Nitoxin
Generic Name
Nitroxacin 100 mg/5 ml Suspension
Manufacturer
MediCare Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nitoxin 100 mg suspension | ৳ 36.00 | N/A |
Description
Overview of the medicine
Nitoxin 100 mg Suspension is a broad-spectrum antibiotic used for the treatment of various bacterial infections in children.
Uses & Indications
Dosage
Adults
Primarily for pediatric use. For children (1-5 years): 5 ml (100 mg) twice daily. Dosage for older children/adults typically requires higher strength formulations.
Elderly
Dosage adjustments may be required based on renal function and overall health status.
Renal_impairment
Dosage adjustment is necessary in patients with renal impairment; consult physician for specific recommendations.
How to Take
Shake the bottle well before each use. Administer orally using the provided calibrated measuring spoon or cup. Can be taken with or without food. Complete the full prescribed course of treatment.
Mechanism of Action
Nitroxacin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial lysis and death.
Pharmacokinetics
Onset
1-2 hours
Excretion
Primarily renal (glomerular filtration and tubular secretion).
Half life
1.5-2.5 hours
Absorption
Rapidly absorbed from the gastrointestinal tract after oral administration. Peak plasma concentrations reached within 2-4 hours.
Metabolism
Minimal hepatic metabolism; primarily excreted unchanged.
Side Effects
Contraindications
- Known hypersensitivity to nitroxacin, other cephalosporins, or any component of the formulation.
- History of severe hypersensitivity reaction to penicillin (due to potential for cross-reactivity).
Drug Interactions
Probenecid
Increases plasma concentrations and prolongs the half-life of nitroxacin by decreasing renal tubular secretion.
Oral anticoagulants
May increase the anticoagulant effect by interfering with vitamin K synthesis or displacement from plasma protein binding.
Antacids containing aluminum or magnesium
May decrease the absorption of nitroxacin if taken simultaneously.
Storage
Store below 30°C in a dry place, protected from direct sunlight and moisture. Keep out of reach of children. Do not freeze the reconstituted suspension.
Overdose
Symptoms of overdose may include nausea, vomiting, diarrhea, abdominal discomfort, and rarely, central nervous system excitability leading to convulsions. Treatment is symptomatic and supportive. Gastric lavage may be considered in recent ingestions.
Pregnancy & Lactation
Pregnancy Category B. Animal reproduction studies have shown no risk to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Nitroxacin is excreted in breast milk in small amounts; use with caution during lactation.
Side Effects
Contraindications
- Known hypersensitivity to nitroxacin, other cephalosporins, or any component of the formulation.
- History of severe hypersensitivity reaction to penicillin (due to potential for cross-reactivity).
Drug Interactions
Probenecid
Increases plasma concentrations and prolongs the half-life of nitroxacin by decreasing renal tubular secretion.
Oral anticoagulants
May increase the anticoagulant effect by interfering with vitamin K synthesis or displacement from plasma protein binding.
Antacids containing aluminum or magnesium
May decrease the absorption of nitroxacin if taken simultaneously.
Storage
Store below 30°C in a dry place, protected from direct sunlight and moisture. Keep out of reach of children. Do not freeze the reconstituted suspension.
Overdose
Symptoms of overdose may include nausea, vomiting, diarrhea, abdominal discomfort, and rarely, central nervous system excitability leading to convulsions. Treatment is symptomatic and supportive. Gastric lavage may be considered in recent ingestions.
Pregnancy & Lactation
Pregnancy Category B. Animal reproduction studies have shown no risk to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Nitroxacin is excreted in breast milk in small amounts; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months (unopened bottle). After reconstitution, the suspension is stable for 7 days when stored at room temperature.
Availability
Pharmacies and Hospitals
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive Phase III clinical trials demonstrated the efficacy and safety of nitroxacin in the treatment of various pediatric bacterial infections, showing comparable outcomes to established cephalosporins.
Lab Monitoring
- Renal function tests (for prolonged therapy or in patients with pre-existing renal impairment)
- Complete Blood Count (for prolonged therapy)
- Liver function tests (if clinically indicated)
Doctor Notes
- Emphasize the importance of completing the full antibiotic course to prevent bacterial resistance and recurrence of infection.
- Advise parents on proper measurement and administration techniques for oral suspension to ensure accurate dosing.
- Monitor for signs of allergic reactions, especially in patients with a history of penicillin allergy, due to potential cross-reactivity.
- Educate about potential side effects like diarrhea and when to seek medical attention.
Patient Guidelines
- It is crucial to complete the entire course of treatment as prescribed by your doctor, even if symptoms improve.
- Do not stop taking this medicine early, as it may lead to recurrence of infection and development of antibiotic resistance.
- Shake the bottle well before each administration to ensure uniform dosing.
- Use the provided measuring device to ensure accurate dosage.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Nitoxin Suspension may cause dizziness or lightheadedness in some individuals. If you experience these symptoms, avoid driving or operating machinery until you are sure you can perform such activities safely.
Lifestyle Advice
- Maintain adequate hydration by drinking plenty of fluids.
- Practice good hygiene to prevent the spread of infection to others.
- Follow a balanced diet to support recovery.
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