Novonil
Generic Name
Norethisterone
Manufacturer
General Pharmaceutical Company
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| novonil 10 mg tablet | ৳ 7.00 | ৳ 105.00 |
Description
Overview of the medicine
Novonil 10 mg Tablet contains Norethisterone, a synthetic progestin hormone. It is primarily used for managing various menstrual disorders, endometriosis, and as a component in hormone replacement therapy. It can also be used to delay periods.
Uses & Indications
Dosage
Adults
Dosage varies greatly depending on the indication. For dysfunctional uterine bleeding: 5-10 mg daily for 10 days. For delaying periods: 5 mg three times daily starting 3 days before expected period. For endometriosis: 10 mg daily for 6-9 months.
Elderly
Caution is advised; lower doses may be necessary. Use under medical supervision.
Renal_impairment
No specific dose adjustment guidelines; use with caution.
How to Take
Take orally with water. Can be taken with or without food. Follow the physician's instructions regarding dose and duration strictly.
Mechanism of Action
Norethisterone acts similarly to natural progesterone, primarily by transforming the proliferative endometrium into a secretory endometrium. It suppresses ovulation, thickens cervical mucus, and thins the endometrial lining, depending on the dosage and indication.
Pharmacokinetics
Onset
Effects on endometrium typically begin within hours to days.
Excretion
Mainly via urine (50-70%) and feces (30-40%) as metabolites.
Half life
Approximately 5-13 hours.
Absorption
Well absorbed orally, with peak plasma concentrations occurring within 1-2 hours.
Metabolism
Extensively metabolized in the liver, primarily by reduction and hydroxylation, followed by sulfation and glucuronidation.
Side Effects
Contraindications
- Known or suspected pregnancy
- Undiagnosed vaginal bleeding
- Severe liver disease or tumors
- History of thrombophlebitis or thromboembolic disorders
- Hypersensitivity to Norethisterone or any components
Drug Interactions
Warfarin
May alter anticoagulant effect; monitor INR.
Ciclosporin
May increase plasma levels of ciclosporin.
Rifampicin, Carbamazepine, Phenytoin
May reduce the effectiveness of Norethisterone by increasing its metabolism.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, breast tenderness, and vaginal bleeding. Treatment is symptomatic and supportive. No specific antidote.
Pregnancy & Lactation
Contraindicated during pregnancy. Avoid use during lactation as it can pass into breast milk and may affect breastfed infants and milk production.
Side Effects
Contraindications
- Known or suspected pregnancy
- Undiagnosed vaginal bleeding
- Severe liver disease or tumors
- History of thrombophlebitis or thromboembolic disorders
- Hypersensitivity to Norethisterone or any components
Drug Interactions
Warfarin
May alter anticoagulant effect; monitor INR.
Ciclosporin
May increase plasma levels of ciclosporin.
Rifampicin, Carbamazepine, Phenytoin
May reduce the effectiveness of Norethisterone by increasing its metabolism.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, breast tenderness, and vaginal bleeding. Treatment is symptomatic and supportive. No specific antidote.
Pregnancy & Lactation
Contraindicated during pregnancy. Avoid use during lactation as it can pass into breast milk and may affect breastfed infants and milk production.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Norethisterone has been extensively studied in numerous clinical trials for its various indications, supporting its efficacy and safety profile over decades of use.
Lab Monitoring
- Periodic physical examination including breast and pelvic examination
- Blood pressure monitoring
- Liver function tests (if signs of hepatic dysfunction)
- Coagulation parameters (if history of thromboembolic events)
Doctor Notes
- Advise patients on potential for irregular bleeding, especially during initial cycles.
- Educate patients about non-contraceptive use of this drug.
- Consider patient's cardiovascular risk factors before prescribing, especially for long-term use.
Patient Guidelines
- Take medicine exactly as prescribed.
- Report any unusual bleeding or severe side effects immediately.
- Do not stop taking the medicine without consulting your doctor.
- This medicine does not protect against sexually transmitted infections.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not double the dose.
Driving Precautions
Norethisterone generally does not affect the ability to drive or operate machinery. However, if you experience dizziness or visual disturbances, avoid such activities.
Lifestyle Advice
- Maintain a healthy diet and regular exercise.
- Avoid smoking, especially if using for hormone replacement therapy.
- Discuss any pre-existing conditions or concurrent medications with your doctor.
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Global Brand Names
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