No-Spa
Generic Name
Drotaverine Hydrochloride
Manufacturer
Sanofi
Country
France (original manufacturer)
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| no spa 40 mg tablet | ৳ 1.82 | ৳ 18.20 |
Description
Overview of the medicine
Drotaverine is an antispasmodic drug primarily used to treat functional disorders and pain caused by smooth muscle spasms. It is effective in relieving various types of abdominal pain and cramps.
Uses & Indications
Dosage
Adults
Adults: 40-80 mg, 2-3 times daily. Maximum daily dose is 240 mg.
Elderly
Elderly: No specific dose adjustment generally required, but caution with liver/kidney impairment.
Renal_impairment
Renal impairment: Use with caution, dose adjustment may be necessary in severe cases.
How to Take
Oral administration. Tablets should be swallowed whole with water, with or without food.
Mechanism of Action
Drotaverine acts by inhibiting phosphodiesterase-4 (PDE4), an enzyme specific to smooth muscle cells. This leads to an increase in intracellular cyclic AMP (cAMP) levels, resulting in the relaxation of smooth muscles and alleviation of spasms.
Pharmacokinetics
Onset
15-20 minutes orally, faster parenterally.
Excretion
Primarily excreted in urine (about 50%) and feces (about 30%) as metabolites.
Half life
Approximately 9-14 hours.
Absorption
Rapid and complete absorption after oral administration. Peak plasma concentration is reached within 45-60 minutes.
Metabolism
Extensive first-pass metabolism in the liver. Metabolized by O-demethylation.
Side Effects
Contraindications
- Hypersensitivity to Drotaverine or any excipients
- Severe hepatic, renal or cardiac insufficiency
- Children under 6 years of age
- Lactation
- AV block grade II and III
Drug Interactions
Levodopa
Reduces the anti-parkinsonian effect of levodopa, potentially leading to increased rigidity and tremor.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms include cardiac rhythm and conduction disorders, severe hypotension, and respiratory depression. Management involves symptomatic and supportive treatment, including gastric lavage.
Pregnancy & Lactation
Pregnancy Category B. Use with caution during pregnancy if clearly needed. Not recommended during lactation.
Side Effects
Contraindications
- Hypersensitivity to Drotaverine or any excipients
- Severe hepatic, renal or cardiac insufficiency
- Children under 6 years of age
- Lactation
- AV block grade II and III
Drug Interactions
Levodopa
Reduces the anti-parkinsonian effect of levodopa, potentially leading to increased rigidity and tremor.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms include cardiac rhythm and conduction disorders, severe hypotension, and respiratory depression. Management involves symptomatic and supportive treatment, including gastric lavage.
Pregnancy & Lactation
Pregnancy Category B. Use with caution during pregnancy if clearly needed. Not recommended during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date
Availability
Pharmacies and hospitals
Approval Status
Approved globally for symptomatic relief of smooth muscle spasm
Patent Status
Off-patent, widely available as generic
Clinical Trials
Extensive clinical trials have established Drotaverine's efficacy and safety in various spasmodic conditions over decades of use.
Lab Monitoring
- No specific routine lab monitoring required.
Doctor Notes
- Advise patients on potential dizziness and its implications for driving.
- Caution with patients having severe cardiac, renal, or hepatic impairment.
- Monitor for signs of hypersensitivity reactions.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
- Do not stop taking the medicine without consulting your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness, especially at the start of treatment. Patients should be warned not to drive or operate machinery until they are aware of how Drotaverine affects them.
Lifestyle Advice
- Avoid alcohol consumption if it exacerbates gastrointestinal discomfort.
- Maintain a balanced diet and adequate hydration to support gastrointestinal health.
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