Olmetor
Generic Name
Olmesartan Medoxomil
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| olmetor 40 mg tablet | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Olmetor 40 mg tablet contains Olmesartan Medoxomil, an angiotensin II receptor blocker used to treat high blood pressure (hypertension) and to reduce the risk of cardiovascular events. It works by relaxing blood vessels, allowing blood to flow more easily.
Uses & Indications
Dosage
Adults
Initial dose 20 mg once daily, adjusted to maximum 40 mg once daily based on blood pressure response. Can be taken with or without food.
Elderly
No initial dosage adjustment required for elderly patients, but careful monitoring is advised.
Renal_impairment
For mild to moderate renal impairment, no dosage adjustment is usually necessary. For severe impairment (creatinine clearance <20 mL/min), a starting dose of 10 mg once daily is recommended, with a maximum of 20 mg once daily.
How to Take
Take the tablet orally once daily, with or without food, at approximately the same time each day.
Mechanism of Action
Olmesartan Medoxomil is a prodrug that is hydrolyzed to olmesartan during absorption from the gastrointestinal tract. Olmesartan selectively blocks the binding of angiotensin II to the AT1 receptor in vascular smooth muscle and other tissues. This inhibition prevents the vasoconstrictive and aldosterone-secreting effects of angiotensin II, leading to vasodilation and reduced blood pressure.
Pharmacokinetics
Onset
Within 2 weeks for full effect, initial effect within 1 week.
Excretion
Approximately 35-50% excreted via urine and the remainder via feces/bile.
Half life
Approximately 13 hours.
Absorption
Rapidly and completely absorbed from the gastrointestinal tract and rapidly converted to olmesartan. Bioavailability is approximately 26%.
Metabolism
Olmesartan is not metabolized by the cytochrome P450 system. It is extensively metabolized in the gut wall during absorption to its active form, olmesartan.
Side Effects
Contraindications
- Hypersensitivity to olmesartan medoxomil or any component of the product.
- Pregnancy (second and third trimesters).
- Concomitant use with aliskiren in patients with diabetes or renal impairment (GFR <60 mL/min/1.73 m²).
- Biliary obstruction.
Drug Interactions
Lithium
Increased serum lithium concentrations and toxicity. Monitor lithium levels.
Diuretics
Increased risk of hypotension, especially with high doses of diuretics.
ACE Inhibitors, Aliskiren
Increased risk of hypotension, hyperkalemia, and renal impairment (particularly in patients with diabetes or renal impairment). Avoid concomitant use.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce the antihypertensive effect of olmesartan. Increased risk of renal impairment, especially in elderly, volume-depleted, or those with impaired renal function.
Potassium-sparing diuretics, potassium supplements, salt substitutes containing potassium
Increased risk of hyperkalemia. Monitor serum potassium levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypotension and tachycardia; bradycardia may occur. Treatment is supportive and symptomatic. If ingestion is recent, gastric lavage may be considered. Administer intravenous fluids to support blood pressure. Olmesartan is not removed by hemodialysis.
Pregnancy & Lactation
Category D in pregnancy (second and third trimesters) due to risk of fetal harm. Not recommended during breastfeeding as it is unknown if olmesartan is excreted in human milk. Discuss risks and benefits with a healthcare provider.
Side Effects
Contraindications
- Hypersensitivity to olmesartan medoxomil or any component of the product.
- Pregnancy (second and third trimesters).
- Concomitant use with aliskiren in patients with diabetes or renal impairment (GFR <60 mL/min/1.73 m²).
- Biliary obstruction.
Drug Interactions
Lithium
Increased serum lithium concentrations and toxicity. Monitor lithium levels.
Diuretics
Increased risk of hypotension, especially with high doses of diuretics.
ACE Inhibitors, Aliskiren
Increased risk of hypotension, hyperkalemia, and renal impairment (particularly in patients with diabetes or renal impairment). Avoid concomitant use.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce the antihypertensive effect of olmesartan. Increased risk of renal impairment, especially in elderly, volume-depleted, or those with impaired renal function.
Potassium-sparing diuretics, potassium supplements, salt substitutes containing potassium
Increased risk of hyperkalemia. Monitor serum potassium levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypotension and tachycardia; bradycardia may occur. Treatment is supportive and symptomatic. If ingestion is recent, gastric lavage may be considered. Administer intravenous fluids to support blood pressure. Olmesartan is not removed by hemodialysis.
Pregnancy & Lactation
Category D in pregnancy (second and third trimesters) due to risk of fetal harm. Not recommended during breastfeeding as it is unknown if olmesartan is excreted in human milk. Discuss risks and benefits with a healthcare provider.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies, hospitals
Approval Status
Approved by FDA and local regulatory authorities (e.g., DGDA)
Patent Status
Generic available (patent expired for original drug)
Clinical Trials
Numerous clinical trials have demonstrated the efficacy and safety of Olmesartan in reducing blood pressure and cardiovascular risk, including the ROADMAP and ALTITUDE trials (though ALTITUDE showed no benefit with aliskiren in high-risk patients when added to an ARB).
Lab Monitoring
- Blood pressure monitoring
- Renal function (serum creatinine, BUN)
- Serum potassium levels
- Liver function tests (periodically)
Doctor Notes
- Advise patients to monitor blood pressure regularly at home.
- Emphasize adherence to lifestyle modifications alongside medication.
- Caution against abrupt discontinuation due to risk of rebound hypertension.
- Check renal function and potassium levels periodically, especially in patients with pre-existing renal impairment or those on diuretics.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor, even if you feel better.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
- Avoid potassium-rich salt substitutes unless advised by your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness or lightheadedness, especially at the start of treatment or when the dose is increased. Avoid driving or operating machinery until you know how Olmetor affects you.
Lifestyle Advice
- Maintain a healthy diet low in sodium.
- Engage in regular physical activity.
- Limit alcohol intake.
- Quit smoking.
- Manage stress effectively.
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