Nizox
Generic Name
Nitazoxanide
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nizox 500 mg tablet | ৳ 10.03 | ৳ 40.12 |
Description
Overview of the medicine
Nizox 500 mg tablet contains Nitazoxanide, an antiprotozoal agent used to treat various parasitic infections, including cryptosporidiosis and giardiasis.
Uses & Indications
Dosage
Adults
500 mg orally every 12 hours for 3 days, taken with food.
Elderly
No specific dose adjustment is generally required for elderly patients; use with caution.
Renal_impairment
No specific dose adjustment recommendations available for renal impairment; caution advised due to limited data.
How to Take
Take Nizox 500 mg tablet orally, with food, to enhance absorption and reduce gastrointestinal upset. Complete the full course of treatment.
Mechanism of Action
Nitazoxanide interferes with the pyruvate ferredoxin oxidoreductase (PFOR) enzyme-dependent electron transfer reaction, which is essential for anaerobic energy metabolism in certain parasites.
Pharmacokinetics
Onset
Clinical effects may be observed within 1-2 days of treatment initiation.
Excretion
Primarily excreted in feces (approximately 60%) as tizoxanide and tizoxanide glucuronide, and to a lesser extent in urine (less than 1%) as tizoxanide.
Half life
Plasma half-life of tizoxanide is approximately 1.5 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract and rapidly hydrolyzed to its active metabolite, tizoxanide, and tizoxanide glucuronide.
Metabolism
Extensively metabolized by hydrolysis to tizoxanide and tizoxanide glucuronide.
Side Effects
Contraindications
- Hypersensitivity to nitazoxanide or any component of the formulation.
- Patients with severe hepatic impairment.
Drug Interactions
Warfarin
Nitazoxanide may displace warfarin from plasma protein binding sites, leading to an increased prothrombin time (INR). Monitor INR closely.
Highly protein-bound drugs
Caution should be exercised when nitazoxanide is co-administered with other highly protein-bound drugs with narrow therapeutic indices, as competition for binding sites may occur.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, supportive care and symptomatic treatment are recommended. There is no specific antidote for nitazoxanide.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of impaired fertility or harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. It is unknown whether nitazoxanide is excreted in human milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to nitazoxanide or any component of the formulation.
- Patients with severe hepatic impairment.
Drug Interactions
Warfarin
Nitazoxanide may displace warfarin from plasma protein binding sites, leading to an increased prothrombin time (INR). Monitor INR closely.
Highly protein-bound drugs
Caution should be exercised when nitazoxanide is co-administered with other highly protein-bound drugs with narrow therapeutic indices, as competition for binding sites may occur.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, supportive care and symptomatic treatment are recommended. There is no specific antidote for nitazoxanide.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of impaired fertility or harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. It is unknown whether nitazoxanide is excreted in human milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 to 3 years from manufacturing date, check expiry date on packaging.
Availability
Pharmacies, Hospitals
Approval Status
FDA Approved
Patent Status
Generic available
Clinical Trials
Nitazoxanide has been studied in numerous clinical trials for its efficacy in treating various parasitic infections, including those caused by Cryptosporidium parvum, Giardia lamblia, and Entamoeba histolytica.
Lab Monitoring
- Liver function tests (LFTs) may be considered in patients with pre-existing hepatic impairment or prolonged use.
- Routine monitoring is generally not required.
Doctor Notes
- Advise patients to complete the full 3-day course for optimal efficacy.
- Inform patients about the importance of taking the medication with food.
- Consider INR monitoring if co-administering with warfarin.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Complete the entire course of treatment, even if you feel better.
- Take with food to improve absorption and reduce stomach upset.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Nitazoxanide is generally not expected to impair the ability to drive or operate machinery. However, if you experience dizziness or fatigue, avoid such activities.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Stay hydrated, especially if experiencing diarrhea.
- Avoid sharing personal items.
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