Ofran
Generic Name
Ondansetron 8 mg Injection
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ofran 8 mg injection | ৳ 32.00 | N/A |
Description
Overview of the medicine
Ofran 8 mg Injection contains Ondansetron, which is used to prevent and treat nausea and vomiting caused by chemotherapy, radiation therapy, and surgery.
Uses & Indications
Dosage
Adults
Chemotherapy-induced nausea and vomiting (CINV): 8 mg IV infused over 15 minutes, starting 30 minutes before chemotherapy. Post-operative nausea and vomiting (PONV): 4 mg IV/IM as a single dose at induction of anesthesia.
Elderly
No specific dose adjustment is generally required, but caution is advised in very elderly patients (over 75 years) due to increased half-life and potential for QT prolongation.
Renal_impairment
No dose adjustment is required for patients with renal impairment.
How to Take
Administer intravenously (IV) slowly over 2-5 minutes or intramuscularly (IM). For prevention of CINV, it can be given as an infusion over 15 minutes.
Mechanism of Action
Ondansetron selectively blocks serotonin 5-HT3 receptors located both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone, thereby preventing nausea and vomiting.
Pharmacokinetics
Onset
Within 30 minutes after intravenous administration.
Excretion
Approximately 5% excreted unchanged in urine, remaining as metabolites via renal and fecal routes.
Half life
Approximately 3-6 hours in adults.
Absorption
Rapid and complete absorption after oral administration, but for injection, it bypasses absorption and is immediately available.
Metabolism
Extensively metabolized in the liver, primarily by hydroxylation followed by glucuronide or sulfate conjugation.
Side Effects
Contraindications
- Known hypersensitivity to Ondansetron or any component of the formulation.
- Concomitant use with apomorphine (due to risk of profound hypotension and loss of consciousness).
Drug Interactions
Tramadol
May reduce the analgesic effect of tramadol.
Apomorphine
Concomitant use is contraindicated due to severe hypotension and loss of consciousness.
Drugs prolonging QT interval
Use with caution with other drugs known to prolong the QT interval (e.g., amiodarone, erythromycin, sotalol) as Ondansetron itself can prolong QT interval.
Phenytoin, Carbamazepine, Rifampicin
May increase the clearance of Ondansetron, reducing its plasma levels and potentially efficacy.
Storage
Store below 30°C, protected from light. Do not freeze.
Overdose
Symptoms of overdose include transient visual disturbances, constipation, severe hypotension, and a vagal episode with transient AV block. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Ondansetron should be used during pregnancy only if clearly needed. Excreted in breast milk, so caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Known hypersensitivity to Ondansetron or any component of the formulation.
- Concomitant use with apomorphine (due to risk of profound hypotension and loss of consciousness).
Drug Interactions
Tramadol
May reduce the analgesic effect of tramadol.
Apomorphine
Concomitant use is contraindicated due to severe hypotension and loss of consciousness.
Drugs prolonging QT interval
Use with caution with other drugs known to prolong the QT interval (e.g., amiodarone, erythromycin, sotalol) as Ondansetron itself can prolong QT interval.
Phenytoin, Carbamazepine, Rifampicin
May increase the clearance of Ondansetron, reducing its plasma levels and potentially efficacy.
Storage
Store below 30°C, protected from light. Do not freeze.
Overdose
Symptoms of overdose include transient visual disturbances, constipation, severe hypotension, and a vagal episode with transient AV block. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Ondansetron should be used during pregnancy only if clearly needed. Excreted in breast milk, so caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, refer to packaging for exact date.
Availability
Hospitals, pharmacies
Approval Status
Approved globally
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Ondansetron has been extensively studied in numerous clinical trials demonstrating its efficacy and safety for preventing chemotherapy-induced, radiotherapy-induced, and post-operative nausea and vomiting.
Lab Monitoring
- Monitor ECG for QT prolongation, especially in patients with pre-existing cardiac conditions, electrolyte abnormalities (hypokalemia, hypomagnesemia), or those taking other QT-prolonging drugs.
Doctor Notes
- Ensure proper hydration, especially in patients undergoing chemotherapy.
- Monitor ECG in patients with risk factors for QT prolongation.
- Avoid concomitant use with apomorphine.
Patient Guidelines
- Report any unusual side effects or worsening of symptoms to your doctor immediately.
- Do not drive or operate heavy machinery if you experience dizziness or drowsiness.
- Follow your doctor's instructions regarding the administration and dosage.
Missed Dose Advice
Since this is an injection administered by a healthcare professional, a missed dose is unlikely. If a dose is somehow missed, consult your doctor immediately.
Driving Precautions
Ondansetron may cause dizziness or drowsiness in some patients. Patients should be advised not to drive or operate machinery if affected.
Lifestyle Advice
- Stay hydrated by drinking plenty of fluids.
- Maintain a balanced diet as tolerated to support recovery.
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