Ninacent
Generic Name
Centacin
Manufacturer
Fictional Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ninacent 100 mg capsule | ৳ 235.00 | ৳ 2,350.00 |
Description
Overview of the medicine
Ninacent 100 mg Capsule contains Centacin, a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, reduce inflammation, and lower fever. It is commonly prescribed for conditions like arthritis, muscle pain, menstrual pain, and postoperative pain.
Uses & Indications
Dosage
Adults
The usual recommended dose is 100 mg once or twice daily, taken with food. The maximum daily dose should not exceed 200 mg.
Elderly
No specific dose adjustment is usually required, but caution is advised due to potential increased risk of side effects, especially gastrointestinal and renal.
Renal_impairment
Use with caution in patients with mild to moderate renal impairment. Dosage reduction may be necessary in severe impairment. Not recommended for severe renal failure.
How to Take
Take Ninacent 100 mg Capsule orally with a full glass of water, preferably with or after food, to minimize gastrointestinal discomfort. Do not crush, chew, or break the capsule.
Mechanism of Action
Centacin works by inhibiting the production of prostaglandins, which are chemicals in the body that cause inflammation, pain, and fever. It primarily acts by blocking the cyclooxygenase (COX) enzymes, COX-1 and COX-2, reducing their synthesis.
Pharmacokinetics
Onset
Pain relief typically begins within 30-60 minutes.
Excretion
Excreted mainly through urine (renal excretion) and to a lesser extent via feces.
Half life
Approximately 2-4 hours.
Absorption
Well-absorbed from the gastrointestinal tract after oral administration. Peak plasma concentrations are usually reached within 1-2 hours.
Metabolism
Primarily metabolized in the liver by cytochrome P450 enzymes.
Side Effects
Contraindications
- Hypersensitivity to Centacin or any other NSAIDs (e.g., aspirin, ibuprofen)
- Active peptic ulcer or gastrointestinal bleeding
- Severe heart failure, renal impairment, or hepatic impairment
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
Increased plasma lithium levels, potentially leading to toxicity.
Methotrexate
Increased plasma methotrexate levels and toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Diuretics and ACE inhibitors
Reduced hypotensive effect and increased risk of renal impairment.
Warfarin and other anticoagulants
Increased risk of bleeding.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, lethargy, and gastrointestinal bleeding. Management involves symptomatic and supportive care. Gastric lavage and activated charcoal may be considered if ingested recently.
Pregnancy & Lactation
Pregnancy Category C (first two trimesters), Category D (third trimester). Avoid use in the third trimester due to potential adverse effects on the fetus (premature closure of ductus arteriosus). Use with caution during lactation; small amounts may pass into breast milk.
Side Effects
Contraindications
- Hypersensitivity to Centacin or any other NSAIDs (e.g., aspirin, ibuprofen)
- Active peptic ulcer or gastrointestinal bleeding
- Severe heart failure, renal impairment, or hepatic impairment
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
Increased plasma lithium levels, potentially leading to toxicity.
Methotrexate
Increased plasma methotrexate levels and toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Diuretics and ACE inhibitors
Reduced hypotensive effect and increased risk of renal impairment.
Warfarin and other anticoagulants
Increased risk of bleeding.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, lethargy, and gastrointestinal bleeding. Management involves symptomatic and supportive care. Gastric lavage and activated charcoal may be considered if ingested recently.
Pregnancy & Lactation
Pregnancy Category C (first two trimesters), Category D (third trimester). Avoid use in the third trimester due to potential adverse effects on the fetus (premature closure of ductus arteriosus). Use with caution during lactation; small amounts may pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture, when stored as recommended.
Availability
Available in pharmacies and hospitals nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Patent by manufacturer (fictional)
Clinical Trials
Information regarding specific clinical trials for Centacin is available in scientific literature and regulatory submissions. Studies have demonstrated its efficacy in various pain and inflammatory conditions.
Lab Monitoring
- Complete Blood Count (CBC) for long-term therapy
- Renal function tests (serum creatinine, BUN) periodically
- Liver function tests (ALT, AST) periodically
Doctor Notes
- Prescribe the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
- Monitor patients for signs of gastrointestinal bleeding and renal adverse events, especially in elderly or high-risk patients.
- Assess cardiovascular risk factors before and during NSAID therapy.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Report any unusual stomach pain, black stools, or severe side effects to your doctor immediately.
- Avoid alcohol while taking this medicine.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness or drowsiness. Patients should be cautioned about engaging in activities requiring mental alertness, such as driving or operating machinery, until they know how this medication affects them.
Lifestyle Advice
- Maintain adequate hydration.
- Avoid prolonged exposure to sunlight if skin rash occurs.
- Limit alcohol intake.
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