Novin
Generic Name
Xylometazoline Hydrochloride Nasal Drop
Manufacturer
Novin Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| novin 005 nasal drop | ৳ 6.91 | N/A |
Description
Overview of the medicine
Novin-005 Nasal Drop is a topical decongestant containing Xylometazoline Hydrochloride, used for the symptomatic relief of nasal congestion caused by colds, allergies, and sinusitis.
Uses & Indications
Dosage
Adults
Not typically recommended for adults; adult formulations usually contain 0.1% Xylometazoline. If used, 1-2 drops into each nostril, 2-3 times daily, not exceeding 3 days.
Elderly
Use with caution and under medical supervision. Dosage may need adjustment due to potential cardiovascular effects.
Renal_impairment
No specific dosage adjustment usually required for renal impairment with topical use due to minimal systemic absorption. Consult a physician.
How to Take
For nasal use only. Blow nose gently before use. Tilt head back and apply recommended drops into each nostril. Keep head tilted for a few seconds. Do not exceed recommended dose or duration.
Mechanism of Action
Xylometazoline is an alpha-adrenergic agonist that constricts the blood vessels in the nasal mucosa, thereby reducing swelling and congestion.
Pharmacokinetics
Onset
Within 5-10 minutes.
Excretion
Primarily eliminated locally or via mucociliary clearance.
Half life
Approximately 5-6 hours locally, systemic half-life negligible due to minimal absorption.
Absorption
Minimal systemic absorption after topical nasal administration.
Metabolism
Not extensively metabolized systemically due to poor absorption.
Side Effects
Contraindications
- •Hypersensitivity to xylometazoline or any component
- •Narrow-angle glaucoma
- •Rhinitis sicca or atrophic rhinitis
- •After trans-sphenoidal hypophysectomy or other transnasal/transoral surgery where dura mater has been exposed
- •Children under 2 years (for 0.05% strength); children under 12 years (for 0.1% strength)
Drug Interactions
Beta-blockers
May reduce the hypotensive effect of beta-blockers and cause hypertension.
Tricyclic Antidepressants (TCAs)
Potentiation of cardiovascular effects.
Monoamine Oxidase Inhibitors (MAOIs)
Increased risk of hypertensive crisis.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms may include severe dizziness, sweating, headache, slowed pulse, hypertension, and in children, profound CNS depression. Treatment is symptomatic and supportive, including activated charcoal if ingested.
Pregnancy & Lactation
Use during pregnancy and lactation only if clearly necessary and under medical advice. Limited data available. Systemic absorption is minimal but caution is advised.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months unopened. Discard 28 days after opening.
Availability
Pharmacies, drugstores
Approval Status
Approved by regulatory authorities
Patent Status
Generic available, original patent expired
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