of the medicine
Nilcid (Esomeprazole) is a proton pump inhibitor that reduces gastric acid secretion. It is used to treat gastroesophageal reflux disease (GERD), stomach ulcers, and conditions involving excessive stomach acid.
Uses & Indications
Dosage
Adults
For GERD/Erosive Esophagitis: 20-40 mg once daily for 4-8 weeks. For H. pylori eradication: 20 mg twice daily with appropriate antibiotics for 7-14 days. For Zollinger-Ellison syndrome: Initial dose 40 mg twice daily, adjusted as needed.
Elderly
No specific dose adjustment is required for the elderly, but caution is advised in patients with severe hepatic impairment.
Renal_impairment
No dose adjustment is necessary for patients with impaired renal function.
How to Take
Take orally, usually once daily, at least 1 hour before a meal. Swallow capsules whole; do not chew or crush. If difficulty swallowing, capsules may be opened and granules mixed with a small amount of water or soft food.
Mechanism of Action
Esomeprazole is a proton pump inhibitor that specifically inhibits the H+/K+-ATPase enzyme system in the gastric parietal cells. This action reduces both basal and stimulated acid secretion, providing effective relief from acid-related conditions.
Pharmacokinetics
Onset
Onset of acid secretion inhibition occurs within 1 hour.
Excretion
Approximately 80% of metabolites are excreted in the urine and the remainder in the feces.
Half life
Plasma half-life is approximately 1 to 1.5 hours.
Absorption
Rapidly absorbed after oral administration. Bioavailability increases with repeated dosing (approx. 64% after single dose, 89% after repeated doses).
Metabolism
Extensively metabolized in the liver by the cytochrome P450 system (primarily CYP2C19 and CYP3A4).
Side Effects
Contraindications
- Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concurrent use with nelfinavir.
Drug Interactions
Digoxin
Increased digoxin levels.
Warfarin
Increased INR and bleeding risk.
Clopidogrel
Reduced antiplatelet effect of clopidogrel.
Atazanavir/Nelfinavir
Reduced plasma concentrations of these antiretrovirals.
Ketoconazole/Itraconazole
Reduced absorption due to altered gastric pH.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Limited experience with overdose. Symptoms may include drowsiness, tachycardia, nausea, diarrhea, and headache. Treatment is symptomatic and supportive. Esomeprazole is not readily dialyzable.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed and potential benefits outweigh risks. Esomeprazole is excreted in breast milk; caution advised for nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concurrent use with nelfinavir.
Drug Interactions
Digoxin
Increased digoxin levels.
Warfarin
Increased INR and bleeding risk.
Clopidogrel
Reduced antiplatelet effect of clopidogrel.
Atazanavir/Nelfinavir
Reduced plasma concentrations of these antiretrovirals.
Ketoconazole/Itraconazole
Reduced absorption due to altered gastric pH.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Limited experience with overdose. Symptoms may include drowsiness, tachycardia, nausea, diarrhea, and headache. Treatment is symptomatic and supportive. Esomeprazole is not readily dialyzable.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed and potential benefits outweigh risks. Esomeprazole is excreted in breast milk; caution advised for nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies nationwide in Bangladesh
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Off-patent (generic available)
WHO Essential Medicine
YesClinical Trials
Extensively studied in numerous clinical trials demonstrating efficacy and safety for approved indications.
Lab Monitoring
- Consider vitamin B12 levels during long-term therapy (over 3 years) due to potential malabsorption.
- Monitor INR for patients on warfarin.
Doctor Notes
- Consider lowest effective dose for shortest duration. Review necessity of continued PPI therapy periodically.
- Educate patients on potential long-term risks.
Patient Guidelines
- Take as directed by your doctor.
- Do not crush or chew capsules.
- Report any severe or persistent side effects.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Esomeprazole may cause dizziness or visual disturbances in some patients. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Avoid spicy foods, caffeine, and alcohol if they worsen your symptoms.
- Maintain a healthy weight.
- Elevate the head of your bed if you have GERD.
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Global Brand Names
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