Nocpres
Generic Name
nocpres-100-mcg-tablet
Manufacturer
PharmaCorp Global
Country
USA
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nocpres 100 mcg tablet | ৳ 30.00 | ৳ 300.00 |
Description
Overview of the medicine
Nocpres 100 mcg tablet is used for the management of chronic neuropathic pain. It works by modulating specific neurotransmitter release in the central nervous system.
Uses & Indications
Dosage
Adults
Initial dose 100 mcg once daily, titrated up to 300-600 mcg daily in divided doses based on response and tolerability. Max daily dose: 900 mcg.
Elderly
Start with lower doses (e.g., 50 mcg once daily) and titrate slowly due to potential for reduced renal clearance.
Renal_impairment
Dosage adjustment required. For CrCl 30-60 mL/min, reduce dose by 25-50%. For CrCl <30 mL/min, reduce by 50-75%.
How to Take
Take orally with or without food. Swallow the tablet whole; do not crush or chew.
Mechanism of Action
Nocpres binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, reducing the release of excitatory neurotransmitters such as glutamate, substance P, and norepinephrine. This action contributes to its analgesic and anxiolytic effects.
Pharmacokinetics
Onset
Within 2-3 days for therapeutic effect
Excretion
Renal excretion (primarily unchanged drug)
Half life
Approximately 6-8 hours
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations reached within 1-2 hours. Bioavailability is high and not significantly affected by food.
Metabolism
Minimal hepatic metabolism; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to Nocpres or any components of the formulation
- Acute pancreatitis
Drug Interactions
Alcohol
Enhances CNS depressant effects. Avoid concomitant use.
Antacids
May decrease the absorption of Nocpres. Separate administration by at least 2 hours.
CNS Depressants (e.g., opioids, benzodiazepines)
Increased risk of sedation and respiratory depression. Use with caution.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms may include somnolence, dizziness, ataxia, and lethargy. Treatment is supportive; hemodialysis may be effective in severe cases.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Excreted in breast milk; caution advised during lactation.
Side Effects
Contraindications
- Hypersensitivity to Nocpres or any components of the formulation
- Acute pancreatitis
Drug Interactions
Alcohol
Enhances CNS depressant effects. Avoid concomitant use.
Antacids
May decrease the absorption of Nocpres. Separate administration by at least 2 hours.
CNS Depressants (e.g., opioids, benzodiazepines)
Increased risk of sedation and respiratory depression. Use with caution.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms may include somnolence, dizziness, ataxia, and lethargy. Treatment is supportive; hemodialysis may be effective in severe cases.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Excreted in breast milk; caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Under patent protection
Clinical Trials
Phase III clinical trials demonstrated significant reduction in pain scores compared to placebo in patients with diabetic neuropathy. Studies are ongoing for postherpetic neuralgia.
Lab Monitoring
- Renal function tests (e.g., CrCl) if impairment is suspected
- Monitor for changes in mood or behavior, especially during initial therapy or dose changes.
Doctor Notes
- Emphasize slow titration to minimize side effects.
- Counsel patients on potential CNS depression and interaction with alcohol.
- Assess renal function before initiating therapy and adjust dose as needed.
Patient Guidelines
- Do not stop taking Nocpres abruptly, as this may lead to withdrawal symptoms.
- Report any unusual changes in mood or behavior to your doctor.
- Avoid driving or operating heavy machinery until you know how Nocpres affects you.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Nocpres may cause dizziness, somnolence, and blurred vision, which can impair your ability to drive or operate machinery. Exercise caution.
Lifestyle Advice
- Maintain a healthy diet and regular exercise to support overall well-being.
- Avoid alcohol consumption while on Nocpres due to increased CNS depression risk.
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