Novetor
Generic Name
Olmesartan Medoxomil
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| novetor 200 mg tablet | ৳ 6.00 | ৳ 60.00 |
| novetor 400 mg tablet | ৳ 9.00 | ৳ 90.00 |
Description
Overview of the medicine
Novetor (Olmesartan Medoxomil) is an angiotensin II receptor blocker (ARB) used to treat high blood pressure (hypertension) in adults and children 6 years and older. It helps to lower blood pressure, which can reduce the risk of strokes and heart attacks.
Uses & Indications
Dosage
Adults
Initial dose 20 mg once daily. May be increased to 40 mg once daily if needed. Maximum recommended dose is 40 mg once daily.
Elderly
No initial dosage adjustment is typically required, but monitoring of renal function is advised.
Renal_impairment
Initial dose 10 mg once daily for moderate to severe renal impairment. Careful monitoring is necessary.
How to Take
Novetor tablets can be taken orally once daily with or without food.
Mechanism of Action
Olmesartan Medoxomil is a selective AT1 subtype angiotensin II receptor antagonist. It blocks the vasoconstricting and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, including vascular smooth muscle and the adrenal gland. Its action is independent of the pathway for angiotensin II synthesis.
Pharmacokinetics
Onset
Antihypertensive effect generally evident within 2 weeks, maximal effect achieved within 8 weeks.
Excretion
Approximately 35-50% excreted in urine and the remainder in feces via bile.
Half life
Approximately 13 hours.
Absorption
Rapidly and completely absorbed from the GI tract after oral administration, bioavailability is approximately 26%. Peak plasma concentrations reached within 1-2 hours.
Metabolism
Not extensively metabolized in the liver. Medoxomil group is hydrolyzed to the active olmesartan.
Side Effects
Contraindications
- Pregnancy (second and third trimesters)
- Biliary obstruction
- Concomitant use with aliskiren in patients with diabetes mellitus or renal impairment (GFR <60 ml/min/1.73 m²)
- Hypersensitivity to Olmesartan Medoxomil or any component of the formulation
Drug Interactions
NSAIDs
Reduced antihypertensive effect and increased risk of renal impairment, especially in elderly or dehydrated patients.
Lithium
Increased serum lithium concentrations and toxicity. Monitor lithium levels.
Aliskiren
Contraindicated in diabetic patients due to increased risk of renal impairment, hyperkalemia, and hypotension.
Diuretics
Increased risk of hypotension, especially with initial doses.
Potassium-sparing diuretics/Potassium supplements
Increased risk of hyperkalemia. Monitor serum potassium.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
The most likely manifestation of overdose is hypotension. Treatment should be symptomatic and supportive, including close monitoring of vital signs and hydration. Olmesartan is not dialyzable.
Pregnancy & Lactation
Novetor is contraindicated during the second and third trimesters of pregnancy due to fetal toxicity. Discontinue as soon as pregnancy is detected. It is not recommended during lactation due to potential adverse effects on the nursing infant.
Side Effects
Contraindications
- Pregnancy (second and third trimesters)
- Biliary obstruction
- Concomitant use with aliskiren in patients with diabetes mellitus or renal impairment (GFR <60 ml/min/1.73 m²)
- Hypersensitivity to Olmesartan Medoxomil or any component of the formulation
Drug Interactions
NSAIDs
Reduced antihypertensive effect and increased risk of renal impairment, especially in elderly or dehydrated patients.
Lithium
Increased serum lithium concentrations and toxicity. Monitor lithium levels.
Aliskiren
Contraindicated in diabetic patients due to increased risk of renal impairment, hyperkalemia, and hypotension.
Diuretics
Increased risk of hypotension, especially with initial doses.
Potassium-sparing diuretics/Potassium supplements
Increased risk of hyperkalemia. Monitor serum potassium.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
The most likely manifestation of overdose is hypotension. Treatment should be symptomatic and supportive, including close monitoring of vital signs and hydration. Olmesartan is not dialyzable.
Pregnancy & Lactation
Novetor is contraindicated during the second and third trimesters of pregnancy due to fetal toxicity. Discontinue as soon as pregnancy is detected. It is not recommended during lactation due to potential adverse effects on the nursing infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Generic versions available
Clinical Trials
Pivotal clinical trials demonstrated the efficacy of Olmesartan Medoxomil in reducing blood pressure and its safety profile. Ongoing research explores its role in cardiovascular risk reduction and other indications.
Lab Monitoring
- Blood pressure
- Serum creatinine and BUN
- Serum potassium
- Liver function tests
Doctor Notes
- Always assess renal function before initiating therapy and periodically thereafter.
- Counsel patients on the importance of adherence and lifestyle modifications.
- Avoid use in pregnant women; switch to alternative antihypertensive if pregnancy occurs.
- Monitor for signs of angioedema.
Patient Guidelines
- Take Novetor as prescribed, usually once daily.
- Do not stop taking the medicine without consulting your doctor.
- Monitor your blood pressure regularly.
- Inform your doctor about all other medications you are taking.
- Avoid potassium supplements or salt substitutes containing potassium without consulting your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your usual dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Novetor may cause dizziness, especially at the start of treatment or when changing doses. Patients should be cautioned about operating machinery or driving until they know how the medication affects them.
Lifestyle Advice
- Maintain a healthy diet low in sodium and saturated fats.
- Engage in regular physical activity as advised by your doctor.
- Avoid smoking and limit alcohol consumption.
- Manage stress effectively.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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