Ofpain
Generic Name
Ketorolac Tromethamine
Manufacturer
MediCorp Pharma
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ofpain 10 mg tablet | ৳ 10.03 | N/A |
Description
Overview of the medicine
Ofpain 10 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) used for the short-term management of moderate to severe acute pain. It works by blocking certain natural substances in the body that cause inflammation and pain.
Uses & Indications
Dosage
Adults
Initially 10 mg orally, then 10-20 mg every 4-6 hours as needed. Maximum 40 mg/day for not more than 5 days.
Elderly
Lower doses (e.g., 10 mg every 6-8 hours) may be required due to decreased renal function and increased risk of adverse effects.
Renal_impairment
Dose adjustment necessary; contra-indicated in severe renal impairment.
How to Take
Take with food or milk to minimize gastrointestinal upset. Do not chew or crush the tablet. Swallow whole with water.
Mechanism of Action
Ketorolac inhibits prostaglandin synthesis by reversibly blocking the cyclooxygenase (COX-1 and COX-2) enzymes. This results in reduced formation of prostaglandin precursors, which are involved in inflammation, pain, and fever.
Pharmacokinetics
Onset
30-60 minutes (oral)
Excretion
Mainly excreted in urine (91%) and feces (6%).
Half life
Approximately 5-6 hours
Absorption
Rapidly and completely absorbed after oral administration. Peak plasma concentrations are achieved in about 30-60 minutes.
Metabolism
Extensively metabolized in the liver, primarily by glucuronidation.
Side Effects
Contraindications
- Hypersensitivity to ketorolac or other NSAIDs
- Active peptic ulcer, GI bleeding
- Severe renal impairment
- Advanced heart failure
- Prior to major surgery
- Pregnancy (third trimester)
- History of asthma, urticaria, or allergic-type reactions after aspirin or other NSAIDs
Drug Interactions
Lithium
Increased lithium plasma levels.
Methotrexate
Increased methotrexate toxicity.
Warfarin, Heparin
Increased risk of bleeding.
Diuretics (Furosemide)
Reduced diuretic and antihypertensive effects.
ACE inhibitors, Angiotensin II receptor blockers
Increased risk of renal impairment.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, nausea, vomiting, epigastric pain, GI bleeding, and rarely, acute renal failure, hypertension, and respiratory depression. Treatment is symptomatic and supportive; no specific antidote.
Pregnancy & Lactation
Not recommended during the third trimester of pregnancy due to risk of premature closure of fetal ductus arteriosus. Use during lactation is generally discouraged as NSAIDs are excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to ketorolac or other NSAIDs
- Active peptic ulcer, GI bleeding
- Severe renal impairment
- Advanced heart failure
- Prior to major surgery
- Pregnancy (third trimester)
- History of asthma, urticaria, or allergic-type reactions after aspirin or other NSAIDs
Drug Interactions
Lithium
Increased lithium plasma levels.
Methotrexate
Increased methotrexate toxicity.
Warfarin, Heparin
Increased risk of bleeding.
Diuretics (Furosemide)
Reduced diuretic and antihypertensive effects.
ACE inhibitors, Angiotensin II receptor blockers
Increased risk of renal impairment.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, nausea, vomiting, epigastric pain, GI bleeding, and rarely, acute renal failure, hypertension, and respiratory depression. Treatment is symptomatic and supportive; no specific antidote.
Pregnancy & Lactation
Not recommended during the third trimester of pregnancy due to risk of premature closure of fetal ductus arteriosus. Use during lactation is generally discouraged as NSAIDs are excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by health authorities
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have demonstrated the efficacy of ketorolac in managing acute moderate to severe pain, often comparing it to opioids for short-term use.
Lab Monitoring
- Monitor complete blood count (CBC) during long-term therapy
- Renal function (creatinine, BUN) for patients at risk
- Liver function tests (ALT, AST) periodically
Doctor Notes
- Emphasize short-term use only (max 5 days) for acute pain.
- Assess cardiovascular and gastrointestinal risk factors before prescribing.
- Monitor renal function, especially in elderly or compromised patients.
Patient Guidelines
- Take as directed by your doctor. Do not exceed the prescribed dose or duration of use.
- Inform your doctor about all other medications you are taking.
- Report any signs of unusual bleeding, dark stools, or severe stomach pain immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it's close to your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
This medicine may cause dizziness or drowsiness. Avoid driving or operating heavy machinery until you know how it affects you.
Lifestyle Advice
- Avoid alcohol consumption while taking this medication.
- Maintain adequate hydration.
- Discuss any pre-existing conditions (e.g., heart disease, kidney disease) with your doctor.
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Global Brand Names
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