Odofex
Generic Name
Fexofenadine
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| odofex 120 mg tablet | ৳ 8.00 | N/A |
Description
Overview of the medicine
Odofex (Fexofenadine) is a non-drowsy antihistamine used to relieve allergy symptoms such as sneezing, runny nose, itchy watery eyes, and itchy nose or throat. It is also used to treat chronic idiopathic urticaria (hives).
Uses & Indications
Dosage
Adults
For seasonal allergic rhinitis, 60 mg twice daily or 120 mg or 180 mg once daily. For chronic idiopathic urticaria, 60 mg twice daily or 180 mg once daily.
Elderly
No specific dose adjustment generally required, but caution with renal impairment.
Renal_impairment
For severe renal impairment, initial dose of 60 mg once daily is recommended.
How to Take
Taken orally with water, preferably before a meal. Do not take with fruit juice.
Mechanism of Action
Fexofenadine is a selective peripheral H1-blocker. It inhibits histamine release from mast cells and reduces the effects of histamine on H1 receptors, thereby alleviating allergy symptoms.
Pharmacokinetics
Onset
Onset of action within 1 hour.
Excretion
Primarily excreted unchanged in the feces (80%) and urine (11%).
Half life
Approximately 11-15 hours.
Absorption
Rapidly absorbed after oral administration; peak plasma concentrations reached in 2-3 hours.
Metabolism
Minimally metabolized (less than 5%) in the liver.
Side Effects
Contraindications
- Hypersensitivity to fexofenadine or any component of the formulation
Drug Interactions
Erythromycin and Ketoconazole
May increase fexofenadine plasma concentrations. Clinical significance usually minimal.
Antacids containing aluminum or magnesium
May decrease fexofenadine absorption. Separate administration by at least 2 hours.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose symptoms may include dizziness, drowsiness, and dry mouth. Management is supportive and symptomatic; hemodialysis is ineffective.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and the potential benefits outweigh the potential risks. Excreted in breast milk, so caution is advised in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to fexofenadine or any component of the formulation
Drug Interactions
Erythromycin and Ketoconazole
May increase fexofenadine plasma concentrations. Clinical significance usually minimal.
Antacids containing aluminum or magnesium
May decrease fexofenadine absorption. Separate administration by at least 2 hours.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose symptoms may include dizziness, drowsiness, and dry mouth. Management is supportive and symptomatic; hemodialysis is ineffective.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and the potential benefits outweigh the potential risks. Excreted in breast milk, so caution is advised in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from manufacturing date, check specific packaging.
Availability
Available in pharmacies nationwide
Approval Status
FDA/DGDA approved
Patent Status
Generic available (patent expired)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated efficacy and safety in treating seasonal allergic rhinitis and chronic idiopathic urticaria.
Lab Monitoring
- No specific lab monitoring required for fexofenadine use.
Doctor Notes
- Advise patients about potential for minimal sedation.
- Emphasize avoiding fruit juices.
- Consider renal dose adjustment for severe impairment.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid taking with fruit juices.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
Take the missed dose as soon as you remember, unless it is almost time for your next dose. Do not double the dose.
Driving Precautions
Fexofenadine is generally non-drowsy, but individual responses vary. Exercise caution until you know how it affects you.
Lifestyle Advice
- Avoid known allergens to reduce symptoms.
- Maintain good hydration.
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Global Brand Names
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