Novonil
Generic Name
Olanzapine
Manufacturer
General Pharmaceuticals Ltd. (example)
Country
Bangladesh (example)
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| novonil 20 mg tablet | ৳ 10.00 | ৳ 150.00 |
Description
Overview of the medicine
Novonil 20 mg Tablet contains Olanzapine, an atypical antipsychotic medication used to treat schizophrenia and bipolar disorder. It helps to restore the balance of certain natural substances in the brain.
Uses & Indications
Dosage
Adults
Schizophrenia: Initially 5-10 mg once daily, adjusted to 10-20 mg/day. Bipolar mania: Initially 10-15 mg once daily, adjusted to 5-20 mg/day. Prevention of recurrence in bipolar disorder: 10 mg/day.
Elderly
Lower starting dose (e.g., 5 mg/day) and slower titration may be considered, especially for those with factors that could result in slower metabolism.
Renal_impairment
No specific dose adjustment is routinely required, but caution is advised in severe cases.
How to Take
Take orally, once daily, with or without food. The tablet should be swallowed whole with water. It is advisable to take it at the same time each day.
Mechanism of Action
Olanzapine acts as an antagonist at multiple receptor sites, including dopamine D1, D2, D3, D4, and D5 receptors, serotonin 5-HT2A, 5-HT2C, 5-HT3, and 5-HT6 receptors, alpha1-adrenergic receptors, and histamine H1 receptors. Its efficacy in schizophrenia and bipolar disorder is thought to be mediated through a combination of dopamine and serotonin antagonism.
Pharmacokinetics
Onset
Antipsychotic effects may take several days to weeks to become fully apparent. Sedation can occur within hours.
Excretion
Mainly excreted in urine (approximately 57%) and feces (approximately 30%). Less than 7% is excreted as unchanged drug.
Half life
Approximately 21-54 hours (mean 33 hours) in healthy subjects. It may be prolonged in elderly or those with hepatic impairment.
Absorption
Readily absorbed after oral administration, reaching peak plasma concentrations in 5-8 hours. Food does not affect the rate or extent of absorption.
Metabolism
Extensively metabolized in the liver, primarily by glucuronidation and cytochrome P450 enzymes (CYP1A2 and CYP2D6). N-demethylation and 10-hydroxylation are the major metabolic pathways.
Side Effects
Contraindications
- Hypersensitivity to Olanzapine or any component of the formulation
- Patients with known narrow-angle glaucoma
Drug Interactions
Fluvoxamine
May inhibit olanzapine metabolism, increasing plasma levels.
Carbamazepine
May increase olanzapine clearance, reducing plasma levels.
Antihypertensives
Potentiation of orthostatic hypotension.
Alcohol/CNS Depressants
Increased CNS depressant effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include drowsiness, slurred speech, tachycardia, extrapyramidal symptoms, and respiratory depression. Management is supportive, including maintaining airway, oxygenation, and hydration.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Not recommended during breastfeeding as it is excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to Olanzapine or any component of the formulation
- Patients with known narrow-angle glaucoma
Drug Interactions
Fluvoxamine
May inhibit olanzapine metabolism, increasing plasma levels.
Carbamazepine
May increase olanzapine clearance, reducing plasma levels.
Antihypertensives
Potentiation of orthostatic hypotension.
Alcohol/CNS Depressants
Increased CNS depressant effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include drowsiness, slurred speech, tachycardia, extrapyramidal symptoms, and respiratory depression. Management is supportive, including maintaining airway, oxygenation, and hydration.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Not recommended during breastfeeding as it is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture, specific to lot.
Availability
Available in pharmacies worldwide
Approval Status
FDA approved (for Olanzapine)
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established olanzapine's efficacy and safety for schizophrenia and bipolar disorder. Ongoing research includes long-term safety profiles and comparative effectiveness studies.
Lab Monitoring
- Fasting blood glucose
- Lipid panel
- Weight and BMI
- Liver function tests (LFTs)
Doctor Notes
- Monitor patient for metabolic syndrome components (weight, glucose, lipids) regularly.
- Educate patients on the importance of adherence and potential side effects.
- Assess for tardive dyskinesia periodically.
Patient Guidelines
- Take medicine regularly as prescribed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Report any unusual side effects, especially uncontrollable movements or fever.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause drowsiness and dizziness. Patients should be cautious when driving or operating machinery until they know how Novonil affects them.
Lifestyle Advice
- Maintain a healthy diet to manage weight gain.
- Engage in regular physical activity.
- Avoid alcohol while on this medication.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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