No-Spa
Generic Name
Drotaverine Hydrochloride
Manufacturer
Sanofi
Country
Various (originates from Hungary)
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| no spa 40 mg injection | ৳ 7.98 | N/A |
Description
Overview of the medicine
No-Spa 40 mg injection contains Drotaverine, a smooth muscle relaxant used to relieve spasms of the gastrointestinal, genitourinary, and biliary tracts.
Uses & Indications
Dosage
Adults
40-80 mg (1-2 ampoules) intramuscularly or intravenously, 1-3 times daily. Maximum daily dose is 240 mg.
Elderly
No specific dose adjustment is usually required, but caution is advised in elderly patients, especially those with pre-existing cardiac conditions.
Renal_impairment
No dose adjustment is usually required for mild to moderate renal impairment. Use with caution in severe renal insufficiency.
How to Take
No-Spa 40 mg injection should be administered intramuscularly or slowly intravenously by a healthcare professional. For intravenous administration, it may be diluted with 50-100 mL of 0.9% sodium chloride solution.
Mechanism of Action
Drotaverine inhibits phosphodiesterase (PDE) IV, an enzyme specific to smooth muscle cells, leading to an increase in intracellular cyclic adenosine monophosphate (cAMP) and subsequent relaxation of smooth muscles.
Pharmacokinetics
Onset
Within 2-4 minutes intravenously, 10-15 minutes intramuscularly.
Excretion
Primarily excreted via urine (approx. 50%) and feces (approx. 30%) as metabolites.
Half life
Approximately 9-10 hours.
Absorption
Rapid and complete absorption after intramuscular (IM) administration.
Metabolism
Extensively metabolized in the liver via O-demethylation.
Side Effects
Contraindications
- Hypersensitivity to drotaverine or any excipients
- Severe hepatic, renal, or cardiac insufficiency (severe heart failure)
- Hypotension
- AV block II-III
- Children under 1 year of age
Drug Interactions
Levodopa
May decrease the antiparkinsonian effect of levodopa due to its ability to relax smooth muscle and potentially reduce gastric emptying, affecting levodopa absorption.
Papaverine and other smooth muscle relaxants
Increased antispasmodic effect when co-administered.
Storage
Store below 30°C in a dry place, protected from light. Do not freeze.
Overdose
Overdose may cause cardiac arrhythmias and severe hypotension. Management includes supportive and symptomatic treatment, including monitoring vital signs and managing hypotension.
Pregnancy & Lactation
Use with caution during pregnancy only if clearly needed and the potential benefits outweigh the risks. Avoid during lactation as limited data are available on its excretion into breast milk.
Side Effects
Contraindications
- Hypersensitivity to drotaverine or any excipients
- Severe hepatic, renal, or cardiac insufficiency (severe heart failure)
- Hypotension
- AV block II-III
- Children under 1 year of age
Drug Interactions
Levodopa
May decrease the antiparkinsonian effect of levodopa due to its ability to relax smooth muscle and potentially reduce gastric emptying, affecting levodopa absorption.
Papaverine and other smooth muscle relaxants
Increased antispasmodic effect when co-administered.
Storage
Store below 30°C in a dry place, protected from light. Do not freeze.
Overdose
Overdose may cause cardiac arrhythmias and severe hypotension. Management includes supportive and symptomatic treatment, including monitoring vital signs and managing hypotension.
Pregnancy & Lactation
Use with caution during pregnancy only if clearly needed and the potential benefits outweigh the risks. Avoid during lactation as limited data are available on its excretion into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 3 years from the date of manufacture, refer to package for exact date.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Off-patent
Clinical Trials
Drotaverine has undergone numerous clinical trials demonstrating its efficacy and safety in relieving various smooth muscle spasms.
Lab Monitoring
- No routine lab monitoring is generally required for drotaverine.
Doctor Notes
- Monitor patient for hypotension, especially during and after intravenous administration.
- Exercise caution in patients with hepatic or renal impairment, though dose adjustment is not always necessary.
- Advise patients about potential dizziness and its implications for driving or operating machinery.
Patient Guidelines
- Do not self-administer this injection. It should be given by a healthcare professional.
- Inform your doctor about all your medical conditions and other medications you are taking.
- Report any unusual or severe side effects to your doctor immediately.
Missed Dose Advice
If a dose is missed, administer the next dose as scheduled. Do not double the dose to compensate for a missed one.
Driving Precautions
No-Spa injection may cause dizziness, especially after intravenous administration. Patients should be cautioned against driving or operating machinery until they are certain that their ability to perform such activities is not impaired.
Lifestyle Advice
- Maintain a healthy diet and stay hydrated.
- Avoid alcohol consumption while on medication if experiencing dizziness.
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Global Brand Names
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