Nohist
Generic Name
Fexofenadine
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nohist 10 mg tablet | ৳ 3.00 | ৳ 30.00 |
Description
Overview of the medicine
Nohist (Fexofenadine) is a non-sedating antihistamine used to relieve symptoms of seasonal allergic rhinitis and chronic idiopathic urticaria.
Uses & Indications
Dosage
Adults
For seasonal allergic rhinitis: 60 mg twice daily or 120 mg/180 mg once daily. For chronic idiopathic urticaria: 180 mg once daily.
Elderly
No specific dose adjustment is generally required, but caution is advised in elderly patients with impaired renal function.
Renal_impairment
For patients with impaired renal function, a starting dose of 60 mg once daily is recommended.
How to Take
Take orally with water, preferably before a meal. Do not take with fruit juices.
Mechanism of Action
Fexofenadine is a selective peripheral H1-receptor antagonist. It inhibits histamine release and reduces allergic reactions.
Pharmacokinetics
Onset
Onset of action is approximately 1 hour.
Excretion
Primarily excreted unchanged in the faeces (approximately 80%) and urine (approximately 11%).
Half life
The elimination half-life is approximately 11-15 hours.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations reached in approximately 2-3 hours.
Metabolism
Undergoes minimal hepatic metabolism (less than 5%).
Side Effects
Contraindications
- Hypersensitivity to Fexofenadine or any excipients in the formulation.
Drug Interactions
Erythromycin
May increase fexofenadine plasma levels, although clinical significance is minimal.
Ketoconazole
May increase fexofenadine plasma levels, although clinical significance is minimal.
Antacids (containing aluminum and magnesium)
May decrease the absorption of fexofenadine. Separate administration by approximately 2 hours.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include dizziness, drowsiness, and dry mouth. Management should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether Fexofenadine is excreted in human milk, so caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to Fexofenadine or any excipients in the formulation.
Drug Interactions
Erythromycin
May increase fexofenadine plasma levels, although clinical significance is minimal.
Ketoconazole
May increase fexofenadine plasma levels, although clinical significance is minimal.
Antacids (containing aluminum and magnesium)
May decrease the absorption of fexofenadine. Separate administration by approximately 2 hours.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include dizziness, drowsiness, and dry mouth. Management should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether Fexofenadine is excreted in human milk, so caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months (2 years)
Availability
Available in pharmacies and hospitals
Approval Status
Approved
Patent Status
Off-patent (Generic available)
Clinical Trials
Fexofenadine has undergone extensive clinical trials demonstrating its efficacy and safety for the treatment of allergic rhinitis and chronic idiopathic urticaria.
Lab Monitoring
- No specific laboratory monitoring is generally required.
Doctor Notes
- Advise patients to avoid taking Nohist with fruit juices.
- Review concomitant medications to avoid potential interactions with antacids.
- Caution is advised in patients with renal impairment, consider dose adjustment.
- Educate patients on proper administration and potential side effects.
Patient Guidelines
- Take as directed by your doctor.
- Avoid taking with fruit juices.
- Inform your doctor about all other medications you are taking.
- Do not exceed the recommended dose.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Although Nohist is generally non-sedating, individual responses may vary. Observe your reaction before driving or operating machinery.
Lifestyle Advice
- Identify and avoid known allergens (e.g., pollen, dust mites, pet dander) to minimize allergic reactions.
- Maintain a healthy lifestyle with adequate sleep and stress management.
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