Ofpain
Generic Name
Ketorolac Tromethamine Injection
Manufacturer
Acme Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ofpain 30 mg injection | ৳ 55.16 | N/A |
Description
Overview of the medicine
Ofpain 30 mg Injection contains Ketorolac Tromethamine, a non-steroidal anti-inflammatory drug (NSAID) used for the short-term management of moderate to severe acute pain. It is typically administered via intramuscular (IM) or intravenous (IV) injection.
Uses & Indications
Dosage
Adults
Initial dose 30 mg IM or IV, followed by 10-30 mg every 4-6 hours as needed. Maximum daily dose 90 mg for adults under 65 kg and 60 mg for adults over 65 kg.
Elderly
For patients 65 years and older, a lower dose is recommended (e.g., 15 mg IM or IV every 4-6 hours), with a maximum daily dose of 60 mg.
Renal_impairment
Dosage adjustment is necessary. Severe renal impairment is a contraindication. For mild to moderate impairment, lower doses (e.g., 15 mg every 4-6 hours) and reduced maximum daily dose (e.g., 60 mg) are recommended.
How to Take
Ofpain 30 mg Injection should be administered by a healthcare professional, either intramuscularly (IM) as a deep injection into a large muscle or intravenously (IV) as a bolus over at least 15 seconds.
Mechanism of Action
Ketorolac inhibits prostaglandin synthesis by non-selectively blocking cyclooxygenase (COX-1 and COX-2) enzymes. This action reduces inflammation, pain, and fever.
Pharmacokinetics
Onset
Analgesia typically begins within 10 minutes following IV administration and 30-60 minutes following IM administration.
Excretion
Mainly excreted by the kidneys (approximately 90%), with a small amount excreted in feces.
Half life
Approximately 4-6 hours.
Absorption
Rapidly and completely absorbed after IM administration. Peak plasma concentrations are achieved within 30-60 minutes.
Metabolism
Extensively metabolized in the liver, primarily via glucuronidation.
Side Effects
Contraindications
- Hypersensitivity to ketorolac, aspirin, or other NSAIDs
- Active peptic ulcer, recent gastrointestinal bleeding or perforation
- Moderate to severe renal impairment or risk of renal failure
- Advanced heart failure
- Patients with cerebrovascular bleeding or other bleeding disorders
- As prophylactic analgesic before major surgery
- In combination with other NSAIDs or aspirin
Drug Interactions
Lithium
Increased plasma lithium levels and potential toxicity.
Diuretics
May reduce the natriuretic effect of loop and thiazide diuretics.
Methotrexate
Increased plasma levels and toxicity of methotrexate.
Other NSAIDs or Aspirin
Increased risk of gastrointestinal adverse effects.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
ACE Inhibitors / Angiotensin II Receptor Blockers (ARBs)
May reduce the antihypertensive effect and increase the risk of renal impairment.
Storage
Store below 30°C. Protect from light. Do not freeze.
Overdose
Symptoms of overdose may include abdominal pain, nausea, vomiting, lethargy, and drowsiness. Rare cases of gastrointestinal bleeding, acute renal failure, hypertension, and respiratory depression have occurred. Management is symptomatic and supportive. Gastric emptying and activated charcoal may be considered if ingestion was recent. Hemodialysis is not effective for removing ketorolac.
Pregnancy & Lactation
Pregnancy Category C (first and second trimesters), Category D (third trimester and near delivery). Not recommended during pregnancy, especially in the third trimester due to potential premature closure of the fetal ductus arteriosus. Use during lactation is generally discouraged as ketorolac is excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to ketorolac, aspirin, or other NSAIDs
- Active peptic ulcer, recent gastrointestinal bleeding or perforation
- Moderate to severe renal impairment or risk of renal failure
- Advanced heart failure
- Patients with cerebrovascular bleeding or other bleeding disorders
- As prophylactic analgesic before major surgery
- In combination with other NSAIDs or aspirin
Drug Interactions
Lithium
Increased plasma lithium levels and potential toxicity.
Diuretics
May reduce the natriuretic effect of loop and thiazide diuretics.
Methotrexate
Increased plasma levels and toxicity of methotrexate.
Other NSAIDs or Aspirin
Increased risk of gastrointestinal adverse effects.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
ACE Inhibitors / Angiotensin II Receptor Blockers (ARBs)
May reduce the antihypertensive effect and increase the risk of renal impairment.
Storage
Store below 30°C. Protect from light. Do not freeze.
Overdose
Symptoms of overdose may include abdominal pain, nausea, vomiting, lethargy, and drowsiness. Rare cases of gastrointestinal bleeding, acute renal failure, hypertension, and respiratory depression have occurred. Management is symptomatic and supportive. Gastric emptying and activated charcoal may be considered if ingestion was recent. Hemodialysis is not effective for removing ketorolac.
Pregnancy & Lactation
Pregnancy Category C (first and second trimesters), Category D (third trimester and near delivery). Not recommended during pregnancy, especially in the third trimester due to potential premature closure of the fetal ductus arteriosus. Use during lactation is generally discouraged as ketorolac is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture, when stored as recommended.
Availability
Pharmacies, Hospitals, Clinics
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Ketorolac has undergone extensive clinical trials demonstrating its efficacy and safety for short-term pain management. Further trials continue to explore its role in various acute pain settings.
Lab Monitoring
- Renal function tests (BUN, creatinine) before and during treatment
- Liver function tests (ALT, AST) periodically
- Complete Blood Count (CBC) if used for more than 5 days or in patients with bleeding risk
Doctor Notes
- Emphasize the short-term use (max 5 days) for acute pain.
- Monitor renal function, especially in elderly and patients with pre-existing renal impairment.
- Caution with concomitant use of anticoagulants, other NSAIDs, and selective serotonin reuptake inhibitors (SSRIs) due to increased bleeding risk.
- Assess for history of GI disease, cardiovascular risk factors, and asthma before initiation.
Patient Guidelines
- This medicine will be administered by a healthcare professional.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
- Report any unusual bleeding, persistent stomach pain, or allergic reactions immediately.
- Do not exceed the prescribed duration of treatment, which is typically not more than 5 days.
Missed Dose Advice
As this medicine is administered by a healthcare professional, a missed dose is unlikely. If you believe a dose was missed, contact your doctor or nurse immediately.
Driving Precautions
This medicine may cause dizziness or drowsiness. Avoid driving or operating heavy machinery if you experience these effects.
Lifestyle Advice
- Avoid alcohol consumption during treatment as it may increase the risk of stomach bleeding.
- Maintain adequate hydration.
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