Norgest
Generic Name
Norgestrel
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| norgest 003 mg tablet | ৳ 19.95 | N/A |
Description
Overview of the medicine
Norgestrel is a synthetic progestogen used primarily in hormonal contraceptives, often as a component of combined oral contraceptives or as a progestin-only pill. It prevents pregnancy by suppressing ovulation, thickening cervical mucus, and altering the uterine lining.
Uses & Indications
Dosage
Adults
0.075 mg daily, taken at the same time each day, continuously.
Elderly
Not typically indicated for elderly women due to post-menopause.
Renal_impairment
No dose adjustment generally required, but caution is advised.
How to Take
Take one tablet orally at the same time every day, without interruption, even during menstruation.
Mechanism of Action
Norgestrel acts by binding to progesterone receptors, mimicking the effects of natural progesterone. It primarily inhibits gonadotropin secretion, suppressing ovulation. It also causes thickening of cervical mucus, impeding sperm penetration, and endometrial thinning, making it less receptive to implantation.
Pharmacokinetics
Onset
Contraceptive effects begin after several days of consistent use.
Excretion
Excreted via urine and feces as metabolites.
Half life
Approximately 11-45 hours (depending on enantiomer).
Absorption
Rapidly absorbed from the gastrointestinal tract.
Metabolism
Primarily hepatic, extensively metabolized.
Side Effects
Contraindications
- •Known or suspected pregnancy
- •Undiagnosed abnormal genital bleeding
- •Breast cancer or other progestin-sensitive cancer
- •Severe arterial disease
- •Liver adenoma or carcinoma
- •History of cholestatic jaundice of pregnancy
Drug Interactions
Griseofulvin
May reduce contraceptive effectiveness.
St. John's Wort
May reduce contraceptive effectiveness.
Enzyme inducers (e.g., Rifampicin, Phenytoin, Carbamazepine)
May reduce contraceptive effectiveness.
Storage
Store at room temperature, away from moisture and direct light. Keep out of reach of children.
Overdose
Overdose may cause nausea, vomiting, and withdrawal bleeding in females. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Contraindicated during pregnancy. Can be used during lactation; small amounts pass into breast milk but are generally considered safe for the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years (refer to product label)
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
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