Nocpres
Generic Name
Desmopressin
Manufacturer
Hypothetical Pharma Co.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nocpres 200 mcg tablet | ৳ 45.00 | ৳ 450.00 |
Description
Overview of the medicine
Nocpres 200 mcg Tablet contains Desmopressin, a synthetic analogue of the natural posterior pituitary hormone, vasopressin. It is used to treat conditions involving excessive urine production, such as nocturnal enuresis (bedwetting), central diabetes insipidus, and nocturnal polyuria.
Uses & Indications
Dosage
Adults
For nocturnal polyuria, initially 200 mcg at bedtime, dose may be increased to 400 mcg if needed. For diabetes insipidus, individualize dosage, typically 100-200 mcg 1-3 times daily.
Elderly
Lower starting dose and careful monitoring for hyponatremia. Not recommended for patients over 65 years with nocturnal polyuria.
Renal_impairment
Use with caution. Not recommended in severe renal impairment (CrCl < 50 mL/min).
How to Take
Take the tablet sublingually (under the tongue) without water, allowing it to dissolve completely. Do not chew or swallow the tablet whole. Administer at bedtime for nocturnal indications.
Mechanism of Action
Desmopressin acts as a selective agonist for V2 vasopressin receptors, primarily in the renal collecting ducts. This increases the reabsorption of water, leading to a decrease in urine output and an increase in urine osmolality, thus concentrating the urine.
Pharmacokinetics
Onset
Antidiuretic effect usually starts within 1 hour.
Excretion
Excreted primarily via the kidneys (renal excretion) in unchanged form.
Half life
The elimination half-life is approximately 2.5 to 3.5 hours.
Absorption
Oral bioavailability of desmopressin is low (0.08-0.16% for tablets), but sublingual absorption is better for the higher potency formulation. Peak plasma concentrations are reached within 0.5 to 2 hours.
Metabolism
Minimal hepatic metabolism. Primarily degraded by peptidases.
Side Effects
Contraindications
- Hypersensitivity to desmopressin or any excipients
- Congenital or psychogenic polydipsia
- Known or suspected cardiac insufficiency
- Hyponatremia
- Moderate to severe renal impairment (CrCl < 50 mL/min)
Drug Interactions
Loop Diuretics, NSAIDs
Increased risk of hyponatremia and fluid retention.
Tricyclic Antidepressants, SSRIs
May increase the risk of hyponatremia.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include water retention and hyponatremia (headache, nausea, confusion, seizures). Management involves fluid restriction, discontinuing the drug, and correcting hyponatremia.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Desmopressin is excreted in breast milk in very small amounts; caution advised during lactation.
Side Effects
Contraindications
- Hypersensitivity to desmopressin or any excipients
- Congenital or psychogenic polydipsia
- Known or suspected cardiac insufficiency
- Hyponatremia
- Moderate to severe renal impairment (CrCl < 50 mL/min)
Drug Interactions
Loop Diuretics, NSAIDs
Increased risk of hyponatremia and fluid retention.
Tricyclic Antidepressants, SSRIs
May increase the risk of hyponatremia.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include water retention and hyponatremia (headache, nausea, confusion, seizures). Management involves fluid restriction, discontinuing the drug, and correcting hyponatremia.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Desmopressin is excreted in breast milk in very small amounts; caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved (for Desmopressin)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of desmopressin in its approved indications, focusing on reduction of urine output and improvement in quality of life.
Lab Monitoring
- Serum sodium levels (especially at initiation and during dose adjustments)
- Fluid balance monitoring
- Renal function tests
Doctor Notes
- Emphasize strict adherence to fluid restriction to minimize hyponatremia risk.
- Monitor serum sodium levels closely, especially in elderly and pediatric patients.
- Educate patients on symptoms of hyponatremia and when to seek immediate medical attention.
Patient Guidelines
- Adhere strictly to fluid restriction, especially 1 hour before and 8 hours after taking the tablet.
- Do not take extra fluid if you feel thirsty; consult your doctor.
- Report any symptoms of hyponatremia (headache, nausea, confusion) to your doctor immediately.
Missed Dose Advice
If you miss a dose, skip the missed dose and continue with your next scheduled dose at the usual time. Do not double the dose to catch up.
Driving Precautions
Generally, it does not affect the ability to drive or operate machinery. However, if side effects like dizziness occur, avoid such activities.
Lifestyle Advice
- Limit fluid intake before bedtime, especially for nocturnal polyuria. Avoid excessive alcohol consumption.
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