Olmesta
Generic Name
Olmesartan Medoxomil
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| olmesta 10 mg tablet | ৳ 6.00 | ৳ 60.00 |
| olmesta 20 mg tablet | ৳ 10.00 | ৳ 100.00 |
| olmesta 40 mg tablet | ৳ 18.00 | ৳ 180.00 |
Description
Overview of the medicine
Olmesta contains Olmesartan Medoxomil, an angiotensin II receptor blocker (ARB) used to treat high blood pressure (hypertension). It works by relaxing blood vessels, allowing blood to flow more easily.
Uses & Indications
Dosage
Adults
Initial dose is 20 mg once daily. The dose can be increased to a maximum of 40 mg once daily if blood pressure is not adequately controlled. Doses above 40 mg do not appear to provide additional benefit.
Elderly
No initial dose adjustment is generally required for elderly patients. However, caution should be exercised in patients with renal impairment.
Renal_impairment
For patients with moderate to severe renal impairment (creatinine clearance 20-60 mL/min), the initial dose is 10 mg once daily. Not recommended for patients with severe renal impairment (creatinine clearance < 20 mL/min).
How to Take
Olmesta tablets should be swallowed whole with water, with or without food, at approximately the same time each day.
Mechanism of Action
Olmesartan Medoxomil is a prodrug that is hydrolyzed to olmesartan during absorption. Olmesartan selectively blocks the binding of angiotensin II to the AT1 receptor in vascular smooth muscle and other tissues, inhibiting the vasoconstrictor and aldosterone-secreting effects of angiotensin II. This results in vasodilation, decreased blood pressure, and reduced fluid retention.
Pharmacokinetics
Onset
Significant blood pressure reduction typically within 2 weeks; maximal effect within 4-8 weeks.
Excretion
Eliminated via renal excretion (30-50%) and hepatic/biliary excretion (50-70%).
Half life
Approximately 10-15 hours.
Absorption
Rapidly and completely hydrolyzed to olmesartan during absorption from the gastrointestinal tract. Absolute bioavailability is approximately 26%. Peak plasma concentrations are reached in 1-2 hours.
Metabolism
Olmesartan itself is not metabolized further. Olmesartan Medoxomil is a prodrug; it is hydrolyzed to its active form (olmesartan) in the gut.
Side Effects
Contraindications
- Pregnancy (especially second and third trimesters)
- Severe hepatic impairment
- Concomitant use with aliskiren in patients with diabetes or renal impairment (GFR < 60 mL/min/1.73 m²)
Drug Interactions
Lithium
Increases serum lithium concentrations and toxicity. Monitor lithium levels.
Aliskiren
Increased risk of renal impairment, hyperkalemia, and hypotension in diabetic patients.
NSAIDs (e.g., ibuprofen, naproxen)
May reduce the antihypertensive effect and increase the risk of renal impairment, especially in elderly, volume-depleted, or renally impaired patients.
Potassium-sparing diuretics/Potassium supplements
Increased risk of hyperkalemia. Monitor serum potassium levels.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypotension (low blood pressure) and possibly tachycardia (rapid heart rate) or bradycardia (slow heart rate). Treatment is symptomatic and supportive, including close monitoring of vital signs and fluid/electrolyte balance.
Pregnancy & Lactation
Olmesta is contraindicated in the second and third trimesters of pregnancy due to fetal toxicity. It is not recommended during breastfeeding.
Side Effects
Contraindications
- Pregnancy (especially second and third trimesters)
- Severe hepatic impairment
- Concomitant use with aliskiren in patients with diabetes or renal impairment (GFR < 60 mL/min/1.73 m²)
Drug Interactions
Lithium
Increases serum lithium concentrations and toxicity. Monitor lithium levels.
Aliskiren
Increased risk of renal impairment, hyperkalemia, and hypotension in diabetic patients.
NSAIDs (e.g., ibuprofen, naproxen)
May reduce the antihypertensive effect and increase the risk of renal impairment, especially in elderly, volume-depleted, or renally impaired patients.
Potassium-sparing diuretics/Potassium supplements
Increased risk of hyperkalemia. Monitor serum potassium levels.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypotension (low blood pressure) and possibly tachycardia (rapid heart rate) or bradycardia (slow heart rate). Treatment is symptomatic and supportive, including close monitoring of vital signs and fluid/electrolyte balance.
Pregnancy & Lactation
Olmesta is contraindicated in the second and third trimesters of pregnancy due to fetal toxicity. It is not recommended during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date.
Availability
Pharmacies nationwide in Bangladesh
Approval Status
Approved (e.g., DGDA, FDA)
Patent Status
Off-patent (generic versions available)
Clinical Trials
Olmesartan has undergone extensive clinical trials demonstrating its efficacy and safety in the treatment of hypertension.
Lab Monitoring
- Blood pressure monitoring
- Renal function (serum creatinine, BUN)
- Serum potassium levels
Doctor Notes
- Regularly monitor patient's blood pressure, renal function, and serum potassium levels.
- Educate patients about the importance of adherence to therapy and symptoms of angioedema.
- Caution should be exercised in patients with severe congestive heart failure or renal artery stenosis.
Patient Guidelines
- Take your medicine regularly as prescribed by your doctor.
- Do not stop taking Olmesta without consulting your doctor, even if you feel well.
- Report any unusual side effects, especially swelling of the face, lips, or tongue, immediately to your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Olmesta may cause dizziness or lightheadedness, especially when starting treatment. If you experience these symptoms, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a healthy diet low in sodium.
- Engage in regular physical activity.
- Avoid smoking and limit alcohol intake.
- Manage stress levels.
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