Norglic
Generic Name
Norglic
Manufacturer
Local Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| norglic 80 mg tablet | ৳ 6.00 | N/A |
Description
Overview of the medicine
Norglic is a synthetic progestogen used primarily as an oral contraceptive. It works by preventing ovulation and altering the uterine lining and cervical mucus to make conception difficult.
Uses & Indications
Dosage
Adults
For contraception: 0.25 mg once daily, preferably at the same time each day, starting on the first day of menstruation.
Elderly
Not indicated for post-menopausal women; caution with other conditions.
Renal_impairment
No specific dose adjustment required, but use with caution and monitor.
How to Take
Take orally with water, usually at the same time each day without interruption, even during menstruation.
Mechanism of Action
Norglic (Norgestrel) acts by inhibiting the secretion of gonadotropins, thus preventing ovulation. It also thickens the cervical mucus to impede sperm penetration and causes endometrial changes that inhibit implantation.
Pharmacokinetics
Onset
Contraceptive effect begins after consistent use as directed.
Excretion
Excreted primarily via urine (40-67%) and feces (30-52%) as metabolites.
Half life
The plasma elimination half-life is approximately 11-45 hours.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations reached within 1-2 hours.
Metabolism
Extensively metabolized in the liver via hydroxylation and reduction, followed by conjugation.
Side Effects
Contraindications
- Known or suspected pregnancy
- Undiagnosed abnormal genital bleeding
- History of breast cancer or other estrogen/progestogen-dependent neoplasia
- Active liver disease or history of cholestatic jaundice
- Thromboembolic disorders (current or history)
Drug Interactions
Grapefruit juice
May increase plasma levels of Norglic.
Antifungal agents (e.g., Ketoconazole)
May increase Norglic plasma concentrations.
Enzyme inducers (e.g., Rifampicin, Carbamazepine)
May decrease Norglic's effectiveness by increasing its metabolism.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Overdose may cause nausea, vomiting, and withdrawal bleeding. Treatment is symptomatic and supportive; no specific antidote exists.
Pregnancy & Lactation
Norglic is contraindicated during pregnancy. Small amounts are excreted in breast milk, generally considered compatible with breastfeeding, but caution is advised.
Side Effects
Contraindications
- Known or suspected pregnancy
- Undiagnosed abnormal genital bleeding
- History of breast cancer or other estrogen/progestogen-dependent neoplasia
- Active liver disease or history of cholestatic jaundice
- Thromboembolic disorders (current or history)
Drug Interactions
Grapefruit juice
May increase plasma levels of Norglic.
Antifungal agents (e.g., Ketoconazole)
May increase Norglic plasma concentrations.
Enzyme inducers (e.g., Rifampicin, Carbamazepine)
May decrease Norglic's effectiveness by increasing its metabolism.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Overdose may cause nausea, vomiting, and withdrawal bleeding. Treatment is symptomatic and supportive; no specific antidote exists.
Pregnancy & Lactation
Norglic is contraindicated during pregnancy. Small amounts are excreted in breast milk, generally considered compatible with breastfeeding, but caution is advised.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent expired
WHO Essential Medicine
YesClinical Trials
Norglic, as Norgestrel, has been extensively studied in numerous clinical trials establishing its efficacy and safety as an oral contraceptive and for other indications.
Lab Monitoring
- Regular blood pressure checks
- Lipid profile (periodically)
- Liver function tests (if symptoms arise)
Doctor Notes
- Emphasize strict adherence to dosage schedule for optimal contraceptive efficacy.
- Counsel patients on potential non-contraceptive benefits and risks.
- Assess patient's medical history for contraindications before prescribing.
Patient Guidelines
- Take the tablet at the same time every day.
- Do not smoke, especially if over 35 years old.
- Report any unusual bleeding or severe side effects to your doctor.
Missed Dose Advice
If one tablet is missed, take it as soon as remembered. If more than 12 hours late, take the missed tablet and use a backup contraceptive method for 7 days.
Driving Precautions
Norglic is generally not expected to affect the ability to drive or operate machinery. However, if side effects like dizziness occur, avoid such activities.
Lifestyle Advice
- Maintain a healthy diet and regular exercise.
- Attend regular medical check-ups.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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